Calibration of evolutionary diagnostics in high-mass star formation

The evolutionary classification of massive clumps that are candidate progenitors of high-mass young stars and clusters relies on a variety of independent diagnostics based on observables from the near-infrared to the radio. A promising evolutionary indicator for massive and dense cluster-progenitor clumps is the L/M ratio between the bolometric luminosity and the mass of the clumps. With the aim of providing a quantitative calibration for this indicator we used SEPIA/APEX to obtain CH3C2H(12-11) observations, that is an excellent thermometer molecule probing densities > 10^5 cm^-3 , toward 51 dense clumps with M>1000 solar masses, and uniformly spanning -2 < Log(L/M) < 2.3. We identify three distinct ranges of L/M that can be associated to three distinct phases of star formation in massive clumps. For L/M <1 no clump is detected in CH3C2H , suggesting an inner envelope temperature below 30K. For 1< L/M < 10 we detect 58% of the clumps, with a temperature between 30 and 35 K independently from the exact value of L/M; such clumps are building up luminosity due to the formation of stars, but no star is yet able to significantly heat the inner clump regions. For L/M> 10 we detect all the clumps, with a gas temperature rising with Log(L/M), marking the appearance of a qualitatively different heating source within the clumps; such values are found towards clumps with UCHII counterparts, suggesting that the quantitative difference in T - L/M behaviour above L/M >10 is due to the first appearance of ZAMS stars in the clumps.Comment: Astrophysical Journal Letters, Accepte

Fusion channels of non-Abelian anyons from angular-momentum and density-profile measurements

We present a method to characterize non-Abelian anyons that is based only on static measurements and that does not rely on any form of interference. For geometries where the anyonic statistics can be revealed by rigid rotations of the anyons, we link this property to the angular momentum of the initial state. We test our method on the paradigmatic example of the Moore-Read state, that is known to support excitations with non-Abelian statistics of Ising type. As an example, we reveal the presence of different fusion channels for two such excitations, a defining feature of non-Abelian anyons. This is obtained by measuring density-profile properties, like the mean square radius of the system or the depletion generated by the anyons. Our study paves the way to novel methods for characterizing non-Abelian anyons, both in the experimental and theoretical domains.Comment: 6+10 pages, 2+3 figures -- revised text and Supp. Mat. -- to be published in Phys. Rev. Let

Assessing the aesthetic attractivity of European butterflies: A web-based survey protocol

Aesthetic attractivity stands as an underestimated yet fundamental feature of species in conservation biology, significantly driving disproportionate protection efforts towards charismatic species. Despite the evidence, few attempts sought to precisely quantify the impact of aesthetic attractivity in defining priority of species for conservation actions (e.g. inclusion in International Union for Conservation of Nature red lists and protection lists). This study protocol describes the setting of an online test (available from April 2022 to April 2023 at www.unveiling.eu) designed to i) quantify the aesthetic attractivity to humans of the 496 European butterfly species and ii) identify which features (both in the perceived animal and in the perceiver) influence the aesthetic attractivity of a given butterfly species. The test is divided in 5 sections (personal data, ranking, single morphological features, emotional engagement, dispositional variables) aimed at profiling the relation each participant has with the species examined. In the long-term, evaluating butterflies' aesthetic attractivity could facilitate the critical assessment of current conservation strategies, such as the process of selection of flag and umbrella species by research institutions, environmental associations and Non Governative Organizations. This is expected to provide the much-needed evidence to set up unbiased biodiversity conservation strategies and counteract the selective anthropogenic pressure which favours the extinction of unattractive species, being no or less protected compared to charismatic species

Radiomics and Artificial Intelligence Can Predict Malignancy of Solitary Pulmonary Nodules in the Elderly

Solitary pulmonary nodules (SPNs) are a diagnostic and therapeutic challenge for thoracic surgeons. Although such lesions are usually benign, the risk of malignancy remains significant, particularly in elderly patients, who represent a large segment of the affected population. Surgical treatment in this subset, which usually presents several comorbidities, requires careful evaluation, especially when pre-operative biopsy is not feasible and comorbidities may jeopardize the outcome. Radiomics and artificial intelligence (AI) are progressively being applied in predicting malignancy in suspicious nodules and assisting the decision-making process. In this study, we analyzed features of the radiomic images of 71 patients with SPN aged more than 75 years (median 79, IQR 76–81) who had undergone upfront pulmonary resection based on CT and PET-CT findings. Three different machine learning algorithms were applied—functional tree, Rep Tree and J48. Histology was malignant in 64.8% of nodules and the best predictive value was achieved by the J48 model (AUC 0.9). The use of AI analysis of radiomic features may be applied to the decision-making process in elderly frail patients with suspicious SPNs to minimize the false positive rate and reduce the incidence of unnecessary surgery

