54 research outputs found
Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer
- Author
- Ammerpohl Ole (Institute of Human Genetics, Christian Albrechts University & University Hospital Schleswig-Holstein - Campus Kiel)
- Bergmann Anke K. (Institute of Human Genetics, Christian Albrechts University & University Hospital Schleswig-Holstein - Campus Kiel)
- Bernhart Stephan H. (Chair of Bioinformatics, Leipzig University)
- Doose Gero (Chair of Bioinformatics, Leipzig University)
- Hoffmann Steve (Chair of Bioinformatics, Leipzig University)
- Holdt Lesca M. (Institute of Laboratory Medicine, Ludwig-Maximilians-University)
- Jühling Frank (Chair of Bioinformatics, Leipzig University)
- Kretzmer Helene (Chair of Bioinformatics, Leipzig University)
- Northoff Bernd H. (Institute of Laboratory Medicine, Ludwig-Maximilians-University)
- Siebert Reiner (Institute of Human Genetics, Christian Albrechts University & University Hospital Schleswig-Holstein - Campus Kiel)
- Stadler Peter F. (Department of Theoretical Chemistry, Faculty of Chemistry, University of Vienna)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only lowly methylated in normal cells, but frequently shows elevated methylation levels in cancer samples. Here, we developed a universal classifier built from chromatin data that can identify cancer samples solely from hypermethylation of bivalent chromatin. Tested on over 7,000 DNA methylation data sets from several cancer types, it reaches an AUC of 0.92. Although higher levels of DNA methylation are often associated with transcriptional silencing, counter-intuitive positive statistical dependencies between DNA methylation and expression levels have been recently reported for two cancer types. Here, we re-analyze combined expression and DNA methylation data sets, comprising over 5,000 samples, and demonstrate that the conjunction of hypermethylation of bivalent chromatin and up-regulation of the corresponding genes is a general phenomenon in cancer. This up-regulation affects many developmental genes and transcription factors, including dozens of homeobox genes and other genes implicated in cancer. Thus, we reason that the disturbance of bivalent chromatin may be intimately linked to tumorigenesis
Retrograde Ascending Aortic Dissection During or After Thoracic Aortic Stent Graft Placement Insight From the European Registry on Endovascular Aortic Repair Complications
- Author
- AACHEN
- AUSTRIA MARTIN CZERNY
- BARCELONA
- BARI
- BERNE
- BOLOGNA
- BORTONE Alessandro Santo
- CARDIOVASCULAR CENTER E. MALAN
- CATHARINA HOSPITAL
- CENTRE HOSPITALIER UNIVERSITAIRE
- CENTRE HOSPITALIER UNIVERSITAIRE
- CHINA WEIGUO FU
- CHRU DE LILLE
- CHUV LAUSANNE
- COPENHAGEN
- DENMARK LARS LONN
- DENMARK PER JUSTESEN
- DENMARK SVEN JUST
- DEPARTMENT OF CARDIOVASCULAR SURGERY
- EINDHOVEN
- ESSEN
- EUROPEAN VASCULAR CENTER AACHEN MAASTRICHT
- FRANCE HERVE ROUSSEAU
- FRANCE JEAN PAUL BEREGI
- FRANCE PATRICE BERGERON
- FRANCE PHILLIPE PIQUET
- FUDAN UNIVERSITY
- GENTOFTE HOSPITAL
- GERMANY ANDREJ SCHMIDT
- GERMANY DITTMAR BOCKLER
- GERMANY ERNST WEIGANG
- GERMANY HOLGER EGGEBRECHT
- GERMANY STEPHAN LANGER
- HEIDELBERG
- HELLERUP
- HOPITAL CARDIOLOGIQUE
- HOPITAL DE RANGUEIL
- HOPITAL SAINT JOSEPH
- HOPITAL SAINTE MARGUERITE
- HOSPITAL CLINIC
- IRCCS
- ITALY FABIO VERZINI
- ITALY ROSELLA FATTORI
- ITALY SANTI TRIMARCHI
- LEIPZIG
- LEIPZIG HEART CENTER
- LONDON
- MAINZ
- MALMO
- MALMO UNIVERSITY HOSPITAL
- MARSEILLE
- MARSEILLE
- NIEUWEGEIN
- NORTHERN GENERAL HOSPITAL
- ODENSE
- ODENSE UNIVERSITY HOSPITAL
- PERUGIA
- RAIMUND ERBEL
- RIGSHOSPITALET UNIVERSITY HOSPITAL
- SAN DONATO MILANESE
- SCHOOL OF MEDICINE
- SHANGHAI
- SHEFFIELD
- SPAIN VICENTE RIAMBAU
- ST ANTONIUS HOSPITAL
- ST GEORGES HOSPITAL NHS TRUST
- ST GEORGES VASCULAR INSTITUTE
- SWEDEN MARTIN MALINA
- SWEDEN RICKARD NYMAN
- SWITZERLAND JURG SCHMIDLI
- SWITZERLAND PIERGIORGIO TOZZI
- THE NETHERLANDS HENCE VERHAGEN
- THE NETHERLANDS JAAP BUTH
- THE NETHERLANDS ROBIN HEIJMEN
- THORACIC INSTITUTE
- TOULOUSE
- UNITED KINGDOM MATT THOMPSON
- UNITED KINGDOM PETER GAINES
- UNIVERSITY HOSPITAL AACHEN
- UNIVERSITY HOSPITAL BERNE
- UNIVERSITY HOSPITAL MAINZ
- UNIVERSITY HOSPITAL S. ORSOLA
- UNIVERSITY MEDICAL CENTER UTRECHT
- UNIVERSITY OF BARCELONA
- UNIVERSITY OF BARI
- UNIVERSITY OF COPENHAGEN
- UNIVERSITY OF DUISBURG ESSEN
- UNIVERSITY OF HEIDELBERG
- UNIVERSITY OF PERUGIA
- UNIVERSITY OF VIENNA MEDICAL SCHOOL
- UPPSALA
- UPPSALA UNIVERSITY HOSPITAL
- UTRECHT
- VASCULAR CENTER MALMO LUND
- VIENNA
- WEST GERMAN HEART CENTER ESSEN
- ZHONGSHAN HOSPITAL
- ZHUI DONG
- Publication venue
- Publication date
- 01/01/2009
- Field of study
Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
- Author
- Aalborg University Hospital
- Aarhus University Hospital
- Abu-Freha Naim
- AC Camargo Hospital
- Ahadova Aysel
- Ajuntament de L’Hospitalet
- Alvarez-Valenzuela Karin
- Amor David
- Ankathil Ravindran
- Aretz Stefan
- Arizona State University
- Arnold Julie
- Aronson Melyssa
- Backman Ann-Sofie
- Barca-Tierno Verónica
- Bassaneze Thiago
- Ben-Gurion University of the Negev
- Bernstein Inge
- Bertario Lucio
- Bohorquez Mabel
- Bonanni Bernardo
- Brunet Joan
- Buchanan Daniel D.
