Bonding Social Capital in Entrepreneurial Developing Communities – Survival Networks or Barriers?

This paper focuses on the interaction between social capital and entrepreneurship in Aboriginal communities in Canada. Using statistical and interview data from three First Nations communities in northern Ontario, I examine if and how bonding networks turn into tangible resources for business development. The paper also highlights ways in which community relationships hinder entrepreneurship and turn into barriers to economic development. The paper concludes with examples of how insight into the interaction between public policy and social networks can help understand the barriers and opportunities facing community developers in marginalized communities around the world

Catch That Bus: Reverse-Commute Challenges Facing Low Income Inner-City Residents of Onondaga County

[Excerpt] Employer concerns about labor shortages for entry-level positions in the suburbs and outlying city neighborhoods prompted county planners to ask Cornell ILR to conduct this study. We organized a series of focus groups with low-income inner-city residents who commute to the suburbs or outlying city neighborhoods and work in health services, hospitality, or warehousing; we also spoke with several supervisors and a transportation planner. We found four major transportation challenges: limited service at non-standard times; out-of-synch schedules; off-schedule and off-route buses; and poorly located bus stops. We highlight several transportation initiatives that have been tried in other communities and propose a series of recommendations that transit planners, the transit company, and employers might consider in order to mitigate the reverse-commute challenges in ways that would benefit all stakeholders

Let\u27s Ride the Bus: Reverse-Commute Challenges Facing Low-Income Inner City Residents of Onondaga County (2009 Report)

This is the second and final phase of our investigation into the reverse-commute challenges facing low-income inner-city residents in Onondaga County. With lower-wage jobs proliferating outside the city core, our findings confirm that transportation remains one of the greatest obstacles to landing and keeping entry-level work. The current transit system does not meet the needs of low-income workers living in the city or employers based in outlying neighborhoods or the suburbs. Although a majority of manufacturing employers contacted for this study said transportation shortfalls do not affect their ability to hire and retain workers, other stakeholders jobseekers, job developers, service providers, county planners, and transit professionals—insist the problem is real: Jobseekers with few skills and limited access to transportation struggle to find employment while employers in other key sectors, notably hospitality and health services, contend with the consequences in the form of high turnover, tardiness, absences, and vacancies, as noted in our 2008 report, Catch That Bus... Inadequacies in the local transit system will affect the county\u27s longer-term economic vitality. Current concerns about air pollution, environmental conservation, energy costs, and strained municipal budgets add to the urgency of addressing the interrelated issues of employment, transportation, economic development, and sprawl. Collaboration among key stakeholders—the County, Centro, employers, private transit operators, service providers, and town boards--is necessary to advance the parties\u27 mutual interests

“Thanks to ‘X’ For Beta-ing!”: Fan Fiction Beta Readers in the Writing Center

In this thesis, I pose the question: what can we learn from fan fiction beta reading practices that can be applied to the writing center? Through interviews of writing center consultants who have had beta reading experiences, I consider what collaborative practices they have transferred into their writing center consultant skill sets. This project records how their affinity groups supported their literacy habits, and which dynamics of power and embodiment meant the most to them in these two discourse communities. Combining historic texts on what ideal writing center pedagogy looks like, I explore how writers could interact with acknowledgement of peer review and influence, the models of knowledge-sharing that shift and change with the power dynamic of novice and expert, and the othered-ness of affinity groups and writing centers through their feminine perceptions. Using the theory of feminist repurposing, I hypothesize that beta reading and writing centers both repurpose the traditional editorial process into the Burkean parlor/workshop, though sharing knowledge with the mutable dynamic of expertise. Advisor: Deborah Minte

SERVIÇO SOCIAL NO SISTEMA ÚNICO DE SAÚDE (SUS)

Como acadêmicas do curso de Bacharelado em Serviço Social nos dedicamos a buscar informações que nos dessem subsídios sobre as funções do Assistente Social, como atuantes no Sistema Único de Saúde (SUS), para sabermos de que forma podemos contribuir no âmbito da Saúde Pública, que tem deixado muito a desejar nos dias de hoje. A fim de atingirmos nossos objetivos, realizamos inúmeras leituras de obras literárias disponibilizadas em trabalhos e artigos científicos; livros, sites da Internet e outros recursos. O interesse do grupo deu-se em função de fatores evidenciados, de que deveríamos ampliar as noções sobre a relação saúde/doença, como decorrência das condições de vida e de trabalho, onde não se permite mais desconhecer a necessidade de ações de diferentes profissionais na área da saúde. Porém, nos dedicamos também a demonstrar que atualmente há espaço para o Serviço Social em meio à equipe atuante no funcionamento da Política de Saúde no Brasil, haja vista, que a partir da Constituição de 1988, a Saúde, a Assistência Social e a Previdência Social passaram a fazer parte integrante da Seguridade Social. E, além disso, também a Saúde e Assistência Social tiveram seu reconhecimento como um direito de cidadania e dever do Estado. Portanto, buscamos delinear alguns limites e possibilidades da relação Saúde Pública e Serviço Social que constituem os pareceres deste estudo

