12 research outputs found
707 ANALYSIS OF EFFICACY AND SAFETY OF TAPENTADOL EXTENDED RELEASE (ER) FOR CHRONIC LOW BACK PAIN BASED ON PRIOR OPIOID EXPERIENCE
Early post hatch nutrition on immune system development and function in broiler chickens
BUTYLATED HYDROXYANISOLE (BHA) INDUCED CHANGES IN THE SYNTHESIS OF POLAR LIPIDS AND IN THE MOLAR RATIO OF TETRAHYMANOL TO POLAR LIPIDS IN TETRAHYMENA PYRIFORMIS
Endophytic Root Colonization by Fusarium Species: Histology, Plant Interactions, and Toxicity
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol
Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To determine whether rare or low-frequency coding variants are associated with LDL-C, we exome sequenced 2,005 individuals, including 554 individuals selected for extreme LDL-C (>98th or <2nd percentile). Follow-up analyses included sequencing of 1,302 additional individuals and genotype-based analysis of 52,221 individuals. We observed significant evidence of association between LDL-C and the burden of rare or low-frequency variants in PNPLA5, encoding a phospholipase-domain-containing protein, and both known and previous