- Burn John
- Büttner Reinhard
- Caldés Trinidad
- Capella Gabriel
- Cardiff University
- Carraro Dirce Maria
- Catholic University Of Korea St. Vincent's Hospital
- Cavestro Giulia Martina
- Center for Medical Genetics and Primary Health Care
- Central Finland Health Care District
- Central University of Venezuela
- Chen-Shtoyerman Rakefet
- Copenhagen University Hospital
- Creighton University
- Crosbie Emma J.
- da Silva Leandro Apolinário
- de Vargas Aída Falcón
- Department of Architecture Design and Media Technology
- Department of Clinical Genetics
- Department of Clinical Medicine
- Department of Electronic Systems
- Department of Gastrointestinal Surgery
- Department of Molecular Diagnostics
- Dominguez-Valentin Mev
- Dowty James G.
- Dueñas Nuria
- Duijkers Floor
- Duke NUS Graduate Medical School
- Dębniak Tadeusz
- Engel Christoph
- Esperon Patricia
- Evans Dafydd Gareth
- Figueiredo Jane
- Fox Chase Cancer Center
- Fred Hutchinson Cancer Research Center
- Gallinger Steven
- Garre Pilar
- Geisinger Medical Center
- Gerdes Anne-Marie
- German Cancer Research Center
- Gluck Nathan
- Green Kate
- Greenblatt Marc
- Guillem Jose G.
- Guillén-Ponce Carmen
- Half Elizabeth
- Hall Michael J.
- Hampel Heather
- Haupt Saskia
- Hebrew University of Jerusalem
- Heidelberg Institute for Theoretical Studies
- Heidelberg University
- Heinimann Karl
- Helsinki University Hospital
- Heuveline Vincent
- Holinski-Feder Elke
- Hoogerbrugge Nicoline
- Hopper John L.
- Horisberger Karoline
- Hospital Clínico San Carlos
- Hospital de Câncer de Barretos
- Hospital Italiano de Buenos Aires
- Hospital Privado Centro Médico de Córdoba
- Hospital Sírio-Libanês
- Hospital Universitario Ramón y Cajal
- Hovig Eivind
- Hüneburg Robert
- Imperial College London
- Instituto Nacional de Cancerologia
- Institutsekretariat
- IRCCS Istituto Europeo di Oncologia - Milano
- James Paul
- Jenkins Mark A.
- John Thomas
- Kalfayan Pablo
- Kariv Revital
- Karolinska Institutet
- Karolinska University Hospital
- Katz Lior
- Kennelly Rory
- Klinik Diagnostik
- Klinik Kirurgi og Kræftbehandling
- Kloor Matthias
- Kohonen-Corish Maija R. J.
- Laghi Luigi
- Laish Ido
- Lalloo Fiona
- Latchford Andrew
- Lautrup Charlotte K.
- Le Marchand Loïc
- Lee Grant
- Leiden University Medical Center
- Leipzig University
- Lepisto Anna
- Levi Zohar
- Ligtenberg Marjolijn J. L.
- Lindberg Lars Joachim
- Lindblom Annika
- Lindor Noralane
- Lino-Silva Leonardo S.
- Loeffler Markus
- Lopez-Koestner Francisco
- Lubiński Jan
- Ludwig Maximilian University of Munich
- Macrae Finlay
- Maharaja Sayajirao University of Baroda
- Manchester University NHS Foundation Trust
- Martin Claudia
- Mayo Clinic Jacksonville FL
- Mecklin Jukka-Pekka
- Mints Miriam
- Monahan Kevin
- Monash University
- Morrison Patrick J.
- Moslein Gabriela
- Møller Pål
- Nakken Sigve
- Nascimento Ivana
- Neffa Florencia
- Newcastle University
- Newcomb Polly A.
- Newton Katie
- Ngeow Joanne
- Nielsen Maartje
- Ohio State University
- Okkels Henrik
- Pai Rish
- Palmero Edenir
- Parma University Hospital
- Parry Susan
- Pavicic Walter Hernán
- Peltomäki Päivi
- Perne Claudia
- Peter Maccallum Cancer Centre
- Pineda Marta
- Plazzer John-Paul
- Pomeranian Medical University in Szczecin
- Poplawski Nicola
- Portenkirchner Carmen
- Pylvänäinen Kirsi
- Queen's University Belfast
- Rabin Medical Center Israel
- Radboud University Nijmegen Medical Centre
- Rahner Nils
- Rambam Health Care Campus Israel
- Rasmussen Lene J.
- Redler Silke
- Reece Jeanette
- Renkonen-Sinisalo Laura
- Ricciardiello Luigi
- Rigshospitalet Copenhagen University Hospital
- Rosner Guy
- Rossi Benedito Mauro
- Rossi Norma Teresa
- Royal Adelaide Hospital
- Royal Children's Hospital Brisbane
- Royal Melbourne Hospital
- Ruhr University Bochum
- Samadder N. Jewel
- Sampson Julian R.
- Schmiegel Wolff
- Scott Rodney J.
- Secretariat
- Semmelweis University
- Senter Leigha
- Seppälä Toni
- Sheba Medical Center at Tel Hashomer
- Sheth Harsh
- Sijmons Rolf
- Sinai Health System
- Snyder Carrie
- Southey Melissa
- St. Mark's Hospital and Academic Institute
- Stakelum Aine
- Steinke-Lange Verena
- Stoffel Elena
- Sultan Zainal Abidin University
- Sunde Lone
- Tel Aviv University
- ten Broeke Sanne W.
- The Faculty of Medicine
- The Technical Faculty of IT and Design
- The University of Sydney
- Therkildsen Christina
- Thibodeau Stephen N.
