3 research outputs found
The First Space-Based Gravitational-Wave Detectors
Gravitational waves provide a laboratory for general relativity and a window
to energetic astrophysical phenomena invisible with electromagnetic radiation.
Several terrestrial detectors are currently under construction, and a
space-based interferometer is envisioned for launch early next century to
detect test-mass motions induced by waves of relatively short wavelength.
Very-long-wavelength gravitational waves can be detected using the plasma in
the early Universe as test masses; the motion induced in the plasma by a wave
is imprinted onto the cosmic microwave background (CMB). While the signature of
gravitational waves on the CMB temperature fluctuations is not unique, the
polarization pattern can be used to unambiguously detect gravitational
radiation. Thus, forthcoming CMB polarization experiments, such as MAP and
Planck, will be the first space-based gravitational-wave detectors.Comment: 5 pages, 3 postscript figure
The identification of novel RNA structural motifs using COMPADRES: an automated approach to structural discovery
Recurring RNA structural motifs are important sites of tertiary interaction and as such, are integral to RNA macromolecular structure. Although numerous RNA motifs have been classified and characterized, the identification of new motifs is of great interest. In this study, we discovered four new conformationally recurring motifs: the π-turn, the Ω-turn, the α-loop and the C2′-endo mediated flipped adenosine motif. Not only do they have complex and interesting structures, but they participate in contacts of high biological significance. In a first for the RNA field, new motifs were discovered by a fully automated algorithm. This algorithm, COMPADRES, utilized a reduced representation of the RNA backbone and was highly successful at discerning unique structural relationships. This study also shows that recurring RNA substructures are not necessarily accompanied by consistent primary or secondary structure