10,305 research outputs found
TetraÂaquaÂbisÂ[4-(pyrazin-2-ylsulfanylmethÂyl)benzoato]manganese(II) dihydrate
The title compound, [Mn(C12H9N2O2S)2(H2O)4]·2H2O, has been synthesized with a flexible asymmetrical bridging ligand, 4-(pyrazin-2-ylsulfanylmethÂyl)benzoic acid (Hpztmb). The MnII ion exhibits a centrosymmetric octaÂhedral geometry involving two carboxylÂate O atoms of two different pztmb ligands and four O atoms of four coordinated water molÂecules. The packing shows a three-dimensional supraÂmolecular network via O—H⋯O and O—H⋯N hydrogen bonds and π–π stacking interÂactions [centroid–centroid distances = 3.884 (8) and 4.034 (8) Å] between the benzene ring of one pztmb anion and the pyrazine ring of an adjacent anion
TetraÂaquaÂbisÂ[4-(pyrazin-2-ylsulfanylmethyl-κN 4)benzoato]cobalt(II)
In the title compound, [Co(C12H9N2O2S)2(H2O)4], the CoII ion, lying on an inversion center, has an octaÂhedral coordination involving two N atoms of two 4-(pyrazin-2-ylsulfÂanylmethÂyl)benzoate ligands and four water molÂecules. In the crystal, O—H⋯O hydrogen bonds between the coordinated water molÂecules and uncoordinated carboxylÂate O atoms, and weak π–π interÂactions [centroid–centroid distance = 4.105 (2) Å] between the benzene and pyrazine rings lead to a three-dimensional supraÂmolecular network
Improving R&D Project Collaboration: A Concurrent Knowledge Learning Model
The collaboration issues on research and development (R&D) projects are getting critical. Shorten time-to-market (TTM) of new product is crucial competency of high-tech industries. However, lacks of post-project review, real-time communication and information sharing make barriers to reduce TTM. This would lead to downcast competition in the globalization. In this research, a concurrent knowledge learning (CKL) model is proposed to enhance R&D project collaboration. With the CKL model, R&D collaboration could be improved via the concurrent knowledge reusability and the collaboration mechanism among partners
Comparison of the protein acetylome of endothelial cells upon shear flow and resveratrol treatment
Background: Posttranslational acetylation/deacetylation known as the acetylome is important in regulating protein activity. Shear flow (SF) and resveratrol (RSV) are two stimuli that represent physical and chemical signal separately. The acetylome co-regulated by these two stimuli remain unclear. Methods: Human umbilical cord vein endothelial cells (HUVECs) were subjected to either SF of 12 dynes/cm2 or 10 μM RSV. The purified acetylated peptides were labeled by isobaric tags for relative and absolute quantitation (iTRAQ) analysis. The signaling cascades of the identified acetylome were predicted by ingenuity pathway analysis (IPA). Co-immunoprecipitation was applied to confirm the acetylation status of proteins. Results: Five groups of proteins showed an increased acetylation upon SF and RSV treatment. After algorithm, 628 proteins with increased acetylation and 22 proteins with decreased acetylation were identified in the SF acetylome. For the acetylome regulated by RSV, 145 proteins with increased acetylation and 23 proteins with decreased acetylation were identified. Compared these two acetylomes, 129 proteins with increased acetylation and 2 proteins with decreased acetylation were co-regulated by both SF and RSV treatments. IPA analysis showed that this co-regulated acetylome was involved in heat shock response, and the signals of eNOS, STAT3, JAK/STAT and ERK/MAPK. Co-immunoprecipitation analysis further confirmed the acetylated status of mitochondrial HSP60 and mitochondrial citrate synthase. Conclusions: This study indicated that physical signal is more complicated than chemical signal in the case of acetylome. The co-regulated proteins are worthy for further study in discussing synergetic effect between physical and chemical signal in cardioprotection
Hexyl (E)-3-(3,4-dihyÂdroxyÂphenÂyl)acrylate
The title molÂecule, C15H20O4, has an E conformation about its C=C bond and is almost planar (r.m.s. deviation of all non-H atoms = 0.04 Å). The crystal structurere features O—H⋯O and C—H⋯O hydrogen bonds
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