- Thomas Huw
- Thorlacius-Ussing Ole
- Tibiletti Maria Grazia
- Tjandra Douglas
- Tokyo Metropolitan Komagome Hospital
- Torrezan Giovana Tardin
- TU Dresden
- Universidad del Tolima
- Universiti Sains Malaysia
- University Health Network
- University Hospital Basel
- University Hospital Bonn
- University Hospital Cologne
- University Hospital Düsseldorf
- University Hospital Zurich
- University Medical Center Groningen
- University of Bologna
- University of Bonn
- University of Hawaii at Manoa
- University of Helsinki
- University of Insubria
- University of Jyväskylä
- University of Manchester
- University of Melbourne
- University of Michigan Ann Arbor
- University of Newcastle
- University of North Carolina System
- University of Oslo
- University of Vermont
- Vaccaro Carlos Alberto
- Vainer Elez
- Valle Adriana Della
- van Hest Liselotte P.
- van Overeem Hansen Thomas
- Vangala Deepak
- Vita-Salute San Raffaele University
- von Knebel Doeberitz Magnus
- VU University Medical Center
- Wadt Karin
- Ward Robyn
- Weitz Jürgen
- Williams Heinric
- Win Aung Ko
- Winship Ingrid
- Winter Des
- Witten/Herdecke University
- Woolcock Institute of Medical Research
- Yamaguchi Tatsuro
- Zahary Mohd N.
- Zaránd Attila
- Publication venue
- Figshare
- Publication date
- 01/10/2022
- Field of study
Additional file 1
Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
- Author
- Aalborg University
- Aalborg University Hospital
- Aarhus University Hospital
- Abu-Freha Naim
- AC Camargo Hospital
- Ahadova Aysel
- Ajuntament de L’Hospitalet
- Alvarez-Valenzuela Karin
- Amor David
- Ankathil Ravindran
- Aretz Stefan
- Arizona State University
- Arnold Julie
- Aronson Melyssa
- Backman Ann-Sofie
- Barca-Tierno Verónica
- Bassaneze Thiago
- Ben-Gurion University of the Negev
- Bernstein Inge
- Bertario Lucio
- Bohorquez Mabel
- Bonanni Bernardo
- Brunet Joan
- Buchanan Daniel D.
- Burn John
- Büttner Reinhard
- Caldés Trinidad
- Capella Gabriel
- Cardiff University
- Carraro Dirce Maria
- Catholic University Of Korea St. Vincent's Hospital
- Cavestro Giulia Martina
- Center for Medical Genetics and Primary Health Care
- Central Finland Health Care District
- Central University of Venezuela
- Chen-Shtoyerman Rakefet
- Copenhagen University Hospital
- Creighton University
- Crosbie Emma J.
- da Silva Leandro Apolinário
- de Vargas Aída Falcón
- Department of Architecture Design and Media Technology
- Department of Clinical Genetics
- Department of Clinical Medicine
- Department of Electronic Systems
- Department of Gastrointestinal Surgery
- Department of Molecular Diagnostics
- Dominguez-Valentin Mev
- Dowty James G.
- Dueñas Nuria
- Duijkers Floor
- Duke NUS Graduate Medical School
- Dębniak Tadeusz
- Engel Christoph
- Esperon Patricia
- Evans Dafydd Gareth
- Figueiredo Jane
- Fox Chase Cancer Center
- Fred Hutchinson Cancer Research Center
- Gallinger Steven
- Garre Pilar
- Geisinger Medical Center
- Gerdes Anne-Marie
- Gluck Nathan
- Green Kate
- Greenblatt Marc
- Guillem Jose G.
- Guillén-Ponce Carmen
- Half Elizabeth
- Hall Michael J.
- Hampel Heather
- Haupt Saskia
- Hebrew University of Jerusalem
- Heidelberg University
- Heinimann Karl
- Helsinki University Hospital
- Heuveline Vincent
- Holinski-Feder Elke
- Hoogerbrugge Nicoline
- Hopper John L.
- Horisberger Karoline
- Hospital Clínico San Carlos
- Hospital Italiano de Buenos Aires
- Hospital Privado Centro Médico de Córdoba
- Hospital Sírio-Libanês
- Hospital Universitario Ramón y Cajal
- Hovig Eivind
- Hunter Medical Research Institute
- Hüneburg Robert
- Imperial College London
- Instituto Nacional de Cancerologia
- Instituto Nacional de Câncer
- Institutsekretariat
- IRCCS Istituto Europeo di Oncologia - Milano
- James Paul
- Jenkins Mark A.
- John Thomas
- Kalfayan Pablo
- Kariv Revital
- Karolinska Institutet
- Karolinska University Hospital
- Katz Lior
- Kennelly Rory
- Klinik Diagnostik
- Klinik Kirurgi og Kræftbehandling
- Kloor Matthias
- Kohonen-Corish Maija R. J.
- Laghi Luigi
- Laish Ido
- Lalloo Fiona
- Latchford Andrew
- Lautrup Charlotte K.
- Le Marchand Loïc
- Lee Grant
- Leiden University Medical Center
- Leipzig University
- Lepisto Anna
- Levi Zohar
- Ligtenberg Marjolijn J. L.
- Lindberg Lars Joachim
- Lindblom Annika
- Lindor Noralane
- Lino-Silva Leonardo S.
- Loeffler Markus
- Lopez-Koestner Francisco
- Lubiński Jan
- Macrae Finlay
- Maharaja Sayajirao University of Baroda
- Manchester University NHS Foundation Trust
- Martin Claudia
- Mayo Clinic Hospital
- Mayo Clinic Jacksonville FL
- Mecklin Jukka-Pekka
- Menzies School of Health Research
- Mints Miriam
- Monahan Kevin
- Monash University
- Morrison Patrick J.
- Moslein Gabriela
- Møller Pål
- Nakken Sigve
- Nascimento Ivana
- Neffa Florencia
- Newcastle University
- Newcomb Polly A.
- Newton Katie
- Ngeow Joanne
- Nielsen Maartje
- Northern Vermont University
- Ohio State University
- Okkels Henrik
- Pai Rish
- Palmero Edenir
- Parma University Hospital
- Parry Susan
- Pavicic Walter Hernán
- Peltomäki Päivi
- Perne Claudia
- Peter Maccallum Cancer Centre
- Pineda Marta
- Plazzer John-Paul
- Pomeranian Medical University in Szczecin
- Poplawski Nicola
- Portenkirchner Carmen
- Pylvänäinen Kirsi
- Queen's University Belfast
- Rabin Medical Center Israel
- Radboud University Nijmegen Medical Centre
- Rahner Nils
- Rambam Health Care Campus Israel
- Rasmussen Lene J.
- Redler Silke
- Reece Jeanette
- Renkonen-Sinisalo Laura
- Ricciardiello Luigi
- Rigshospitalet Copenhagen University Hospital
- Rosner Guy
- Rossi Benedito Mauro
- Rossi Norma Teresa
- Royal Adelaide Hospital
- Royal Children's Hospital
- Royal Melbourne Hospital
- Ruhr University Bochum
- Samadder N. Jewel
- Sampson Julian R.