RECONHECIMENTO DOS ESPAÇOS DE ATUAÇÃO DO ASSISTENTE SOCIAL

Este trabalho se refere a um estudo sobre a atuação do Assistente Social no âmbito do Centro de Referênciada Assistência Social – CRAS no município de Lages - SC. Os dados da pesquisa foram coletados por meio de pesquisa bibliográfica e entrevista com a Assistente Social, tendo por objetivo verificar a dimensão técnico-operativa da intervenção profissional, buscamos apresentar a concepção dos CRAS, como também, fundamentar teoricamente as bases que sustentam a discussão do trabalho em rede

Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation

The literature on innovation and interactive learning has tended to emphasize the importance of local networks, inter-firm collaboration and knowledge flows as the principal source of technological dynamism. More recently, however, this view has come to be challenged by other perspectives that argue for the importance of non-local knowledge flows. According to this alternative approach, truly dynamic economic regions are characterized both by dense local social interaction and knowledge circulation, as well as strong inter-regional and international connections to outside knowledge sources and partners. This paper offers an empirical examination of these issues by examining the geography of knowledge flows associated with innovation in biotechnology. We begin by reviewing the growing literature on the nature and geography of innovation in biotechnology research and the commercialization process. Then, focusing on the Canadian biotech industry, we examine the determinants of innovation (measured through patenting activity), paying particular attention to internal resources and capabilities of the firm, as well as local and global flows of knowledge and capital. Our study is based on the analysis of Statistics Canada’s 1999 Survey of Biotechnology Use and Development, which covers 358 core biotechnology firms. Our findings highlight the importance of in-house technological capability and absorptive capacity as determinants of successful innovation in biotechnology firms. Furthermore, our results document the precise ways in which knowledge circulates, in both embodied and disembodied forms, both locally and globally. We also highlight the role of formal intellectual property transactions (domestic and international) in promoting knowledge flows. Although we document the importance of global networks in our findings, our results also reveal the value of local networks and specific forms of embedding. Local relational linkages are especially important when raising capital—and the expertise that comes with it—to support innovation. Nevertheless, our empirical results raise some troubling questions about the alleged pre-eminence of the local in fostering innovation

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration.

A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. Under homeostatic conditions, mutant macrophages accumulate undigested lysosomal material, which disrupts endocytic recycling and impairs their migration to, and thus engulfment of, dying cells. This causes a buildup of unengulfed cell debris. During mycobacterial infection, macrophages with lysosomal storage cannot migrate toward infected macrophages undergoing apoptosis in the tuberculous granuloma. The unengulfed apoptotic macrophages undergo secondary necrosis, causing granuloma breakdown and increased mycobacterial growth. Macrophage lysosomal storage similarly impairs migration to newly infecting mycobacteria. This phenotype is recapitulated in human smokers, who are at increased risk for tuberculosis. A majority of their alveolar macrophages exhibit lysosomal accumulations of tobacco smoke particulates and do not migrate to Mycobacterium tuberculosis. The incapacitation of highly microbicidal first-responding macrophages may contribute to smokers' susceptibility to tuberculosis.This work was supported by the National Institutes of Health (R37AI054503, LR, R01NS082567, CBM, 5F30HL110455, RB, 1DP2-OD008614, DMT), the Wellcome Trust (LR), the National Institute of Health Research Cambridge Biomedical Research Centre (LR), the Health Research Board of Ireland (HRA_POR/2013/387, MO’S and CSA/2012/16, JK), and The Royal City of Dublin Hospital Trust (Grant 146, JK).This is the final version of the article. It first appeared from Cell Press via http://dx.doi.org/10.1016/j.cell.2016.02.034

Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo.

The blockade of phagolysosomal fusion is considered a critical mycobacterial strategy to survive in macrophages. However, viable mycobacteria have been observed in phagolysosomes during infection of cultured macrophages, and mycobacteria have the virulence determinant MarP, which confers acid resistance in vitro. Here we show in mice and zebrafish that innate macrophages overcome mycobacterial lysosomal avoidance strategies to rapidly deliver a substantial proportion of infecting bacteria to phagolysosomes. Exploiting the optical transparency of the zebrafish, we tracked the fates of individual mycobacteria delivered to phagosomes versus phagolysosomes and discovered that bacteria survive and grow in phagolysosomes, though growth is slower. MarP is required specifically for phagolysosomal survival, making it an important determinant for the establishment of mycobacterial infection in their hosts. Our work suggests that if pathogenic mycobacteria fail to prevent lysosomal trafficking, they tolerate the resulting acidic environment of the phagolysosome to establish infection.National Institutes of Health (Grant IDs: R37AI054503, R01 AI076327, 5T32HD007233, 5F30HL110455), Wellcome Trust, National Institute of Health Research Cambridge Biomedical Research CentreThis is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.chom.2016.07.00

Zebrafish Infection: From Pathogenesis to Cell Biology

The study of host–pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counterparts. A wide variety of pathogenic bacteria have been investigated using zebrafish models, providing unprecedented resolution of the cellular response to infection in vivo. In this review, we illustrate how zebrafish models have contributed to our understanding of cellular microbiology by providing an in vivo platform to study host–pathogen interactions from the single cell to whole animal level. We also highlight discoveries made from zebrafish infection that hold great promise for translation into novel therapies for humans