Construction of Urban Design Support System using Cloud Computing Type Virtual Reality and Case Study

This paper contributes a design support system based on cloud-computing type virtual reality (cloud-based VR) for urban planning and urban design. A platform for Cloud-based VR technology, i.e. a VR-Cloud server, is used to open a VR dataset to public collaboration over the Internet. The digital attributes representing the design scheme of design concepts includes the land use zone, building regulations, urban design style, and other design details of architectural design, landscape, and traffic/architectural environment/sunshine/wheather/noise/inundation/tsunami/earthquake/evacuati on simulation. Then practice using this cloud-based VR urban design support system is categorized into three applicable case ‘types’, synchronized, distributed synchronized and distributed non-synchronized. The effect of the use of this system in urban design and in urban planning processes is evaluated

Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role

Intestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk factors, such as age, sex, and obesity, have been proposed for the pathogenesis of OA, the underlying links between these person-level factors and OA are still enigmatic. Based on the current understanding in the crosstalk between intestinal microbiota and these risk factors, intestinal microbiota could be considered as a major hidden risk factor that provides a unifying mechanism to explain the involvement of these person-level risk factors in OA