- Schmiegel Wolff
- Scott Rodney J.
- Secretariat
- Semmelweis University
- Senter Leigha
- Seppälä Toni
- Sheba Medical Center at Tel Hashomer
- Sheth Harsh
- Sijmons Rolf
- Sinai Health System
- Snyder Carrie
- Southey Melissa
- St. Mark's Hospital and Academic Institute
- Stakelum Aine
- Steinke-Lange Verena
- Stoffel Elena
- Sultan Zainal Abidin University
- Sunde Lone
- Tel Aviv University
- ten Broeke Sanne W.
- The Faculty of Medicine
- The Technical Faculty of IT and Design
- The University of Sydney
- Therkildsen Christina
- Thibodeau Stephen N.
- Thomas Huw
- Thorlacius-Ussing Ole
- Tibiletti Maria Grazia
- Tjandra Douglas
- Tokyo Metropolitan Komagome Hospital
- Torrezan Giovana Tardin
- TU Dresden
- Universidad del Tolima
- Universiti Sains Islam Malaysia
- University Hospital Basel
- University Hospital Bonn
- University Hospital Cologne
- University Hospital Düsseldorf
- University Hospital Zurich
- University Medical Center Groningen
- University of Bologna
- University of Hawaii at Manoa
- University of Helsinki
- University of Insubria
- University of Jyväskylä
- University of Manchester
- University of Melbourne
- University of Michigan Ann Arbor
- University of North Carolina System
- University of Oslo
- University of Toronto
- Vaccaro Carlos Alberto
- Vainer Elez
- Valle Adriana Della
- van Hest Liselotte P.
- van Overeem Hansen Thomas
- Vangala Deepak
- Vita-Salute San Raffaele University
- von Knebel Doeberitz Magnus
- VU University Medical Center
- Wadt Karin
- Ward Robyn
- Weitz Jürgen
- Williams Heinric
- Win Aung Ko
- Winship Ingrid
- Winter Des
- Witten/Herdecke University
- Woolcock Institute of Medical Research
- Yamaguchi Tatsuro
- Zahary Mohd N.
- Zaránd Attila
- Publication venue
- Figshare
- Publication date
- 01/10/2022
- Field of study
Additional file 1
Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
- Author
- Aalborg University
- Aalborg University Hospital
- Aarhus University
- Abu-Freha Naim
- Ahadova Aysel
- Alvarez-Valenzuela Karin
- Amor David
- Ankathil Ravindran
- Aretz Stefan
- Ariel University
- Arnold Julie
- Aronson Melyssa
- Backman Ann-Sofie
- Barca-Tierno Verónica
- Bassaneze Thiago
- Belfast Health and Social Care Trust
- Bellvitge Biomedical Research Institute
- Ben-Gurion University of the Negev
- Bernstein Inge
- Bertario Lucio
- Bohorquez Mabel
- Bonanni Bernardo
- Brunet Joan
- Buchanan Daniel D.
- Burn John
- Büttner Reinhard
- Caldés Trinidad
- Capella Gabriel
- Cardiff University
- Carraro Dirce Maria
- Cavestro Giulia Martina
- Central Finland Health Care District
- Chen-Shtoyerman Rakefet
- Creighton University
- Crosbie Emma J.
- da Silva Leandro Apolinário
- de Vargas Aída Falcón
- Department of Clinical Genetics
- Department of Clinical Medicine
- Department of Gastrointestinal Surgery
- Department of Molecular Diagnostics
- Dominguez-Valentin Mev
- Dowty James G.
- Dueñas Nuria
- Duijkers Floor
- Dębniak Tadeusz
- Engel Christoph
- Esperon Patricia
- Evans Dafydd Gareth
- Figueiredo Jane
- Foundation for Research in Genetics and Endocrinology FRIGE House
- Fox Chase Cancer Center
- Fred Hutchinson Cancer Research Center
- Gallinger Steven
- Garre Pilar
- Geisinger Medical Center
- Gerdes Anne-Marie
- German Cancer Research Center
- Gluck Nathan
- Green Kate
- Greenblatt Marc
- Guillem Jose G.
- Guillén-Ponce Carmen
- Hadassah University Medical Centre
- Half Elizabeth
- Hall Michael J.
- Hampel Heather
- Haupt Saskia
- Hebrew University of Jerusalem
- Heidelberg Institute for Theoretical Studies
- Heidelberg University
- Heinimann Karl
- Heinrich Heine University Düsseldorf
- Heuveline Vincent
- Holinski-Feder Elke
- Hoogerbrugge Nicoline
- Hopper John L.
- Horisberger Karoline
- Hospital A.C. Camargo
- Hospital Central De Las Fuerzas Armadas
- Hospital Clínico San Carlos de Madrid
- Hospital de Câncer de Barretos
- Hospital Italiano de Buenos Aires
- Hospital Privado Centro Médico de Córdoba
- Hospital Ramon y Cajal
- Hospital Sirio-Libanes
- Hospital Vargas de Caracas
- Hovig Eivind
- Hunter Medical Research Institute
- Hüneburg Robert
- Imperial College London
- Institute Catala Oncologia
- Instituto Nacional de Cancerologia
- Instituto Nacional de Câncer
- IRCCS Istituto Europeo di Oncologia - Milano
- James Paul
- Jenkins Mark A.
- John Thomas
- Kalfayan Pablo
- Kariv Revital
- Karolinska Institutet
- Katz Lior
- Kennelly Rory
- Klinik Diagnostik
- Klinik Kirurgi og Kræftbehandling
- Kloor Matthias
- Kohonen-Corish Maija R. J.
- Laghi Luigi
- Laish Ido
- Lalloo Fiona
- Latchford Andrew
- Lautrup Charlotte K.
- Le Marchand Loïc
- Lee Grant
- Leiden University
- Leipzig University
- Lepisto Anna
- Levi Zohar
- Ligtenberg Marjolijn J. L.
- Lindberg Lars Joachim
- Lindblom Annika
- Lindor Noralane
- Lino-Silva Leonardo S.
- Loeffler Markus
- London North West University Healthcare NHS Trust
- Lopez-Koestner Francisco
- Lubiński Jan
- Ludwig Maximilian University of Munich
- Macrae Finlay
- Manchester University NHS Foundation Trust
- Martin Claudia
- Mayo Clinic Rochester MN
- Mayo Clinic Scottsdale AZ
- Mecklin Jukka-Pekka
- MGZ – Center of Medical Genetics
- Mints Miriam
- Monahan Kevin
- Monash University
- Morrison Patrick J.
