Calcinosis cutis with siliconomas complicated by hypercalcemia

10.4158/EP.11.5.341Endocrine Practice115341 - 34

Automated generation of test programs from closed specifications of classes and test cases

Proceedings - International Conference on Software Engineering2696-105PCSE

Heuristic search with reachability tests for automated generation of test programs

Proceedings - 19th International Conference on Automated Software Engineering, ASE 2004282-28

Pre-operative serum alkaline phosphatase as a predictor for hypocalcemia post-parathyroid adenectomy

10.7150/ijms.4861International Journal of Medical Sciences97611 - 61

Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-B: Implication in breast cancer metastasis

10.1038/onc.2011.28Oncogene30283174-3185ONCN

Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells

The purpose of this study was to investigate the degree of chlorination of catechol (CAT) derivatives of pentachlorophenol (PCP) on the induction of cytotoxicity and DNA damaging effects in calf thymus DNA (ct-DNA) and in two human breast carcinoma cell lines. Results indicated that with the addition of the transition metal copper(II), increases in the amount of aldehydic DNA lesions (ADL) were detected in ct-DNA exposed to PCP-derived CATs over the corresponding control. The DNA lesions induced by various degrees of chlorination of PCP-derived CATs decrease in the rank order CAT congruent to 4-chlorocatechol (4-CICAT) > 4,5-dichlorocatechol (4,5-Cl(2)CAT) > 3,4,5-trichlorocatechol (3,4,5-Cl(3)CAT) > tetrachlorocatechol (Cl(4)CAT). In contrast, Cl(4)CAT was the only congeneric form of PCP-derived catechols that induced a significant increase in the number of ADL in human MCF-7 cells, and this only occurred when glutathione was depleted. Pretreatment with copper(I) and iron(II) chelators significantly reduced the formation of ADL in cells exposed to Cl(4)CAT. The data also indicated that the ADL induced by Cl(4)CAT in MCF-7 cells contain similar to70% putrescine excisable ADL. This evidence confirmed that the ADL induced by Cl(4)CAT in MCF-7 cells were derived from oxidative events. In addition, we demonstrated that the depletion of NAD(P)H in human T47D cells exposed to chlorinated CATs decreased in the rank order Cl(4)CAT much greater than 4-CICAT congruent to CAT. The depletion of NAD(P)H induced by Cl(4)CAT in T47D cells was partially blocked by catalase, superoxide dismutase, dimethyl sulfoxide, and copper(I) and iron(II) specific chelators. Additionally, the depletion of NAD(P)H in T47D cells exposed to Cl(4)CAT (1-10 muM) was completely blocked by three types of poly(ADP-ribose) polymerase-1 inhibitors. This evidence suggests that Cl(4)CAT induces an imbalance in DNA repair and the subsequent accumulation of DNA strand breaks in human cultured cells. Overall, these findings indicate that dechlorination may decrease the potentials of chlorinated catechols to induce oxidative DNA lesions and cytotoxic effects in living cells

Polyphenol-rich curry made with mixed spices and vegetables benefits glucose homeostasis in Chinese males (Polyspice Study): a dose-response randomized controlled crossover trial

10.1007/s00394-017-1594-9European Journal of Nutrition581301 - 31

Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways

10.1016/j.mce.2012.07.002Molecular and Cellular Endocrinology3621-Feb227 - 24

The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis

Development (Cambridge)1436950 - 96