HSIC Regularized LTSA

Hilbert-Schmidt Independence Criterion (HSIC) measures statistical independence between two random variables. However, instead of measuring the statistical independence between two random variables directly, HSIC first transforms two random variables into two Reproducing Kernel Hilbert Spaces (RKHS) respectively and then measures the kernelled random variables by using Hilbert-Schmidt (HS) operators between the two RKHS. Since HSIC was first proposed around 2005, HSIC has found wide applications in machine learning. In this paper, a HSIC regularized Local Tangent Space Alignment algorithm (HSIC-LTSA) is proposed. LTSA is a well-known dimensionality reduction algorithm for local homeomorphism preservation. In HSIC-LTSA, behind the objective function of LTSA, HSIC between high-dimensional and dimension-reduced data is added as a regularization term. The proposed HSIC-LTSA has two contributions. First, HSIC-LTSA implements local homeomorphism preservation and global statistical correlation during dimensionality reduction. Secondly, HSIC-LTSA proposes a new way to apply HSIC: HSIC is used as a regularization term to be added to other machine learning algorithms. The experimental results presented in this paper show that HSIC-LTSA can achieve better performance than the original LTSA

Structural Basis and Functional Mechanism of Lipoprotein in Cholesterol Transport

Lipoprotein transports lipids in circulation and is primary driver/modulator of atherosclerosis. Highly dynamics of lipoprotein conformations are crucial to lipid transport along the cholesterol transport pathway, where high-density lipoprotein (HDL), low-density lipoprotein (LDL) and cholesteryl ester transfer protein (CETP) are major players in lipid digestion & transport and the plasma cholesterol metabolism. This chapter covered how do HDL, LDL and CETP induce the metabolisms during cholesterol transport, and summarized recent process in the spatial information of the three lipoproteins, especially the elevations of plasma HDL and LDL, and shine a light on the assembly processes of lipoprotein particles and the substrates dynamics exchanges, for an in-depth understanding on the correlation between various lipoprotein classes and cardiovascular risk

Generation of Spatiotemporal Vortex Pulses by Simple Diffractive Grating

Spatiotemporal vortex pulses are wave packets that carry transverse orbital angular momentum, exhibiting exotic structured wavefronts that can twist through space and time. Existing methods to generate these pulses require complex setups like spatial light modulators or computer-optimized structures. Here, we demonstrate a new approach to generate spatiotemporal vortex pulses using just a simple diffractive grating. The key is constructing a phase vortex in frequency-momentum space by leveraging symmetry, resonance, and diffraction. Our approach is applicable to any wave system. We use a liquid surface wave platform to directly demonstrate and observe the real-time generation and evolution of spatiotemporal vortex pulses. This straightforward technique provides opportunities to explore pulse dynamics and potential applications across different disciplines

Qiliqiangxin Affects L Type Current in the Normal and Hypertrophied Rat Heart

Qiliqiangxin capsule is newly developed Chinese patent drug and proved to be effective and safe for the treatment of patients with chronic heart failure. We compared the effects of different dose Qiliqiangxin on L type Ca2+ current between normal and hypertrophied myocytes. A total of 40 healthy Sprague—Dawley rats were used in the study. The rats were randomly divided into two groups (control group and hypertrophy group). Cardiac hypertrophy was induced by pressure overload produced by partial ligation of the abdominal aorta. The control group was the sham-operated group. After 1 month, cardiac ventricular myocytes were isolated from the hearts of rats. Ventricular myocytes were exposed to 10 and 50 μmol/L Qiliqiangxin, and whole cell patch-clamp technique was used to study the effects of Qiliqiangxin on . The current densities of were similar in control group and in hypertrophy group . They were not statistically significant. 10 and 50 μmol/L Qiliqiangxin can decrease peak current and in control group. However, the peak current was only reduced by 50 μmol/L Qiliqiangxin in hypertrophied myocytes. The inhibited action of Qiliqiangxin on of hypertrophy group was lower than in control group. Qiliqiangxin affected L-type Ca2+ channel and blocked , as well as affected cardiac function finally. Qiliqiangxin has diphasic action that is either class IV antiarrhythmic agent or the agent of effect cardiac function

(5,5′-Dicarboxy­biphenyl-2,2′-dicarboxyl­ato-κ2 O 2,O 2′)bis­(1,10-phenanthroline-κ2 N,N′)zinc(II) dihydrate

In the title compound, [Zn(C16H8O8)(C12H8N2)2]·2H2O, the ZnII atom is located on a twofold rotation axis and is six-coordinated by two O atoms from a 5,5′-dicarboxy­biphenyl-2,2′-dicarboxyl­ate ligand and four N atoms from two 1,10-phenanthroline mol­ecules in a distorted octa­hedral geometry. The crystal structure involves O—H⋯O hydrogen bonds

(2,4-Difluoro­phen­yl)[1-(1H-1,2,4-triazol-1-yl)cyclo­prop­yl]methanone

The asymmetric unit of the title compound, C12H9F2N3O, contains two independent mol­ecules (A and B) in which the benzene and cyclo­propane rings form dihedral angles of 33.0 (1) and 29.7 (1)°, respectively. In the crystal, weak inter­molecular C—H⋯O hydrogen bonds link alternating A and B mol­ecules into chains along [010]