- Moslein Gabriela
- Møller Pål
- Nakken Sigve
- Nascimento Ivana
- National Cancer Centre
- Neffa Florencia
- New Zealand Familial Gastrointestinal Cancer Service
- Newcastle University
- Newcomb Polly A.
- Newton Katie
- Ngeow Joanne
- Nielsen Maartje
- Ohio State University
- Okkels Henrik
- Pai Rish
- Palmero Edenir
- Parry Susan
- Pavicic Walter Hernán
- Peltomäki Päivi
- Perne Claudia
- Peter Maccallum Cancer Centre
- Pineda Marta
- Plazzer John-Paul
- Pomeranian Medical University in Szczecin
- Poplawski Nicola
- Portenkirchner Carmen
- Programa Cáncer Heredo Familiar Clínica Universidad de los Ande
- Pylvänäinen Kirsi
- Rabin Medical Center Israel
- Radboud University Nijmegen
- Rahner Nils
- Rambam Health Care Campus Israel
- Ramón y Cajal Health Research Institute
- Rasmussen Lene J.
- Redler Silke
- Reece Jeanette
- Renkonen-Sinisalo Laura
- Ricciardiello Luigi
- Rosner Guy
- Rossi Benedito Mauro
- Rossi Norma Teresa
- Royal Adelaide Hospital
- Royal Children's Hospital
- Royal Melbourne Hospital
- Ruhr University Bochum
- Samadder N. Jewel
- Sampson Julian R.
- Schmiegel Wolff
- Scott Rodney J.
- Semmelweis University
- Senter Leigha
- Seppälä Toni
- Sheba Medical Center at Tel Hashomer
- Sheth Harsh
- Sijmons Rolf
- Snyder Carrie
- Southey Melissa
- St. Mark's Hospital and Academic Institute
- Stakelum Aine
- Steinke-Lange Verena
- Stoffel Elena
- Sunde Lone
- Tampere University
- Technische Universität Dresden
- Tel Aviv Sourasky Medical Center
- Tel Aviv University
- ten Broeke Sanne W.
- The Faculty of Medicine
- The European Hereditary Tumour Group (EHTG) and the International Mismatch Repair Consortium (IMRC)
- Therkildsen Christina
- Thibodeau Stephen N.
- Thomas Huw
- Thorlacius-Ussing Ole
- Tibiletti Maria Grazia
- Tjandra Douglas
- Tokyo Metropolitan Komagome Hospital
- Torrezan Giovana Tardin
- Universidad Central de Venezuela
- Universidade de Pernambuco
- Universidade Federal da Bahia
- Universiti Sains Malaysia
- Universiti Sultan Zainal Abidin
- University College Dublin
- University of Adelaide
- University of Amsterdam
- University of Basel
- University of Bologna
- University of Bonn
- University of Cologne
- University of Copenhagen
- University of Groningen
- University of Hawai'i at Mānoa
- University of Helsinki
- University of Insubria
- University of Jyväskylä
- University of Manchester
- University of Melbourne
- University of Michigan Ann Arbor
- University of North Carolina at Chapel Hill
- University of Oslo
- University of Parma
- University of Sydney
- University of Tolima
- University of Toronto
- University of Vermont
- University of Zurich
- Vaccaro Carlos Alberto
- Vainer Elez
- Valle Adriana Della
- van Hest Liselotte P.
- van Overeem Hansen Thomas
- Vangala Deepak
- Vita-Salute San Raffaele University
- von Knebel Doeberitz Magnus
- Vrije Universiteit Amsterdam
- Wadt Karin
- Ward Robyn
- Weitz Jürgen
- Williams Heinric
- Win Aung Ko
- Winship Ingrid
- Winter Des
- Witten/Herdecke University
- Woolcock Institute of Medical Research
- Yamaguchi Tatsuro
- Zahary Mohd N.
- Zane Cohen Centre Sinai Health System
- Zaránd Attila
- Publication venue
- Figshare
- Publication date
- 01/01/2022
- Field of study
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This comprised confirmed and inferred path_MMR carriers who were first- or second-degree relatives of Lynch syndrome probands. Results In the PLSD, 8,153 subjects had follow-up colonoscopy surveillance for a total of 67,604 years and 578 carriers had CRC diagnosed. Average cumulative incidences of CRC in path_MLH1 carriers at 70 years of age were 52% in males and 41% in females; for path_MSH2 50% and 39%; for path_MSH6 13% and 17% and for path_PMS2 11% and 8%. In contrast, in the IMRC cohort, corresponding cumulative incidences were 40% and 27%; 34% and 23%; 16% and 8% and 7% and 6%. Comparing just the European carriers in the two series gave similar findings. Numbers in the PLSD series did not allow comparisons of carriers from other continents separately. Cumulative incidences at 25 years were < 1% in all retrospective groups. Conclusions Prospectively observed CRC incidences (PLSD) in path_MLH1 and path_MSH2 carriers undergoing colonoscopy surveillance and polypectomy were higher than in the retrospective (IMRC) series, and were not reduced in path_MSH6 carriers. These findings were the opposite to those expected. CRC point incidence before 50 years of age was reduced in path_PMS2 carriers subjected to colonoscopy, but not significantly so
Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
- Author
- Aalborg University
- Aalborg University Hospital
- Aarhus University
- Abu-Freha Naim
- Ahadova Aysel
- Alvarez-Valenzuela Karin
- Amor David
- Ankathil Ravindran
- Aretz Stefan
- Arnold Julie
- Aronson Melyssa
- Backman Ann-Sofie
- Barca-Tierno Verónica
- Bassaneze Thiago
- Belfast Health and Social Care Trust
- Bellvitge Biomedical Research Institute
- Bernstein Inge
- Bertario Lucio
- Bohorquez Mabel
- Bonanni Bernardo
- Brunet Joan
- Buchanan Daniel D.
- Burn John
- Büttner Reinhard
- Caldés Trinidad
- Capella Gabriel
- Cardiff University
- Carraro Dirce Maria
- Cavestro Giulia Martina
- Central Finland Health Care District
- Chen-Shtoyerman Rakefet
- Creighton University
- Crosbie Emma J.
- da Silva Leandro Apolinário
- de Vargas Aída Falcón
- Department of Clinical Genetics
- Department of Clinical Medicine
- Department of Gastrointestinal Surgery
- Department of Molecular Diagnostics
- Dominguez-Valentin Mev
- Dowty James G.
