Chemical studies of the passivation of GaAs surface recombination using sulfides and thiols

Steady-state photoluminescence, time-resolved photoluminescence, and x-ray photoelectron spectroscopy have been used to study the electrical and chemical properties of GaAs surfaces exposed to inorganic and organic sulfur donors. Despite a wide variation in S2–(aq) concentration, variation of the pH of aqueous HS–solutions had a small effect on the steady-state n-type GaAs photoluminescence intensity, with surfaces exposed to pH=8, 0.1-M HS–(aq) solutions displaying comparable luminescence intensity relative to those treated with pH=14, 1.0-M Na2S·9H2O(aq). Organic thiols (R-SH, where R=–CH2CH2SH or –C6H4Cl) dissolved in nonaqueous solvents were found to effect increases in steady-state luminescence yields and in time-resolved luminescence decay lifetimes of (100)-oriented GaAs. X-ray photoelectron spectroscopy showed that exposure of GaAs surfaces to these organic systems yielded thiols bound to the GaAs surface, but such exposure did not remove excess elemental As and did not form a detectable As2S3 overlayer on the GaAs. These results imply that complete removal of As0 or formation of monolayers of As2S3 is not necessary to effect a reduction in the recombination rate at etched GaAs surfaces. Other compounds that do not contain sulfur but that are strong Lewis bases, such as methoxide ion, also improved the GaAs steady-state photoluminescence intensity. These results demonstrate that a general class of electron-donating reagents can be used to reduce nonradiative recombination at GaAs surfaces, and also imply that prior models focusing on the formation of monolayer coverages of As2S3 and Ga2S3 are not adequate to describe the passivating behavior of this class of reagents. The time-resolved, high level injection experiments clearly demonstrate that a shift in the equilibrium surface Fermi-level energy is not sufficient to explain the luminescence intensity changes, and confirm that HS– and thiol-based reagents induce substantial reductions in the surface recombination velocity through a change in the GaAs surface state recombination rate

A Scattered Light Echo around SN 1993J in M81

A light echo around SN 1993J was observed 8.2 years after explosion by a HST WFPC2 observation, adding to the small family of supernovae with light echoes. The light echo was formed by supernova light scattered from a dust sheet, which lies 220 parsecs away from the supernova, 50 parsecs thick along the line of sight, as inferred from radius and width of the light echo. The dust inferred from the light echo surface brightness is 1000 times denser than the intercloud dust. The graphite to silicate fraction can not be determined by our BVI photometric measurements, however, a pure graphite model can be excluded based on comparison with the data. With future observations, it will be possible to measure the expansion rate of the light echo, from which an independent distance to M81 can be obtained.Comment: 10 pages, 6 figures, in AASTeX format, submitted to ApJ Part

Treatment Buddies Improve Clinic Attendance among Women but Not Men on Antiretroviral Therapy in the Nyanza Region of Kenya.

Background. Kenyan antiretroviral (ART) guidelines encourage treatment buddies (TBy) to maximize treatment adherence. This study examined the effect of TBys on clinic attendance in men and women on ART. Methods. This retrospective cohort study included all adult patients initiating ART from August 2007 to December 2011 at four health facilities in Kenya. Data were abstracted from electronic medical records and analyzed using Poisson regression. Results. Of 2,430 patients, 2,199 (91%) had a TBy. Relationship between TBy and clinic attendance differed in females and males (interaction p = 0.09). After demographic and clinic factor adjustment, females with a TBy were 28% more likely to adhere to all appointments than those without (adjusted aRR = 1.28; 95% CI 1.08-1.53), whereas males were no more likely to adhere (aRR = 1.01; 95% CI 0.76-1.32). Males reported partner/spouse (33%) or brother (11%) as the TBy while females reported sister (17%), partner/spouse (14%), or another family member (12%). Multivariable analysis found no association between clinic attendance and TBy relationship in either gender. Conclusion. Clinic attendance was higher among women with TBys but not men. Results support TBys to help women achieve ART success; alternate strategies to bolster TBy benefits are needed for men

The emerging role of LRRK2 in tauopathies

Parkinson's disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse pathologies in patients with Parkinson's syndrome including tau pathology resembling progressive supranuclear palsy (PSP). The recent discovery that variation at the LRRK2 locus is associated with the progression of PSP highlights the potential importance of LRRK2 in tauopathies. Here, we review the emerging evidence and discuss the potential impact of LRRK2 dysfunction on tau aggregation, lysosomal function, and endocytosis and exocytosis

