The molecular biology of feline immunodeficiency virus (FIV)

10.3390/v3112192Viruses3112192-221

Herpes simplex 1 encephalitis presenting as a brain haemorrhage with normal cerebrospinal fluid analysis: A case report

10.1186/1752-1947-2-387Journal of Medical Case Reports238

A novel combined RNA-protein interaction analysis distinguishes HIV-1 Gag protein binding sites from structural change in the viral RNA leader

10.1038/srep14369Scientific Reports51436

A new method for detecting signal regions in ordered sequences of real numbers, and application to viral genomic data

10.1371/journal.pone.0195763PLoS ONE134e019576

Rev: Beyond nuclear export

10.1099/vir.0.011460-0Journal of General Virology9061303-131

Identification of RNA helicases in human immunodeficiency virus 1 (HIV-1) replication - a targeted small interfering RNA library screen using pseudotyped and WT HIV-1

Central to the development of new treatments for human immunodeficiency virus 1 (HIV-1) is a more thorough understanding of the viral life cycle and the cellular cofactors upon which this depends. Targeting cellular proteins and their interaction with HIV-1 has the potential to reduce the problem of emerging viral resistance to drugs as mutational escape is more difficult. We performed a short interfering RNA (siRNA) library screen targeting 59 cellular RNA helicases, assessing the effect on both viral capsid protein production and infectious virion formation. Five RNA helicases were identified which, when knocked down, reproducibly decreased infectious particle production: DDX5, DDX10, DDX17, DDX28 and DDX52. Two of these proteins (DDX5 and DDX17) have known roles in HIV-1 replication. A further helicase (DDX10) was a positive hit from a previous genome-wide siRNA screen; however, DDX28 and DDX52 have not previously been implicated as essential cofactors for HIV-1

Identification of RNA helicases in human immunodeficiency virus 1 (HIV-1) replication – A targeted small interfering RNA library screen using pseudotyped and WT HIV-1

10.1099/vir.0.000092Journal of General Virology961484-148

HIV silencing and inducibility are heterogeneous and are affected by factors intrinsic to the virus

10.1128/mBio.00188-19mBio103e00188-1

Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production

10.1186/s12977-015-0197-xRetrovirology1217