- Dueñas Nuria
- Duijkers Floor
- Dębniak Tadeusz
- Engel Christoph
- Esperon Patricia
- Evans Dafydd Gareth
- Figueiredo Jane
- Foundation for Research in Genetics and Endocrinology FRIGE House
- Fox Chase Cancer Center
- Fred Hutchinson Cancer Research Center
- Gallinger Steven
- Garre Pilar
- Geisinger Medical Center
- Gerdes Anne-Marie
- German Cancer Research Center
- Gluck Nathan
- Green Kate
- Greenblatt Marc
- Guillem Jose G.
- Guillén-Ponce Carmen
- Hadassah University Medical Centre
- Half Elizabeth
- Hall Michael J.
- Hampel Heather
- Haupt Saskia
- Hebrew University of Jerusalem
- Heidelberg Institute for Theoretical Studies
- Heidelberg University
- Heinimann Karl
- Heinrich Heine University Düsseldorf
- Heuveline Vincent
- Holinski-Feder Elke
- Hoogerbrugge Nicoline
- Hopper John L.
- Horisberger Karoline
- Hospital A.C. Camargo
- Hospital Central De Las Fuerzas Armadas
- Hospital Clínico San Carlos de Madrid
- Hospital de Câncer de Barretos
- Hospital Italiano de Buenos Aires
- Hospital Privado Centro Médico de Córdoba
- Hospital Ramon y Cajal
- Hospital Sirio-Libanes
- Hospital Vargas de Caracas
- Hovig Eivind
- Hüneburg Robert
- Imperial College London
- Instituto Nacional de Cancerologia
- Instituto Nacional de Câncer
- IRCCS Istituto Clinico Humanitas - Rozzano (Milano)
- IRCCS Istituto Europeo di Oncologia - Milano
- James Paul
- Jenkins Mark A.
- John Thomas
- Kalfayan Pablo
- Kaplan Medical Center Israel
- Kariv Revital
- Karolinska Institutet
- Katz Lior
- Kennelly Rory
- Klinik Diagnostik
- Klinik Kirurgi og Kræftbehandling
- Kloor Matthias
- Kohonen-Corish Maija R. J.
- Laghi Luigi
- Laish Ido
- Lalloo Fiona
- Latchford Andrew
- Lautrup Charlotte K.
- Le Marchand Loïc
- Lee Grant
- Leiden University
- Leipzig University
- Lepisto Anna
- Levi Zohar
- Ligtenberg Marjolijn J. L.
- Lindberg Lars Joachim
- Lindblom Annika
- Lindor Noralane
- Lino-Silva Leonardo S.
- Loeffler Markus
- Lopez-Koestner Francisco
- Lubiński Jan
- Ludwig Maximilian University of Munich
- Macrae Finlay
- Manchester University NHS Foundation Trust
- Martin Claudia
- Mayo Clinic Rochester MN
- Mayo Clinic Scottsdale AZ
- Mecklin Jukka-Pekka
- MGZ – Center of Medical Genetics
- Mints Miriam
- Monahan Kevin
- Monash University
- Morrison Patrick J.
- Moslein Gabriela
- Murdoch Children's Research Institute
- Møller Pål
- Nakken Sigve
- Nanyang Technological University
- Nascimento Ivana
- Neffa Florencia
- New Zealand Familial Gastrointestinal Cancer Service
- Newcastle University
- Newcomb Polly A.
- Newton Katie
- Ngeow Joanne
- Nielsen Maartje
- Ohio State University
- Okkels Henrik
- Ospedale di Circolo
- Pai Rish
- Palmero Edenir
- Parry Susan
- Pavicic Walter Hernán
- Peltomäki Päivi
- Perne Claudia
- Peter Maccallum Cancer Centre
- Pineda Marta
- Plazzer John-Paul
- Pomeranian Medical University in Szczecin
- Poplawski Nicola
- Portenkirchner Carmen
- Programa Cáncer Heredo Familiar Clínica Universidad de los Ande
- Pylvänäinen Kirsi
- Rabin Medical Center Israel
- Radboud University Nijmegen
- Rahner Nils
- Rambam Health Care Campus Israel
- Ramón y Cajal Health Research Institute
- Rasmussen Lene J.
- Redler Silke
- Reece Jeanette
- Renkonen-Sinisalo Laura
- Ricciardiello Luigi
- Rosner Guy
- Rossi Benedito Mauro
- Rossi Norma Teresa
- Royal Adelaide Hospital
- Royal Melbourne Hospital
- Ruhr University Bochum
- Samadder N. Jewel
- Sampson Julian R.
- Schmiegel Wolff
- Scott Rodney J.
- Semmelweis University
- Senter Leigha
- Seppälä Toni
- Sheba Medical Center at Tel Hashomer
- Sheth Harsh
- Sijmons Rolf
- Snyder Carrie
- Soroka Medical Center
- Southey Melissa
- St. Mark's Hospital and Academic Institute
- Stakelum Aine
- Steinke-Lange Verena
- Stoffel Elena
- Sunde Lone
- Tampere University
- Technische Universität Dresden
- Tel Aviv Sourasky Medical Center
- Tel Aviv University
- ten Broeke Sanne W.
- The Faculty of Medicine
- The European Hereditary Tumour Group (EHTG) and the International Mismatch Repair Consortium (IMRC)
- Therkildsen Christina
- Thibodeau Stephen N.
- Thomas Huw
- Thorlacius-Ussing Ole
- Tibiletti Maria Grazia
- Tjandra Douglas
- Tokyo Metropolitan Komagome Hospital
- Torrezan Giovana Tardin
- Universidad Central de Venezuela
- Universidade de Pernambuco
- Universidade Federal da Bahia
- Universiti Sains Malaysia
- Universiti Sultan Zainal Abidin
- University College Dublin
- University of Adelaide
- University of Amsterdam
- University of Barcelona
- University of Basel
- University of Bologna
- University of Bonn
- University of Cologne
- University of Copenhagen
- University of Groningen
- University of Hawai'i at Mānoa
- University of Helsinki
- University of Jyväskylä
- University of Manchester
- University of Melbourne
- University of Michigan Ann Arbor
- University of Newcastle
- University of North Carolina at Chapel Hill
- University of Oslo
- University of Sydney
- University of Tolima
- University of Toronto
- University of Vermont
- University of Zurich
- Vaccaro Carlos Alberto
- Vainer Elez
- Valle Adriana Della
- van Hest Liselotte P.
