Showcasing E-Book Platform Features

Faculty, students, and library staff are making increasingly nuanced use of e‐book collections, but the variance in e‐book attributes between publishers and platforms necessitates much more specific information about the various features of e‐books in order for patrons to make informed decisions. Librarians have been increasingly tasked with fielding questions ranging from the stability of links in syllabi, to the number of simultaneous users, download formats, soft ware requirements, and support for assistive technology. These new information needs have led the North Carolina State University (NCSU) Libraries to develop a public‐facing Web tool designed to help make the features, permissions, and use of our collection a little more transparent and accessible to patrons and library staff

Measurement of total and differential W + W − production cross sections in proton-proton collisions at s=8 \sqrt{s}=8 TeV with the ATLAS detector and limits on anomalous triple-gauge-boson couplings

The production of W boson pairs in proton-proton collisions at s=8 TeV is studied using data corresponding to 20.3 fb−1 of integrated luminosity collected by the ATLAS detector during 2012 at the CERN Large Hadron Collider. The W bosons are reconstructed using their leptonic decays into electrons or muons and neutrinos. Events with reconstructed jets are not included in the candidate event sample. A total of 6636 WW candidate events are observed. Measurements are performed in fiducial regions closely approximating the detector acceptance. The integrated measurement is corrected for all acceptance effects and for the W branching fractions to leptons in order to obtain the total WW production cross section, which is found to be 71.1 ± 1.1(stat) − 5.0+ 5.7(syst) ± 1.4(lumi) pb. This agrees with the next-to-next-to-leading-order Standard Model prediction of 63. 2− 1.4+ 1.6(scale) ± 1.2(PDF) pb. Fiducial differential cross sections are measured as a function of each of six kinematic variables. The distribution of the transverse momentum of the leading lepton is used to set limits on anomalous triple-gauge-boson couplings.[Figure not available: see fulltext.

De Novo Missense Variants in TRAF7 Cause Developmental Delay, Congenital Anomalies, and Dysmorphic Features

TRAF7 is a multi-functional protein involved in diverse signaling pathways and cellular processes. The phenotypic consequence of germ-line TRAF7 variants remains unclear. Here we report missense variants in TRAF7 in seven unrelated individuals referred for clinical exome sequencing. The seven individuals share substantial phenotypic overlap, with developmental delay, congenital heart defects, limb and digital anomalies, and dysmorphic features emerging as key unifying features. The identified variants are de novo in six individuals and comprise four distinct missense changes, including a c.1964G>A (p.Arg655Gln) variant that is recurrent in four individuals. These variants affect evolutionarily conserved amino acids and are located in key functional domains. Gene-specific mutation rate analysis showed that the occurrence of the de novo variants in TRAF7 (p = 2.6 x 10(-3)) and the recurrent de novo c.1964G>A (p.Arg655Gln) variant (p = 1.9 x 10(-8)) in our exome cohort was unlikely to have occurred by chance. In vitro analyses of the observed TRAF7 mutations showed reduced ERK1/2 phosphorylation. Our findings suggest that missense mutations in TRAF7 are associated with a multisystem disorder and provide evidence of a role for TRAF7 in human development