Immune Checkpoint Inhibitors in the Treatment of Lymphomas

Programmed death receptors and ligands (PD-1 and PD-L1) are the best studied immune checkpoints (ICP) and are considered to be key factors of immune response control. The ability of tumor cells to affect the ICP receptors is one of the principal mechanisms of suppressing antitumor immunity. The development of ICP inhibitors creates an opportunity to control and activate immune response and opens new perspectives for immunotherapy of cancers, including lymphomas. The paper reviews the biological background for the use of ICP inhibitors in the treatment of classical Hodgkin’s and non-Hodgkin’s lymphomas and summarizes the clinical experience of their use. The new approaches for the creation of combination regimens with ICP are also highlighted

A comparison study between electrospun polycaprolactone and piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds for bone tissue engineering

This study was supported by the Federal Target Program #14.587.21.0013 (a unique application number 2015-14-588-0002-5599)

Intracellular redox induced drug release in cancerous and mesenchymal stem cells

This work was supported by Russian Foundation of Basic Research grants No. 16-33-00966 mol_a, Russian Governmental Programm “Nauka”, N: 1.1658.2016 and by Government of the Russian Federation (grant № 14.Z50.31.0004) to support scientific research projects implemented under the supervision of leading scientists at Russian institutions and Russian institutions of higher education and Saratov State University

Triple-responsive inorganic-organic hybrid microcapsules as a biocompatible smart platform for the delivery of small molecules

crosscheck: This document is CrossCheck deposited related_data: Supplementary Information identifier: Alexander S. Timin (ORCID) copyright_licence: The Royal Society of Chemistry has an exclusive publication licence for this journal history: Received 4 September 2016; Accepted 7 October 2016; Accepted Manuscript published 10 October 2016; Advance Article published 28 October 2016; Version of Record published 16 November 2016This work was supported by the Russian Foundation of Basic Research grants no. 16-33-50153 mol_nr and no. 16-33-00966 mol_a, and Russian Governmental Program ‘‘Nauka’’, N: 1.1658.2016, 400

Efficient gene editing via non-viral delivery of CRISPR-Cas9 system using polymeric and hybrid microcarriers

The authors want to thank the UKE FACS Core Facility for expert assistance. We also thank Natalia Matveeva, who took the responsibilities for the fast process of the delivery of CRISPR–Cas9 plasmid. This work was supported by Russian Science Foundation (project No. 17‐73‐10023)

Mesenchymal Stem Cell Magnetization: Magnetic Multilayer Microcapsule Uptake, Toxicity, Impact on Functional Properties, and Perspectives for Magnetic Delivery.

Mesenchymal stem cells (MSCs) are widely used in cell therapy due to their convenience, multiline differentiation potential, reproducible protocols, and biological properties. The potential of MSCs to impregnate magnetic microcapsules and their possible influence on cell function and ability to response to magnetic field have been explored. Interestingly, the cells suspended in media show much higher ability in internalization of microcapsules, then MSCs adhere into the surface. There is no significant effect of microcapsules on cell toxicity compared with other cell line-capsule internalization reported in literature. Due to internalization of magnetic capsules by the cells, such cell engineering platform is responsive to external magnetic field, which allows to manipulate MSC migration. Magnetically sorted MSCs are capable to differentiation as confirmed by their conversion to adipogenic and osteogenic cells using standard protocols. There is a minor effect of capsule internalization on cell adhesion, though MSCs are still able to form spheroid made by dozen of thousand MSCs. This work demonstrates the potential of use of microcapsule impregnated MSCs to carry internalized micron-sized vesicles and being navigated with external magnetic signaling