13,353 research outputs found
Adaptive response to oxidative stress in the filamentous fungus Aspergillus niger B1-D
In the present study, we used a recombinant filamentous fungus strain, Aspergillus niger B1-D, as a model system, and investigated the antioxidant defences in this organism. Our findings indicate that pretreatment with low concentrations of H2O2 completely prevents killing by this oxidant at high concentrations. It shows that A. niger adapts to exposure to H2O2 by reducing growth and inducing a number of antioxidant enzyme activities, including superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, of which the induction of catalase is the most pronounced. Moreover the decline of these antioxidant enzymes activities after H2O2 detoxification, coincides with recommencement of growth. Results from monitoring the extracellular H2O2 concentration clearly indicate a very rapid detoxification rate for H2O2 in adapted A. niger cultures. A mathematical model predicts only very low concentrations of intracellular H2O2 accumulating in such cultures. Our results also show that glutathione plays a role in the oxidative defence against H2O2 in A. niger. On addition of H2O2, the intracellular pool of glutathione increases while the redox state of glutathione becomes more oxidized
Economic Effects of Lifting the Spring Load Restriction Policy in Minnesota
Spring load restrictions (SLR) regulate the weight per axle carried by heavy trucks during the spring thaw period. This policy aims to reduce pavement damage caused by heavy vehicles and extend the useful life of roads, but it also imposes costs on the trucking industry due to detouring or increased number of truckloads. Although the policies have been implemented for many years, their resulting economic effect has been unclear. The Minnesota Local Road Research Board (LRRB) and the Minnesota Department of Transportation (Mn/DOT) sponsored a cost/benefit study of spring load restrictions in Minnesota. The study, based on the results of surveys of industry costs, a pavement performance model, and a freight demand model, concludes that the benefits of lifting the existing SLR policy outweigh the additional costs. Roadways operating at 5-tons require additional study; however, current analysis warrants repealing SLR and keeping roadways operating year-round at 9-tons. The cost of additional damage should be recovered from those who benefit from the change in policy.
Skeletal Rigidity of Phylogenetic Trees
Motivated by geometric origami and the straight skeleton construction, we
outline a map between spaces of phylogenetic trees and spaces of planar
polygons. The limitations of this map is studied through explicit examples,
culminating in proving a structural rigidity result.Comment: 17 pages, 12 figure
Inner and Inter Label Propagation: Salient Object Detection in the Wild
In this paper, we propose a novel label propagation based method for saliency
detection. A key observation is that saliency in an image can be estimated by
propagating the labels extracted from the most certain background and object
regions. For most natural images, some boundary superpixels serve as the
background labels and the saliency of other superpixels are determined by
ranking their similarities to the boundary labels based on an inner propagation
scheme. For images of complex scenes, we further deploy a 3-cue-center-biased
objectness measure to pick out and propagate foreground labels. A
co-transduction algorithm is devised to fuse both boundary and objectness
labels based on an inter propagation scheme. The compactness criterion decides
whether the incorporation of objectness labels is necessary, thus greatly
enhancing computational efficiency. Results on five benchmark datasets with
pixel-wise accurate annotations show that the proposed method achieves superior
performance compared with the newest state-of-the-arts in terms of different
evaluation metrics.Comment: The full version of the TIP 2015 publicatio
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