- van Overeem Hansen Thomas
- Vangala Deepak
- Vita-Salute San Raffaele University
- von Knebel Doeberitz Magnus
- Vrije Universiteit Amsterdam
- Wadt Karin
- Ward Robyn
- Weitz Jürgen
- Williams Heinric
- Win Aung Ko
- Winship Ingrid
- Winter Des
- Witten/Herdecke University
- Woolcock Institute of Medical Research
- Yamaguchi Tatsuro
- Zahary Mohd N.
- Zane Cohen Centre Sinai Health System
- Zaránd Attila
- Publication venue
- Figshare
- Publication date
- 01/01/2022
- Field of study
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This comprised confirmed and inferred path_MMR carriers who were first- or second-degree relatives of Lynch syndrome probands. Results In the PLSD, 8,153 subjects had follow-up colonoscopy surveillance for a total of 67,604 years and 578 carriers had CRC diagnosed. Average cumulative incidences of CRC in path_MLH1 carriers at 70 years of age were 52% in males and 41% in females; for path_MSH2 50% and 39%; for path_MSH6 13% and 17% and for path_PMS2 11% and 8%. In contrast, in the IMRC cohort, corresponding cumulative incidences were 40% and 27%; 34% and 23%; 16% and 8% and 7% and 6%. Comparing just the European carriers in the two series gave similar findings. Numbers in the PLSD series did not allow comparisons of carriers from other continents separately. Cumulative incidences at 25 years were < 1% in all retrospective groups. Conclusions Prospectively observed CRC incidences (PLSD) in path_MLH1 and path_MSH2 carriers undergoing colonoscopy surveillance and polypectomy were higher than in the retrospective (IMRC) series, and were not reduced in path_MSH6 carriers. These findings were the opposite to those expected. CRC point incidence before 50 years of age was reduced in path_PMS2 carriers subjected to colonoscopy, but not significantly so
Additional file 22 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Academia Sinica Institute of Biomedical Sciences
- Academy of Scientific and Innovative Research (AcSIR)
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Alexandria University
- Algebra University College
- Arbeeva Liubov
- Arctic Centre Univ. of Groningen
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Atlanta VA Health Care System
- Attia John
- Attikon University Hospital
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Barts and The London School of Medicine and Dentistry
- Bayyana Swati
- Bechayda Sonny Augustin
- Beijing Institute for Brain Disorders
- Beijing Institute of Ophthalmology
- Beijing Tongren Hospital Capital Medical University
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- BHF Glasgow Cardiovascular Research Centre Faculty of Medicine
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bispebjerg and Frederiksberg Hospital
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bornholms Hospital
- Boston University School of Public Health
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Broad Institute
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Carolina Population Center
- Case Western Reserve University
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Center for Non-Communicable Diseases
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Charité Universitätsmedizin Berlin
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Children's Hospital Oakland Research Institute
- Children's Hospital Philadelphia and University of Pennsylvania School of Medicine
- Chinese Academy of Medical Sciences &
- Chinese National Human Genome Center at Shanghai
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christian-Albrechts-Universitaet zu Kiel
- Christofidou Paraskevi
- Chuang Lee-Ming
- Churchill Hospital
- CIBIOR
- Cincinnati Children's Hospital Medical Center
- Ciullo Marina
- Clarendon Laboratory
- Clarke Shoa L.
- Clinical Trial Service Unit and Epidemiological Studies Unit
- College of Life Sciences
- College of Medicine
- Columbia University Mailman School of Public Health
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- CSIR-Centre for Cellular and Molecular Biology
- CSIR-Institute of Genomics and Integrative Biology
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Dasman Diabetes Institute
- Data Tecnica International
- Data Tecnica International
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- deCODE genetics/Amgen Inc.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Department of Clinical Neuroscience
- Department of Epidemiology and Data Science Amsterdam UMC
- Department of General Practice Amsterdam UMC
- Department of Nephrology Instituto de Investigaciones Biomédicas Sant Pau
- Dipartimento di Chimica e Farmacia Università di Sassari
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Dromokaiteio Psychiatric Hospital
- Duke-NUS Medical School Singapore
- DZHK (German Centre for Cardiovascular Research) Partner site Greifswald
- Ealing Hospital
- Elders Petra J. M.
- Emory University School of Medicine
- Engmann Jorgen
- Erasmus University Medical Center
- Erdmann Jeanette
- EURAC Research Affiliated Institute of the University of Lübeck
- Evans Michele K.
- Ewha Womans University
- Ewha Womans University School of Medicine
- Faculteit Medische Wetenschappen/UMCG
- Faculty of Life Sciences &
- Faisalabad Institute of Cardiology
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Fimlab Laboratories Department of Clinical Chemistry
- Finnish Institute for Health and Welfare
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Fred Hutchinson Cancer Research Center
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Fuwai Hospital Chinese Academy of Medical Sciences &
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Geisinger
- Genome Institute of Singapore
- George Institute for Global Health at Peking University Health Science Centre
- George Washington University
- German Center for Diabetes Research
- German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
- German Chronic Kidney Disease Study
- German Institute of Human Nutrition
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Glenfield Hospital
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graduate School of Medicine
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Hallym University
- Han Sohee
- Hansen Torben
- Harbor-UCLA Medical Center
- Harokopio University
- Hart Leen M.‘t
- Harvard Medical School
- Harvard School of Public Health
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hospital of Southern Jutland
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Icahn School of Medicine at Mount Sinai
- Icelandic Heart Association
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Imperial College
- Imperial College and Imperial Healthcare NHS Trust
- Ingelsson Erik
- Institute for Biomedicine (affiliated with the University of Lübeck)
- Institute for Maternal and Child Health - IRCCS Burlo Garofolo
- Institute of Epidemiology 2
- Institute of Molecular and Clinical Ophthalmology
- Institute of Nutrition and Functional Foods (INAF)
- Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán
- Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
- Instituto Nacional de Medicina Genómica
- InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes
- Interuniversity Cardiology Institute of The Netherlands
- IRCCS Neuromed
- Irvin Marguerite R.
- Istituto di Ricerca Genetica e Biomedica
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Jawaharlal Nehru University
- Ji Yingji
- Jichi Medical University
- Jin Zi-Bing
- John Radcliffe Hospital
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- JSS Academy of Higher Education and Research
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karolinska University Hospital
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- KfH Kidney Center Traunstein
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
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- Kim Young Jin
- King Abdulaziz University
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- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kurume University School of Medicine
- Kutalik Zoltan
- Kuusisto Johanna
- Kyoto University Graduate School of Medicine
- Kyung Hee University School of Medicine
- Kyushu University
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Laboratory for Financial Engineering of Laval University
- Lamina Claudia
- Landspitali University Hospital
- Lange Leslie A.
