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Comparison of International Study Group Criteria and International Criteria for Behcet's Disease in the Azeri population of Iran
Introduction: Behcet's disease (BD) is a chronic systemic inflammatory
disease affecting multiple organs and systems such as mucosa, skin, eye, joints and
cardiovascular, nervous and gastrointestinal systems. Various criteria are proposed for the
assessment of BD. This study was designed to compare performance of two internationally
collaborated criteria for diagnosis of BD, namely International Study Group (ISG) criteria and
International Criteria for Behcet's Disease (ICBD) in the Azeri population of Iran. Methods:
In a descriptive analytical study, 859 consecutive patients with one of the major clinical
manifestations of BD were included. All patients were examined and evaluated by an expert
rheumatologist and diagnosis was confirmed clinically. All patients were assessed by ISG and
ICBD criteria. Finally, sensitivity, specificity, positive predictive value, negative
predictive value, and accuracy of both criteria were calculated. Results: We included 859
patients in this study. BD was diagnosed in 211 patients. Sensitivity, specificity and
accuracy of ISG criteria were 64.9%, 100%, and 91.4%, respectively. Sensitivity, specificity
and accuracy of ICBD criteria were 94.7%, 99.6% and 98.5%, respectively. Conclusion: Based on
the finding of the present study, sensitivity and accuracy of ICBD criteria for diagnosis of
BD in Azeri population are higher than ISG criteria. So we propose to use ICBD criteria for
the evaluation of patients with suspected BD to decrease the rate of missed
diagnosis