The Radial Structure of SNR N103B

We report on the results from a Chandra ACIS observation of the young, compact, supernova remnant N103B. The unprecedented spatial resolution of Chandra reveals sub-arcsecond structure, both in the brightness and in spectral variations. Underlying these small-scale variations is a surprisingly simple radial structure in the equivalent widths of the strong Si and S emission lines. We investigate these radial variations through spatially resolved spectroscopy using a plane-parallel, non-equilibrium ionization model with multiple components. The majority of the emission arises from components with a temperature of 1 keV: a fully ionized hydrogen component; a high ionization timescale (n_e*t > 10^12 s cm^-3) component containing Si, S, Ar, Ca, and Fe; and a low ionization timescale (n_e*t ~ 10^{11} s cm^-3) O, Ne, and Mg component. To reproduce the strong Fe Kalpha line, it is necessary to include additional Fe in a hot (> 2 keV), low ionization (n_e*t ~ 10^10.8 s cm^-3) component. This hot Fe may be in the form of hot Fe bubbles, formed in the radioactive decay of clumps of 56Ni. We find no radial variation in the ionization timescales or temperatures of the various components. Rather, the Si and S equivalent widths increase at large radii because these lines, as well as those of Ar and Ca, are formed in a shell occupying the outer half of the remnant. A shell of hot Fe is located interior to this, but there is a large region of overlap between these two shells. In the inner 30% of the remnant, there is a core of cooler, 1 keV Fe. We find that the distribution of the ejecta and the yields of the intermediate mass species are consistent with model prediction for Type Ia events.Comment: 34 pages, including 7 tables and 7 figures, Accepted by Ap

Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment

Coding mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene, which are associated with dominantly inherited Parkinson's disease (PD), lead to an increased activity of the encoded LRRK2 protein kinase. As such, kinase inhibitors are being considered as therapeutic agents for PD. It is therefore of interest to understand the mechanism(s) by which LRRK2 is activated during cellular signaling. Lysosomal membrane damage represents one way of activating LRRK2 and leads to phosphorylation of downstream RAB substrates and recruitment of the motor adaptor protein JIP4. However, it is unclear whether the activation of LRRK2 would be seen at other membranes of the endolysosomal system, where LRRK2 has also shown to be localized, or whether these signaling events can be induced without membrane damage. Here, we use a rapamycin-dependent oligomerization system to direct LRRK2 to various endomembranes including the Golgi apparatus, lysosomes, the plasma membrane, recycling, early, and late endosomes. Irrespective of membrane location, the recruitment of LRRK2 to membranes results in local accumulation of phosphorylated RAB10, RAB12, and JIP4. We also show that endogenous RAB29, previously nominated as an activator of LRRK2 based on overexpression, is not required for activation of LRRK2 at the Golgi nor lysosome. We therefore conclude that LRRK2 signaling to RAB10, RAB12, and JIP4 can be activated once LRRK2 is accumulated at any cellular organelle along the endolysosomal pathway

Correlative electrochemical microscopy of Li-Ion (De)intercalation at a series of individual LiMn2 O4 particles

The redox activity (Li‐ion intercalation/deintercalation) of a series of individual LiMn2O4 particles of known geometry and (nano)structure, within an array, is determined using a correlative electrochemical microscopy strategy. Cyclic voltammetry (current–voltage curve, I–E) and galvanostatic charge/discharge (voltage–time curve, E–t) are applied at the single particle level, using scanning electrochemical cell microscopy (SECCM), together with co‐location scanning electron microscopy that enables the corresponding particle size, morphology, crystallinity, and other factors to be visualized. This study identifies a wide spectrum of activity of nominally similar particles and highlights how subtle changes in particle form can greatly impact electrochemical properties. SECCM is well‐suited for assessing single particles and constitutes a combinatorial method that will enable the rational design and optimization of battery electrode materials

Scanning electrochemical cell microscopy : a versatile method for highly localised corrosion related measurements on metal surfaces

The development of tools that can probe corrosion related phenomena at the (sub)microscale is recognized to be increasingly important in order to understand the surface structural factors (grain orientation, inclusions etc.) that control the (electro)chemical stability (corrosion susceptibility, pitting, passivity etc.) of metal surfaces. Herein we consider the application of scanning electrochemical cell microscopy (SECCM), a relatively new member of the electrochemical droplet cell (EDC) family, for corrosion research and demonstrate the power of this technique for resolving structure and activity at the (sub)microscale. Hundreds of spatially-resolved (2 μm droplet size) potentiodynamic polarization experiments have been carried out on the several hours timescale and correlated to complementary structural information from electron backscatter diffraction (EBSD) and energy dispersive x-ray spectroscopy (EDS) in order to determine the effect of grain orientation and inclusions on electrochemical processes at low carbon steel in neutral solution (10 mM KNO3). Through this approach, it has been shown unequivocally that for the low index planes, anodic currents in the passive region (an indicator of corrosion susceptibility) are greatest on (101) planes compared to (100) and (111) planes. Furthermore, individual sub-micron MnS inclusions have been probed and shown to undergo active dissolution followed by rapid repassivation. This study demonstrates the high versatility of SECCM and the considerable potential of this technique for addressing structure-activity problems in corrosion and electromaterials science