Examining Learning Disabilities in Schools through an Intersectional and Equitable Lens

This book chapter examines the intersection between learning disabilities (LD) and other marginalized identities to understand the diverse experiences of students with LDs and the disproportionalities that exist in LD identification and support in schools. Largely driven by the history and evolution of inclusion of disabilities in schools, Response to Intervention (RtI) arose as a model designed to increase academic performance among students with and without disabilities. Though RtI is a model shown to minimize inappropriate identification of LDs, intersectionality must be taken into consideration to understand the disproportionate representation of culturally and linguistically diverse (CLD) students in special education. Data from the National Assessment of Educational Progress suggest social factors (e.g. socioeconomic disadvantages, racial and ethnic intersection) as a potential cause for disproportionate representation and points to a need to further understand the disproportionality of different groups of students being over- or under-identified to receive special education services

Non-Invertible Symmetries, Brane Dynamics, and Tachyon Condensation

We study the Symmetry Topological Field Theory in holography associated with 4d $\mathcal{N}=1$ Super Yang-Mills theory with gauge algebra $\mathfrak{su}(M)$. From this, all the bulk symmetry operators are computed and matched to various D-brane configurations. The fusion algebra of the operators emerges from brane dynamics. In particular, we show that the symmetry operators are purely determined from the center-of-mass modes of the branes. We identify the TQFT fusion coefficients with the relative motion of the branes. We also establish the origin of condensation defects, arising from fusion of non-invertible operators, as the consequence of tachyon condensation in brane-anti-brane pairs.Comment: 39 pages plus appendice

M5-branes Probing Flux Backgrounds

We analyze the global symmetries and anomalies of 4d $\mathcal{N} = 1$ field theories that arise from a stack of $N$ M5-branes probing a class of flux backgrounds. These backgrounds consist of a resolved $\mathbb{C}^2 / \mathbb{Z}_k$ singularity fibered over a smooth Riemann surface of genus $g \geq 2$, supported by a non-trivial $G_4$-flux configuration labeled by a collection of $2(k-1)$ flux quanta, $\{N_i\}$. For $k=2$, this setup defines a non-trivial superconformal field theory (SCFT) in the IR, which is holographically dual to an explicit $AdS_5$ solution first described by Gauntlett, Martelli, Sparks, and Waldram. The generalization to $k \geq 3$ is hard to tackle directly within holography. Instead, in this paper we lay the groundwork for a systematic analysis of such a generalization by adopting anomaly inflow methods to identify continuous and discrete global symmetries of the 4d field theories. We also compute the 't Hooft anomalies for continuous symmetries at leading order in the limit of large $N$, $N_i$

A View from Anomalous Branes on Generalized Symmetries in Quantum Field Theory

The notion of symmetries in quantum field theory has undergone various revolutionary generalizations throughout the past decade. We explore in this dissertation with explicit examples how one can characterize higher-form symmetries and non-invertible symmetries from the perspective of branes in string/M-theory. Specifically, we make use of the anomalous topological actions of both the bulk supergravity and the brane worldvolume to study the global symmetry structure of the corresponding theories. The dissertation is divided into three main parts. In the first part, we analyze the global symmetries and anomalies of 4d $\mathcal{N} = 1$ field theories that arise from a stack of $N$ M5-branes probing a class of flux backgrounds. These backgrounds consist of a resolved $\mathbb{C}_2/\mathbb{Z}_k$ singularity fibered over a smooth Riemann surface, supported by a non-trivial $G_4$-flux configuration labeled by a collection of flux quanta. We lay the groundwork for a systematic analysis of such backgrounds by adopting anomaly inflow methods to identify the global symmetries of the 4d field theories. In the second part, we compare the 4d anomaly polynomials obtained respectively from reducing the anomaly polynomial of parent 6d $(1,0)$ superconformal field theories on a Riemann surface, and directly from eleven dimensions using the setup considered in the first part of the dissertation. We provide a geometric characterization of a class of modes that decouple along the renormalization group flow from six to four dimensions as operators originating from M2-branes wrapping resolution cycles. In the third part, we study the symmetry topological field theory in holography associated with 4d $\mathcal{N} = 1$ supersymmetric Yang-Mills theory with gauge algebra $\mathfrak{su}(M)$. From this, all the bulk symmetry operators are computed and matched to various D-brane configurations. The fusion algebra of the operators emerges from brane dynamics. In particular, we show that the symmetry operators are purely determined from the center-of-mass modes of the branes. We identify the fusion coefficients with the relative motion of the branes, and also establish the origin of condensation defects, arising from fusion of non-invertible operators, as the consequence of tachyon condensation in brane-anti-brane pairs

Magnification Bias of Distant Galaxies in the Hubble Frontier Fields: Testing Wave vs. Particle Dark Matter Predictions

Acting as powerful gravitational lenses, the strong lensing galaxy clusters of the deep Hubble Frontier Fields (HFF) program permit access to lower-luminosity galaxies lying at higher redshifts than hitherto possible. We analyzed the HFF to measure the volume density of Lyman-break galaxies at $z > 4.75$ by identifying a complete and reliable sample up to $z \simeq 10$. A marked deficit of such galaxies was uncovered in the highly magnified regions of the clusters relative to their outskirts, implying that the magnification of the sky area dominates over additional faint galaxies magnified above the flux limit. This negative magnification bias is consistent with a slow rollover at the faint end of the UV luminosity function, and indicates a preference for Bose-Einstein condensate dark matter with a light boson mass of $m_\mathrm{B} \simeq 10^{-22} \, \mathrm{eV}$ over standard cold dark matter. We emphasize that measuring the magnification bias requires no correction for multiply lensed images (with typically three or more images per source), whereas directly reconstructing the luminosity function will lead to an overestimate unless such images can be exhaustively matched up, especially at the faint end that is accessible only in the strongly lensed regions. In addition, we detected a distinctive downward transition in galaxy number density at $z \gtrsim 8$, which may be linked to the relatively late reionization reported by Planck. Our results suggests that JWST will likely peer into an "abyss" with essentially no galaxies detected in deep NIR imaging at $z > 10$.Comment: 46 pages, 23 figures, accepted for publication in Ap