- Langenberg Claudia
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- Le Phuong
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- Leonard Hampton L.
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- Long Jirong
- Loos Ruth J. F.
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- Ltd
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- Lynch Julie A.
- Lyssenko Valeriya
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- Mellström Dan
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Minerva Foundation Institute for Medical Research Helsinki
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- MRC Epidemiology Unit
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- Munroe Patricia B.
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- März Winfried
- Møllehave Line T.
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- Nalls Mike A.
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- Nelson Christopher P.
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- Newcastle University Business School
- Nielsen Aneta A.
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- Niinikoski Harri
- Nikus Kjell
- Ninewells Hospital
- Nongmaithem Suraj S.
- Noordam Raymond
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- Northwestern University
- Northwestern University Feinberg School of Medicine
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- Novo Nordisk Foundation Center for Basic Metabolic Research
- Ntalla Ioanna
- Nutile Teresa
- Obura Morgan O.
- Ohio State University
- Ohlsson Claes
- Okada Yukinori
- Oklahoma City Veterans Affairs Medical Center
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- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- Osaka University Graduate School of Medicine
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- O’Donnell Christopher J.
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- Pajukanta Päivi
- Palmer Colin N. A.
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- Parra Esteban J.
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- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M.
- Pennell Craig E.
- Pennington Biomedical Research Center
- Penninx Brenda
- Pennsylvania State University
- Peters Annette
- Petersen Eva R. B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Privatpraxis Prof Jonas und Dr Panda-Jonas
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- QIMR Berghofer Medical Research Instititute
- Qu Jia
- Quantinuum Research LLC
- Queen Mary University of London
- Queen's University
- Radboud University Nijmegen
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D.C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Regeneron Genetics Center
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- RIKEN Center for Integrative Medical Sciences
- Ripatti Samuli
- Ritchie Marylyn D.
- Rollins School of Public Health
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rush University Medical Center
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sahlgrenska University Hospital
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schering-Plough
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- School of Clinical Medicine
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shanghai Institute of Nutrition and Health
- Shimane University School of Medicine
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Singapore Eye Research Institute
- Singapore Immunology Network (SIgN) Agency for Science Technology and Research Singapore, Biopolis
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Southern University of Science and Technology
- Spector Tim D.
- Spracklen Cassandra N.
- St George's University of London
- St. Olavs University Hospital
- Stanford University
- Stanford University School of Medicine
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Strangeways Research Laboratory
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Sungkyunkwan University
- Sungkyunkwan University School of Medicine
- Surakka Ida
- Swiss Institute of Bioinformatics
- Sygehus Lillebælt
- SYNLAB Medizinisches Versorgungszentrum Weiden GmbH
- Tabara Yasuharu
- Tai EShyong
- Taichung Veterans General Hospital
- Taipei Veterans General Hospital
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tampere University Hospital
- Tampereen Yliopisto
- Tang Hua
- Tardif Jean-Claude
- Technical University Munich
- Technical University of Munich
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- The Institute for Translational Genomics and Population Sciences
- The University of Newcastle
- the University of Texas Health Science
- The University of Texas Health Science Center at Houston
- The University of Tokyo
- The University of Western Australia
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tohoku University
- Tongji Medical College
- Traunstein Hospital
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turku University Hospital and University of Turku
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Universidad Adolfo Ibáñez
- Universidad de Granada
- Universidad Nacional Autónoma de México
- University Greifswald
- University Hospital of Southern Denmark
- University Medical Center Groningen
- University Medical Center Utrecht
- University Medicine Greifswald
- University of Aberdeen
- University of Alabama Birmingham
- University of Bergen
- University of Bristol
- University of California Los Angeles
- University of California San Francisco
- University of Chinese Academy of Sciences
- University of College London
- University of Colorado Denver
- University of Copenhagen
- University of Copenhagen Faculty of Health Sciences
- University of Dundee
- University of Eastern Finland
- University of Edinburgh
- University of Essen
- University of Essex
- University of Exeter
- University of Exeter Medical School
- University of Gothenburg
- University of Gothenburg Sahlgrenska Academy
- University of Groningen
- University of Groningen
- University of Heidelberg
- University of Helsinki
- University of Helsinki
- University of Houston
- University of Iceland
- University of Illinois College of Medicine
- University of Kelaniya
- University of Lausanne
- University of Leicester
- University of Lübeck
- University of Massachusetts
- University of Massachusetts Boston
- University of Melbourne
- University of Michigan
- University of Michigan Medical School
- University of Michigan School of Public Health
- University of Mississippi Medical Center
- University of Montreal
- University of Newcastle Australia
- University of North Carolina
- University of Oslo
- University of Oulu
- University of Oxford Medical Sciences Division
- University of Pennsylvania
- University of Pennsylvania Perelman School of Medicine
- University of Pittsburgh
- University of Pittsburgh Graduate School of Public Health
- University of Queensland
- University of Regensburg
- University of San Carlos
- University of Science and Technology of China
- University of South Carolina
- University of Southern Denmark
- University of Split School of Medicine
- University of Surrey
- University of Sydney
- University of Tasmania
- University of Texas Health Science Center at Houston
- University of the Witwatersrand
- University of the Witwatersrand Faculty of Health Sciences
- University of Toronto
- University of Turku
- University of Utah
- University of Virginia
- University of Washington School of Medicine
- University of Washington Seattle
- University of Zaragoza
- Universität Potsdam
- Universitätsklinikum Regensburg
- UPMC Hillman Cancer Center
- Uppsala University
- VA Boston Healthcare System
- VA Palo Alto Health Care System
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vanderbilt University Medical Center
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verve Therapeutics
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Virgen de las Nieves University Hospital
- Vitart Veronique
- Vrije Universiteit Amsterdam de Boelelaan
- VU University Medical Center
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Washington University in St. Louis
- Washington University School of Medicine in St. Louis
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weill Cornell Medicine-Qatar
- Weir David R.
- Weiss Stefan
- Wellcome Sanger Institute
- Wellcome Trust Centre for Human Genetics
- Wenzhou Medical University
- Westlake Laboratory of Life Sciences and Biomedicine
- Westlake University
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yong Loo Lin School of Medicine
- Yonsei University
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 22: Table S14. Test for difference in effects for index variants from sex-stratified meta-analysis
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