100 research outputs found
Ethnic differences translate to inadequacy of high-risk screening for gestational diabetes mellitus in an Asian population: a cohort study
Background: universal and high-risk screening for gestational diabetes mellitus (GDM) has been widely studied and debated. Few studies have assessed GDM screening in Asian populations and even fewer have compared Asian ethnic groups in a single multi-ethnic population.Methods: 1136 pregnant women (56.7% Chinese, 25.5% Malay and 17.8% Indian) from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study were screened for GDM by 75-g oral glucose tolerance test (OGTT) at 26–28 weeks of gestation. GDM was defined using the World Health Organization (WHO) criteria. High-risk screening is based on the guidelines of the UK National Institute for Health and Clinical Excellence.Results: universal screening detected significantly more cases than high-risk screening [crude OR 2.2 (95% CI 1.7-2.8)], particularly for Chinese women [crude OR = 3.5 (95% CI 2.5-5.0)]. Pre-pregnancy BMI > 30 kg/m2 (adjusted OR = 3.4, 95% CI 1.5-7.9) and previous GDM history (adjusted OR = 6.6, 95% CI 1.2-37.3) were associated with increased risk of GDM in Malay women while GDM history was the only significant risk factor for GDM in Chinese women (adjusted OR = 4.7, 95% CI 2.0-11.0).Conclusion: risk factors used in high-risk screening do not sufficiently predict GDM risk and failed to detect half the GDM cases in Asian women. Asian women, particularly Chinese, should be screened to avoid under-diagnosis of GDM and thereby optimize maternal and fetal outcome
Fruit consumption and cardiovascular disease in China
10.1056/NEJMc1606624New England Journal of Medicine3755487 - 48
FTO Obesity Variant and Adipocyte Browning in Humans
10.1056/NEJMc1513316New England Journal of Medicine3742191 - 19
Basal insulin and cardiovascular and other outcomes
The New England journal of medicine367181763 - 176
Biologically inactive leptin and early-onset extreme obesity
10.1056/NEJMc1501146#SA1The New England journal of medicine37213126
PTEN haploinsufficiency, obesity, and insulin sensitivity
10.1056/NEJMc1212931New England Journal of Medicine367252450 - 245
Uric acid and cardiovascular risk
10.1056/NEJMc082360New England Journal of Medicine3605538 - 54
A mathematical model of pituitary-thyroid interaction to provide an insight into the nature of the thyrotropin-thyroid hormone relationship
10.1016/j.jtbi.2007.05.016Journal of Theoretical Biology2482275 - 28
Erratum: (Experimental and Clinical Endocrinology and Diabetes (2007) 115, (392-396))
10.1055/s-2007-993183Experimental and Clinical Endocrinology and Diabetes1151069
- …