The role of p53 in the alternation of vascular functions

Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system. During the aging process, normal functions of vascular cells and tissue progressively lost and eventually develop vascular diseases. Endothelial dysfunction, reduced bioavailability of endothelium-derived nitric oxide are usual phenomena observed in patients with cardiovascular diseases. Myriad of studies have been done to investigate to delay the vascular dysfunction or improve the vascular function to prolong the aging process. Tumor suppressor gene p53, also a transcription factor, act as a gatekeeper to regulate a number of genes to maintain normal cell function including but not limited to cell proliferation, cell apoptosis. p53 also crosstalk with other key transcription factors like hypoxia-inducible factor 1 alpha that contribute to the progression of cardiovascular diseases. Therefore, in recent three decades, p53 has drawn scientists’ attention on its effects in vascular function. Though the role of tumor suppressor gene p53 is still not clear in vascular function, it is found to play regulatory roles and may involve in vascular remodeling, atherosclerosis or pulmonary hypertension. p53 may have a divergent role in endothelial and vascular muscle cells in those conditions. In this review, we describe the different effects of p53 in cardiovascular physiology. Further studies on the effects of endothelial cell-specific p53 deficiency on atherosclerotic plaque formation in common animal models are required before the therapeutic potential can be realized

Patient Perception of Physician Attire Before and After Disclosure of the Risks of Microbial Contamination

Background: The white coat is traditionally considered to be the appropriate attire for physicians but it may also be contaminated with microbes and act as a potential source of infection. We aimed to study patients’ acceptance of physicians’ attire, their underlying reasons, and their reactions to an educational intervention with regards to the risks of contamination. Methods: We conducted a voluntary ques­tionnaire survey at a university teaching hospital in Hong Kong from February to July 2012. 262 patient-responses from adult inpatients and outpatients across various specialties were analysed. Results: White coats were highly favoured (90.8%) when compared with scrubs (22.1%), smart casual (7.6%) and formal (7.3%) wears. ’Professional image’ and ‘ease of identification’ were the main attributes of the white coat. Most patients (92.2%) would prefer doctors washing their white coats every few days, whilst 80.9% believed that doctors were actually doing so. After patients were informed of the potential risk of microbial contamination, white coats remained as the most favoured attire (66.4%), but with scrubs doubling in popularity (45.8%). Smart casual (9.2%) and formal attire (4.6%) remain the least accepted. Conclusion: Despite cross-infections being a significant concern within the healthcare environments, patients’ predominant acceptance and perceived attributes towards the white coat were maintained after an educational intervention on the risks of microbial contamination

A review of the pharmacological effects of Arctium lappa (burdock)

Abstract Arctium lappa, commonly known as burdock, is being promoted/recommended as a healthy and nutritive food in Chinese societies. Burdock has been used therapeutically in Europe, North America and Asia for hundreds of years. The roots, seeds and leaves of burdock have been investigated in view of its popular uses in traditional Chinese medicine (TCM). In this review, the reported therapeutic effects of the active compounds present in the different botanical parts of burdock are summarized. In the root, the active ingredients have been found to "detoxify" blood in terms of TCM and promote blood circulation to the skin surface, improving the skin quality/texture and curing skin diseases like eczema. Antioxidants and antidiabetic compounds have also been found in the root. In the seeds, some active compounds possess anti-inflammatory effects and potent inhibitory effects on the growth of tumors such as pancreatic carcinoma. In the leaf extract, the active compounds isolated can inhibit the growth of micro-organisms in the oral cavity. The medicinal uses of burdock in treating chronic diseases such as cancers, diabetes and AIDS have been reported. However, it is also essential to be aware of the side effects of burdock including contact dermatitis and other allergic/inflammatory responses that might be evoked by burdock

Retrotransposons Are the Major Contributors to the Expansion of the \u3ci\u3eDrosophila ananassae\u3c/i\u3e Muller F Element

The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it is substantially larger (\u3e18.7 Mb) in D. ananassae. To identify the major contributors to the expansion of the F element and to assess their impact, we improved the genome sequence and annotated the genes in a 1.4-Mb region of the D. ananassae F element, and a 1.7-Mb region from the D element for comparison. We find that transposons (particularly LTR and LINE retrotransposons) are major contributors to this expansion (78.6%), while Wolbachia sequences integrated into the D. ananassae genome are minor contributors (0.02%). Both D. melanogaster and D. ananassae F-element genes exhibit distinct characteristics compared to D-element genes (e.g., larger coding spans, larger introns, more coding exons, and lower codon bias), but these differences are exaggerated in D. ananassae. Compared to D. melanogaster, the codon bias observed in D. ananassae F-element genes can primarily be attributed to mutational biases instead of selection. The 5′ ends of F-element genes in both species are enriched in dimethylation of lysine 4 on histone 3 (H3K4me2), while the coding spans are enriched in H3K9me2. Despite differences in repeat density and gene characteristics, D. ananassae F-element genes show a similar range of expression levels compared to genes in euchromatic domains. This study improves our understanding of how transposons can affect genome size and how genes can function within highly repetitive domains

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London