How Kids Develop - Ages and Stages of Youth Development

Certain characteristics are common to Children at each age level. Although children differ in the rate at which they develop, the order of the stages does not vary. While it is extremely important to remember that every child is unique and special in his or her own right, some needs and interests are universal to all children to ensure successful development.</p

Be'an All you Can Be

This manual is packed with activities to help youth in grades 9 - 12 learn about integrated crop management, hybrid selection, profitability, safety, and harvesting. </p

Be\u27an All you Can Be

This manual is packed with activities to help youth in grades 9 - 12 learn about integrated crop management, hybrid selection, profitability, safety, and harvesting.https://lib.dr.iastate.edu/extension_pubs/1268/thumbnail.jp

Green and Growing

https://lib.dr.iastate.edu/extension_pubs/1266/thumbnail.jp

Serum Analyte Profiles Associated With Crohn's Disease and Disease Location

Background Crohn's disease (CD) can affect any segment of the digestive tract but is most often localized in the ileal, ileocolonic, and colorectal regions of the intestines. It is believed that the chronic inflammation in CD is a result of an imbalance between the epithelial barrier, the immune system, and the intestinal microbiota. The aim of the study was to identify circulating markers associated with CD and/or disease location in CD patients. Methods We tested 49 cytokines, chemokines, and growth factors in serum samples from 300 patients with CD and 300 controls. After quality control, analyte levels were tested for association with CD and disease location. Results We identified 13 analytes that were higher in CD patients relative to healthy controls and that remained significant after conservative Bonferroni correction (P < 0.0015). In particular, CXCL9, CXCL1, and interleukin IL-6 had the greatest effect and were highly significant (P < 5 x 10(-7)). We also identified 9 analytes that were associated with disease location, with VEGF, IL-12p70, and IL-6 being elevated in patients with colorectal disease (P < 3 x 10(-4)). Conclusions Multiple serum analytes are elevated in CD. These implicate the involvement of multiple cell types from the immune, epithelial, and endothelial systems, suggesting that circulating analytes reflect the inflammatory processes that are ongoing within the gut. Moreover, the identification of distinct profiles according to disease location supports the existence of a biological difference between ileal and colonic CD, consistent with previous genetic and clinical observations