Understanding Post-Sepsis Syndrome: How Can Clinicians Help?

Elisabeth C van der Slikke,1 Lise FE Beumeler,2,3 Madlene Holmqvist,4 Adam Linder,4 Robert T Mankowski,5 Hjalmar R Bouma1,6 1Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, 9713GZ, the Netherlands; 2Department of Intensive Care, Medical Centre Leeuwarden, Leeuwarden, 8934AD, the Netherlands; 3Department of Sustainable Health, Campus Fryslân, University of Groningen, Groningen, 8911 CE, the Netherlands; 4Department of Infection Medicine, Skåne University Hospital Lund, Lund, 221 84, Sweden; 5Department of Physiology and Aging, University of Florida, Gainesville, FL, 32610, USA; 6Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, 9713GZ, the NetherlandsCorrespondence: Hjalmar R Bouma, Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, P.O. Box 30.001, EB70, Groningen, 9700 RB, the Netherlands, Tel +31 (0) 50 361 7870, Email [email protected]: Sepsis is a global health challenge, with over 49 million cases annually. Recent medical advancements have increased in-hospital survival rates to approximately 80%, but the escalating incidence of sepsis, owing to an ageing population, rise in chronic diseases, and antibiotic resistance, have also increased the number of sepsis survivors. Subsequently, there is a growing prevalence of “post-sepsis syndrome” (PSS). This syndrome includes long-term physical, medical, cognitive, and psychological issues after recovering from sepsis. PSS puts survivors at risk for hospital readmission and is associated with a reduction in health- and life span, both at short and long term, after hospital discharge. Comprehensive understanding of PSS symptoms and causative factors is vital for developing optimal care for sepsis survivors, a task of prime importance for clinicians. This review aims to elucidate our current knowledge of PSS and its relevance in enhancing post-sepsis care provided by clinicians.Keywords: post-sepsis syndrome, sepsis, long-term outcom

E-waste Management and the Conservation of Geochemical Scarce Resources

Electrical and electronic equipment (EEE) generates very complex waste due to the wide variety of components such as metals, polymers, ceramic materials, and composite elements. In addition, the growing consumption of these devices due to technological development increases the rate they are disposed of. When improperly disposed of, waste electric and electronic equipment (WEEE) may trigger environmental impacts and negative effects on health. Also, the expansion of the electronic industry is based on the extraction of natural resources, some of which are running increasingly scarce. In this scenario, recycling stands as an alternative in the effort to recover economically interesting materials such as metals, which are abundant in waste electric and electronic equipment. This text discusses the current scenario in the electrical and electronic equipment industry and generation of waste electric and electronic equipment considering the implications of resource management and environment, social, and economic impact in this production chain