New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Recognizing and mitigating the negative effects of information technology use:a systematic review of persuasive characteristics in information systems

Abstract Although information systems and technology have brought many benefits into people’s everyday lives, not to mention society as a whole, they are also accompanied by negative consequences. For example, technostress, anxiety, and even different kinds of addictions are among the side effects of information technology use. Clearly, such negative consequences cannot be fully avoided, but at least some of them may be mitigated via good system design. In this study, we addressed the dark side of information technology use in everyday life and in a leisure context, reviewing contributions from the basket of eight information systems journals published between 2004 and early 2018. In our analysis, we utilized the Persuasive Systems Design model in order to recognize and analyze information system characteristics that may mitigate the negative consequences of information technology use