HoBi-Like Pestivirus and Its Impact on Cattle Productivity

The clinical features and economic impact of the infection caused by an emerging group of pestiviruses, namely HoBi-like pestivirus, in a cattle herd of southern Italy are reported. In 2011, the virus was first associated with respiratory disease, causing an abortion storm after 1&nbsp;year and apparently disappearing for the following 3&nbsp;years after persistently infected calves were slaughtered. However, in 2014, reproductive failures and acute gastroenteritis were observed in the same herd, leading to a marked decrease of productivity. A HoBi-like strain closely related to that responsible for previous outbreaks was detected in several animals. Application of an intensive eradication programme, based on the detection and slaughtering of HoBi-like pestivirus persistently infected animals, resulted in a marked improvement of the productive performances

Synthesis and characterization of calcium hydroxide obtained from agave bagasse and investigation of its antibacterial activity

ABSTRACT Calcium hydroxide (Ca(OH)2) is recognized as an efficient bactericide and is widely applied as a root canal filler in endodontic treatment. Ca(OH)2 is mainly produced by hydration of calcium oxide (CaO), a product of the thermal decomposition of calcium carbonate (CaCO3) from sources such as limestone. In this work, calcium hydroxide particles were synthetized by the thermochemical transformation of waste biomass from the tequila industry. Agave biomass processed at 600 °C was composed mostly of calcium carbonate (CaCO3), while calcination at 900 °C followed by hydration produced Ca(OH)2. The morphology and crystalline nature of the Ca(OH)2 particles were characterized by micro-Raman spectroscopy, scanning electron microscopy and X-ray diffraction analysis. Bactericidal activity of synthesized calcium hydroxide was evaluated with the agar diffusion assay. Our results provide evidence that Ca(OH)2 obtained from agave biomass is an effective bactericidal against Escherichia coli and Enterococcus faecalis. Biomass from agave is available in Mexico and the rest of the American continent, the use of processed bagasse for medical applications could provide a venue for the useful disposition of industrial waste. Palabras clave: recursos renovables, ceniza, bactericida, Ca(OH)2 RESUMEN El hidróxido de calcio (Ca(OH)2) es reconocido como un eficiente bactericida y es ampliamente utilizado como relleno de la raíz dental en tratamientos de endodoncia. El Ca(OH)2 es producido por la hidratación del óxido de calcio (CaO), un producto de la descomposición térmica del carbonato de calcio (CaCO3), obtenido principalmente de piedra caliza. En el presente trabajo, se sintetizaron partículas de hidróxido de calcio mediante la descomposición térmica de biomasa residual de la industria tequilera. La biomasa de agave se procesó a 600 °C, la cual se compone principalmente de carbonato de calcio (CaCO3), por lo que su calcinación a 900 °C y posterior hidratación producen el Ca(OH)2. La morfología y cristalinidad de las partículas de Ca(OH)2 se caracterizaron mediante el uso de espectroscopía Raman, microscopio electrónico de barrido y difracción de rayos X. La actividad bactericida del hidróxido de calcio obtenido, se evaluó mediante el ensayo de difusión en agar. Los resultados proveen evidencia de la efectividad del Ca(OH)2, obtenido de la biomasa de agave, contra Escherichia coli y Enterococcus faecalis. La biomasa de agave se encuentra ampliamente disponible en México y el resto del continente americano, por lo que el uso de bagazo de agave procesado en aplicaciones médicas, puede proveer una alternativa en la disposición y el uso de residuos agroindustriales

Graz. Rosarium

Rosarium am Opernrin

MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro

PDGF enhances podosome formation and cell migration by regulating expression of the microRNAs miR-143 and -145, which target PDGF-R, PKC-ε, and fascin

SARS-CoV-2 and Skin: The Pathologist's Point of View

The SARS-CoV-2 pandemic has dramatically changed our lives and habits. In just a few months, the most advanced and efficient health systems in the world have been overwhelmed by an infectious disease that has caused 3.26 million deaths and more than 156 million cases worldwide. Although the lung is the most frequently affected organ, the skin has also resulted in being a target body district, so much so as to suggest it may be a real "sentinel" of COVID-19 disease. Here we present 17 cases of skin manifestations studied and analyzed in recent months in our Department; immunohistochemical investigations were carried out on samples for the S1 spike-protein of SARS-CoV-2, as well as electron microscopy investigations showing evidence of virions within the constituent cells of the eccrine sweat glands and the endothelium of small blood vessels. Finally, we conduct a brief review of the COVID-related skin manifestations, confirmed by immunohistochemistry and/or electron microscopy, described in the literature