Pemphigus acantholyticus paraneoplastic : literature review and case report

The article describes the clinical observation of a rare severe dermatosis, paraneoplastic acantholyticus pemphigus, associated with colon cancer with reference to pathogenesis, clinical variations and difficulties of diagnostics of this condition.Рассмотрены патогенез, клиническая картина, диагностика и лечение паранеопластической пузырчатки

Pemphigus acantholyticus paraneoplastic : literature review and case report

The article describes the clinical observation of a rare severe dermatosis, paraneoplastic acantholyticus pemphigus, associated with colon cancer with reference to pathogenesis, clinical variations and difficulties of diagnostics of this condition.Рассмотрены патогенез, клиническая картина, диагностика и лечение паранеопластической пузырчатки

Osteoporosis as a result of the long-term administration of glucocorticoids in patients suffering from acantholytic pemphigus

Goal – to study the prevalence of glucocorticoid-induced osteoporosis in patients suffering from acantholytic pemphigus and risk of osteoporosis-related fractures.Цель публикации – изучение распространенности глюкокортикоидного остеопороза у больных акантолитической пузырчаткой, риска остеопоротических переломов

Osteoporosis as a result of the long-term administration of glucocorticoids in patients suffering from acantholytic pemphigus

Goal – to study the prevalence of glucocorticoid-induced osteoporosis in patients suffering from acantholytic pemphigus and risk of osteoporosis-related fractures.Цель публикации – изучение распространенности глюкокортикоидного остеопороза у больных акантолитической пузырчаткой, риска остеопоротических переломов

The Effect of Stress on Menstrual Dysfunction in Female Students of Higher Educational Institutions in Moscow

Background: Gynecological morbidity in women of young reproductive age remains an urgent issue in modern medicine. Along with many adverse factors affecting the health of girls and young women, who should be considered as expectant mothers, stress takes one of the leading positions. Objective: To study the level of stress in female students with menstrual dysfunction. Materials and methods: 136 female students from 18 to 23 years old (average age 19.3 +/- 2.6 years). All of the participants completed a questionnaire compiled by the authors on the basis of standard questions in collecting general and gynecological anamnesis, criteria for diagnosing premenstrual syndrome, psychological stress scale PSM-25 (fully included, no changes), and Beck scale (fully included, no changes). The following features of the menstrual cycle were studied: cycle duration, menstruation duration, profusion, soreness, and regularity of menstruation as well as the presence of psychoemotional changes during the phase changes of the cycle. A systematic review was carried out of 25 studies (review articles, qualitative studies, questionnaires, retrospective and prospective studies) published in Russian and English from 2000 to 2019 (with a predominant including (88%) data for the last 10 years) using the PubMed, ScienceDirect, ProQuest and GoogleScholar databases. Results: 82.4% (n = 112) of the examined female students had various menstrual dysfunctions; the highest frequency was premenstrual syndrome (91.1%) and primary dysmenorrhea (85.7%). Students with high levels of stress and depression expressed significantly more often (p<0.05) with irregular rhythms of menstruation in comparison to the healthy group. Conclusions: It is recommended to physicians take into account the stress influence on gynecological pathology, while the awareness of young women about their health status should also be raised

Osteoporosis as a result of the long-term administration of glucocorticoids in patients suffering from acantholytic pemphigus

Goal. To study the prevalence of glucocorticoid-induced osteoporosis in patients suffering from acantholytic pemphigus and risk of osteoporosis-related fractures. Materials and methods. The study involved 26 patients including 12 patients suffering from acantholytic pemphigus. The patients underwent dual-energy X-ray absorptiometry (DXA) for calculating bone mineral density (BMD) as well as T and Z scores. To assess the ten-year probability (absolute risk) of fractures, the FRAX model was applied. Major results. Glucocorticoid-induced osteoporosis was diagnosed in 33.3% of the AP patients receiving a glucocorticoid therapy, and osteopenia was also diagnosed in 33.3% of them; an increased risk of osteoporosis-related fractures was observed in all of the patients over 40, which entails the need in early diagnostics of pathologic bone changes and prevention of complications such as osteoporosis-related fractures. Conclusion. A high share of complications (83.3%) related to systemic GCS stipulates the need in increased cooperation between dermatologists and allied specialists