Luminescence enhancement in dinuclear alkynylplatinum(II) complexes driven by Hierarchical Assembly through Pt···Pt and π-π stacking interactions

Poster: no. 1A luminescent dinuclear alkynylplatinum(II) complex containing an amphiphilic binaphthol bridge was designed and synthesized, and was shown to display cylindrical columnar assemblies in aqueous acetonitrile solutions, presumably mediated by the Pt•••Pt and π-π stacking interactions. The length of the binaphthol bridge was found to have a profound effect on the degree of helicity for hierarchical helices of helices and serves as a critical determinant in the formation of tertiary structures for foldamers. Interestingly, the reciprocal association of multiple helices has led to luminescence enhancement behavior, which provides a luminescence turn-on switch for the reporting of the hierarchical assembly of foldamers into higher-order structures, distinct from that of the pure organic systems. Such a transverse aggregation of multiple helices driven by metallophilic interactions has been studied by electronic absorption, circular dichroism, emission spectroscopy and electron microscopy.published_or_final_versio

以前瞻性雙盲隨機對照方式, 試驗香港華籍人士在進行經直腸超聲波導引的前列腺活組織切除術時, 使用含利多卡因的凝膠與純粹潤滑劑在止痛效用上的分別

OBJECTIVE. To compare the level of pain experienced by patients during transrectal ultrasound-guided prostatic biopsy using intrarectal 2% lidocaine gel versus plain lubricant gel. DESIGN. Prospective double-blind randomised controlled trial. SETTING. Regional hospital, Hong Kong. PATIENTS. From March 2002 to December 2003, patients who underwent ultrasound-guided prostate biopsy at a Geriatric Urology Centre. MAIN OUTCOME MEASURES. Pain and discomfort scores measured by horizontal visual analogue scales. RESULTS. A total of 338 consecutive patients were randomised to lidocaine gel or plain lubricant gel groups. The two groups were statistically similar in demographic and disease characteristics. There were no significant statistical differences in pain or discomfort score in the lidocaine gel and plain lubricant groups—pain score: 1.75 versus 1.79 (P=0.66) on day 0 and 0.21 versus 0.15 (P=0.97) on day 1; discomfort score: 0.79 versus 0.77 (P=0.86) on day 0 and 0.12 versus 0.12 (P=0.76) on day 1. No major complications were recorded in this cohort. CONCLUSIONS. Transrectal ultrasound-guided trucut biopsy of the prostate can be safely performed with no anaesthesia in Chinese patients. Pain and discomfort are minimal. It was found that 2% lidocaine gel has no statistical therapeutic or analgesic benefit over plain lubricant gel.published_or_final_versio

瑪麗醫院進行腹腔鏡腎臟切除術的早期經驗

OBJECTIVE: To report our early experience of laparoscopic nephrectomy. DESIGN: Prospective data collection. SETTING: Queen Mary Hospital, Hong Kong. PATIENTS: Transperitoneal laparoscopic nephrectomies were performed on 40 patients between July 1997 and December 2002. MAIN OUTCOME MEASURES: Demographic and perioperative data including operating time, blood loss, postoperative pain score, analgesic requirement, complications, time to resume oral intake, ambulatory state, and length of hospital stay. RESULTS: Laparoscopic nephrectomy was performed for 21 solid renal masses, five transitional cell carcinomas, and 14 non-functioning kidneys. Seven (17.5%) patients had previous abdominal surgery. The mean body mass index of the patients was 23.9 kg/m(2) and the mean operating time was 229 minutes. The mean estimated blood loss was 370 mL, and two patients required conversion to open surgery because of intra-operative bleeding. Other complications include diaphragmatic injury, port-site bleeding, chyle leakage, bleeding peptic ulcer, and myocardial ischaemia. The postoperative mean analgesic requirement was 26 mg of morphine sulphate equivalent. The mean time for patients to resume oral diet and full ambulation was 1.3 and 2.8 days, respectively, and the mean length of hospital stay was 6.7 days. The mean diameter of the solid renal tumour was 4.1 cm and the surgical margins of all resected specimen for malignant tumours were negative. CONCLUSION: Laparoscopic nephrectomy is a safe and efficacious approach for resection of benign non-functioning kidneys and malignant renal tumours.published_or_final_versio

Transformable Nanostructures of Luminescent Platinum-Containing Organosilane Hybrids: Non-Covalent Self- Assembly of Polyhedral Oligomeric Silsesquioxanes Assisted by Pt···Pt and π–π Stacking Interactions of Alkynylplatinum(II) Terpyridine Moieties

Poster Presentation: S9- Supramolecular Chemistry and Self-Assembly - no. S9.P

Hierarchical helices of helices directed by Pt•••Pt and Π- Π stacking Interactions: reciprocal association of multiple helices of dinuclear alkynylplatinum(II) complex with luminescence enhancement behavior

INORG-79A dinuclear alkynylplatinum(II) terpyridine complex containing an amphiphilic binaphthol bridge was designed and synthesized, and was shown to display cylindrical columnar assemblies in aqueous acetonitrile solutions, presumably mediated by the Pt···Pt and stacking interactions. The length of the binaphthol bridge was found to have a profound effect on the degree of helicity for hierarchical helices of helices and serves as a critical determinant in the formation of tertiary structures for foldamers. Interestingly, the reciprocal association of multiple helices has led to luminescence enhancement behavior, which provides a luminescence turn-on switch for the reporting of the hierarchical assembly of foldamers into higher-order structures, distinct from that of the pure organic systems. Such a transverse aggregation of multiple helices driven by metallophilic interactions has been studied by electronic absorption, circular dichroism, emission spectroscopy and electron microscopy

Synthesis, structural characterization, and photophysical study of luminescent face-to-face dinuclear platinum(II) alkynyl phosphine complexes and their tetranuclear mixed-metal platinum(II)-silver(I) and -copper(I) complexes

A series of luminescent face-to-face dinuclear platinum(II) alkynyl phosphine complexes with trimethoxyphenyl and carbazole moieties have been synthesized by phosphine exchange reaction. Two mixed-metal tetranuclear platinum(II)-silver(I) and -copper(I) complexes have also been synthesized. The complexes are well characterized by 1H, 13C, and 31P NMR spectroscopy, positive ion FAB mass spectrometry, IR spectroscopy, and elemental analysis. Most of them have been structurally characterized by X-ray crystallography. All the complexes are found to show emissive behavior. Correlations of the emissive property with the Pt⋯Pt distance, the nature of the alkynyl and bridging phosphine ligands, and the nature of the encapsulated metal ions on the alkynyl ligands have been made. TDDFT/CPCM calculations have been performed to provide further insight into the origin of the absorption and emission properties. © 2010 American Chemical Society.link_to_subscribed_fulltex

Single-turn helix-coil strands stabilized by metal ⋯metal and π-π Interactions of the alkynylplatinum(II) terpyridyl moieties in meta -phenylene ethynylene foldamers

Dinuclear alkynylplatinum(II) terpyridyl complexes with oligomeric bridge consisting of five repeating meta-phenylene ethynylene (mPE) units have been found to exhibit a strong tendency to fold back onto themselves to form short helical strands through the stabilization of Pt ⋯Pt and π-π interactions. The steric bulk of the terpyridine ligands and the length of the oligomeric bridge have been found to affect the extent of the intramolecular Pt ⋯Pt interaction that governs the stabilization of the short helical strand in solution. Their folding properties via Pt ⋯Pt and π-π stacking interactions have been studied by 1H NMR, 2D ROESY NMR, electronic absorption, and emission spectroscopies. © 2011 American Chemical Society.link_to_subscribed_fulltex