8 research outputs found
Fulminating varicella despite prophylactic immune globulin and intravenous acyclovir in a renal transplant recipient: should renal patients be vaccinated against VZV before transplantation?
Contribution of the cornea to cytokine levels in the whole eye induced during the early phase of Pseudomonas aeruginosa
Cancer-testis antigen cyclin A1 is broadly expressed in ovarian cancer and is associated with prolonged time to tumor progression after platinum-based therapy
Healthcare costs and utilization associated with high-risk prescription opioid use: a retrospective cohort study
The Role of Nucleosomes in Epigenetic Gene Regulation
Chromatin is a dynamic and highly organised structure that plays a role in all aspects of chromatin biology and controls access to DNA. The basic repeating unit of chromatin is the nucleosome, an octamer of histone proteins wrapped around twice with DNA. Transcriptional gene regulation is largely controlled by the epigenetic regulation of the nucleosome, both through the position of the nucleosome in the DNA and chemical modifications to the histone proteins within the nucleosome core. In this chapter, we discuss the role of the nucleosome in controlling gene regulation at promoters, enhancers and in gene bodies. We also discuss the role of bivalent chromatin and asymmetric nucleosomes at these elements. While the focus of this chapter is on transcriptional regulation, many of the concepts also extend to other aspects of chromatin biology including DNA repair and replication