278 research outputs found
Wertigkeit nuklearmedizinischer und endokrinologischer Methoden zur Klassifizierung autonomer Schilddrüsenadenome
Bacterial viruses enable their host to acquire antibiotic resistance genes from neighbouring cells
Prophages are quiescent viruses located in the chromosomes of bacteria. In the human
pathogen, Staphylococcus aureus, prophages are omnipresent and are believed to be responsible
for the spread of some antibiotic resistance genes. Here we demonstrate that release of
phages from a subpopulation of S. aureus cells enables the intact, prophage-containing
population to acquire beneficial genes from competing, phage-susceptible strains present in
the same environment. Phage infection kills competitor cells and bits of their DNA are
occasionally captured in viral transducing particles. Return of such particles to the prophagecontaining
population can drive the transfer of genes encoding potentially useful traits such
as antibiotic resistance. This process, which can be viewed as ‘auto-transduction’, allows
S. aureus to efficiently acquire antibiotic resistance both in vitro and in an in vivo virulence
model (wax moth larvae) and enables it to proliferate under strong antibiotic selection
pressure. Our results may help to explain the rapid exchange of antibiotic resistance genes
observed in S. aureus
Änderung des 127J-Gehaltes der Schilddrüse und der Schilddrüsenfunktion nach einmaliger Jodinkorporation bei Schilddrüsengesunden und Strumaträgern mit endemischem Jodmangel
Iodine contamination as a cause of hyperthyroidism or lack of TSH response to TRH Stimulation
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