City as lens: (re)imagining youth in Glasgow and Hong Kong

In recent years, a paradox has emerged in the study of youth. On the one hand, in the context of the processes of globalization, neoliberalism and precarity, the patterning of leisure and work for young people is becoming increasingly convergent across time and space. On the other hand, it is clear that young people’s habits and dispositions remain deeply tied to local places, with global processes filtered and refracted through specific cultural contexts. Against this backdrop, drawing on an Economic and Social Research Council/Research Grants Council (ESRC/RGC)-funded study of contemporary youth in Glasgow and Hong Kong, this article seeks to explore the role of the city as a mediating lens between global forces and local impacts. Utilizing both historical and contemporary data, the article argues that despite parallels in the impact of global forces on the structure of everyday life and work, young people’s leisure habits remain rooted in the fates and fortunes of their respective cities

Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study

IntroductionNipocalimab is a high-affinity, fully human, aglycosylated, effectorless, immunoglobulin G (IgG) 1 monoclonal antibody that targets the neonatal Fc receptor (FcRn), decreases systemic IgG including autoantibodies, and is under development in several IgG autoantibody- and alloantibody-mediated diseases, including generalized myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, maternal-fetal medicine, and multiple other therapeutic areas. An initial phase 1 study with single and multiple ascending doses of nipocalimab infused intravenously (IV) over 2 h demonstrated dose-dependent serum pharmacokinetics and IgG reductions, with an adverse event (AE) profile comparable to placebo.MethodsThe current investigation evaluates the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of nipocalimab across various IV infusion rates in a randomized, double-blind, placebo-controlled, sequential-dose study. Forty participants were randomized to receive nipocalimab 30 mg/kg over 60, 30, 15 or 7.5 min (0.5, 1, 2, or 4 mg/kg/min); nipocalimab 60 mg/kg over 15 min (4 mg/kg/min); or matching placebo.ResultsAt doses up to 60 mg/kg and infusion rates up to 4 mg/kg/min (maximum clinically feasible rate), single doses of nipocalimab were tolerable, with 12 (40%) participants experiencing AEs across nipocalimab cohorts compared with 1 (10%) participant in the placebo cohort. AEs deemed treatment related occurred in 6 (20%) participants receiving nipocalimab and 1 (10%) participant receiving placebo. None of the AEs were severe, and no participants discontinued treatment due to AEs. Nipocalimab provided consistent, dose-dependent serum pharmacokinetics and IgG reductions, regardless of infusion rate.DiscussionThis study supports the use of shortened durations of nipocalimab infusion for future studies

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

Data-driven modeling was used to analyze the complex signaling dynamics that connect DNA repair with cell survival, cell-cycle arrest, or apoptosis. This analysis revealed an unexpected role for Erk in G1/S arrest and apoptotic cell death following doxorubicin-induced DNA damage

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Effects of Tai chi exercises on adults with metabolic syndrome: a systematic review protocol

Background: Metabolic syndrome is a cluster of metabolic disturbances that increases the likelihood of developing cardiovascular diseases, type 2 diabetes mellitus, and mortality. The economic burden of metabolic syndrome in individuals with hypertension is projected to rise by 179% by 2020 (Wille et al., 2011). Although pharmacological and non-pharmacological management options including herbal medicine and lifestyle and dietary modifications appear to be effective, the numerous potential adverse effects may deter its use (Mallappa et al., 2012). Aim: This systematic review aims to present the best available research evidence related to the effectiveness of Tai Chi Exercises on community-dwelling adults with metabolic syndrome. The specific review questions to be addressed include the effectiveness of Tai Chi exercises on physiological and psychosocial outcomes among community-dwelling adults with metabolic syndrome; and the effectiveness of different types, duration, and frequency of Tai Chi exercises on client outcomes. Methods: All published and unpublished studies in both English and Chinese will be searched using a three-stage approach. The English databases to be searched include MEDLINE, CINAHL, Allied and Complementary Medicine, British Nursing Index, EBSCOhost, EMBASE, Health and Medical Complete, Health Sciences, ProQuest, PsycINFO, PsycArticles, Science Citation Index, Science Direct, Scopus, and SPORTDiscus. The Chinese databases to be searched include China Journal Net, Chinese Biomedical Literature Database, MyRead, Taiwan Electronic Periodical Services, and WanFang Data. Two reviewers will independently review the articles and chose those to be included based on the inclusion and exclusion criteria. The methodological quality of included studies will be assessed and details of all included studies will be extracted by two reviewers. If appropriate, quantitative results of comparable studies will be pooled in statistical meta-analysis. Narrative summary will be provided when statistical pooling is not possible. Conclusion: This systematic review protocol describes the methods and steps necessary to conduct a systematic review on the effectiveness of Tai Chi Exercises on client outcomes. The review will provide useful guidance for healthcare providers to choose the most suitable and effective alternative intervention for the community-dwelling adults with metabolic syndrome

(Re)Politicising young people: from Scotland’s Indyref to Hong Kong’s Umbrella Movement

No abstract available

Astaxanthin Influence on Health Outcomes of Adults at Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

The use of medication is effective in managing metabolic syndrome (MetS), but side effects have led to increased attention on using nutraceuticals and supplements. Astaxanthin shows positive effects in reducing the risk of MetS, but results from individual studies are inconclusive. This systematic review summarizes the latest evidence of astaxanthin in adults with risk factors of MetS. A systematic search of English and Chinese randomized controlled trials in 14 electronic databases from inception to 30 June 2021 was performed. Two reviewers independently screened the titles and abstracts, and conducted full-text review, quality appraisal, and extraction of data. Risk of bias was assessed by PEDro. A total of 7 studies met the inclusion criteria with 321 participants. Six studies were rated to have excellent methodological quality, while the remaining one was rated at good. Results show marginal effects of astaxanthin on reduction in total cholesterol and systolic blood pressure, and a significant attenuating effect on low-density lipoprotein cholesterol. Further robust evidence is needed to examine the effects of astaxanthin in adults at risk of MetS