The stepwise oxidation of indolino[2,1-b]oxazolidine derivatives

This work presents an original strategy to modulate the electrochemical properties of the indolino[2,1-b]oxazolidine core appropriately substituted in position 5 (para-substitution of the phenyl ring) by acceptor or donor groups (CHO, OMe, Me, F, H, Cl, Br). Supported by spectroelectrochemical experiments and confronted to electrochemical simulations, the stepwise oxidation of indolino[2,1-b]oxazolidine derivatives involves an electrochemical mechanism which depends on the para-substitution of the phenyl ring and leads to either the formation of a stable radical cation, the opening of the oxazolidine ring or an irreversible aryl C-C coupling

Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers

Advanced glycation end-products, namely AGEs, are involved in the pathogenesis of numerous diseases. If AGEs inhibitors are well-known, only few products are described as compounds able to destroy those deleterious products. In this work, we describe naphthoic acid derivatives, particularly 1-(naphthalen-1-yl)propane-1,2-dione 9, allowing the simple and rapid detection of AGEs breakers using a 96-well microplate fluorescence assay. Since the inaugurate publication about AGEs breakers whose activity was demonstrated using HPLC analysis, this work proposes the first assay suitable for automated and high throughput screening of AGEs breakers

Desorption/Ionization on self-Assembled Monolayer Surface (DIAMS) Evaluation of a New Matrix-Free Laser Desorption/Ionization method

Date du colloque&nbsp;: 06/2008</p

On making nD images well-composed by a self-dual local interpolation

International audienceNatural and synthetic discrete images are generally not well-composed, leading to many topological issues: connectivities in binary images are not equivalent, the Jordan Separation theorem is not true anymore, and so on. Conversely, making images well-composed solves those problems and then gives access to many powerful tools already known in mathematical morphology as the Tree of Shapes which is of our principal interest. In this paper, we present two main results: a characterization of 3D well-composed gray-valued images; and a counter-example showing that no local self-dual interpolation satisfying a classical set of properties makes well-composed images with one subdivision in 3D, as soon as we choose the mean operator to interpolate in 1D. Then, we briefly discuss various constraints that could be interesting to change to make the problem solvable in nD

A quasi-linear algorithm to compute the tree of shapes of n-D images

International audienceTo compute the morphological self-dual representation of images, namely the tree of shapes, the state-of-the-art algorithms do not have a satisfactory time complexity. Furthermore the proposed algorithms are only effective for 2D images and they are far from being simple to implement. That is really penalizing since a self-dual representation of images is a structure that gives rise to many powerful operators and applications, and that could be very useful for 3D images. In this paper we propose a simple-to-write algorithm to compute the tree of shapes; it works for \nD images and has a quasi-linear complexity when data quantization is low, typically 12~bits or less. To get that result, this paper introduces a novel representation of images that has some amazing properties of continuity, while remaining discrete

Supramolecular chemistry of helical foldamers at the solid-liquid interface: self-assembled monolayers and anion recognition

The synthesis of a redox-active helical foldamer and its immobilization onto a gold electrode are described. These large molecular architectures are grafted in a reproducible manner and provide foldamer-based self-assembled monolayers displaying recognition properties

Evidence of electrochemical transduction of cation recognition by TEMPO derivatives

This work reports the first example of electrochemical cation binding transduction via nitroxyl groups. It shows the possibility to transduce a complexation without a pi-conjugated bridge between the redox and the host moieties. As expected, we confirm that the host/redox probe distance is a key point for transduction