1,900 research outputs found
Orientational order on curved surfaces - the high temperature region
We study orientational order, subject to thermal fluctuations, on a fixed
curved surface. We derive, in particular, the average density of zeros of
Gaussian distributed vector fields on a closed Riemannian manifold. Results are
compared with the density of disclination charges obtained from a Coulomb gas
model. Our model describes the disordered state of two dimensional objects with
orientational degrees of freedom, such as vector ordering in Langmuir
monolayers and lipid bilayers above the hexatic to fluid transition.Comment: final version, 13 Pages, 2 figures, uses iopart.cl
Psychological interventions in asthma
Asthma is a multifactorial chronic respiratory disease characterised by recurrent episodes of airway obstruction. The current management of asthma focuses principally on pharmacological treatments, which have a strong evidence base underlying their use. However, in clinical practice, poor symptom control remains a common problem for patients with asthma. Living with asthma has been linked with psychological co-morbidity including anxiety, depression, panic attacks and behavioural factors such as poor adherence and suboptimal self-management. Psychological disorders have a higher-than-expected prevalence in patients with difficult-to-control asthma. As psychological considerations play an important role in the management of people with asthma, it is not surprising that many psychological therapies have been applied in the management of asthma. There are case reports which support their use as an adjunct to pharmacological therapy in selected individuals, and in some clinical trials, benefit is demonstrated, but the evidence is not consistent. When findings are quantitatively synthesised in meta-analyses, no firm conclusions are able to be drawn and no guidelines recommend psychological interventions. These inconsistencies in findings may in part be due to poor study design, the combining of results of studies using different interventions and the diversity of ways patient benefit is assessed. Despite this weak evidence base, the rationale for psychological therapies is plausible, and this therapeutic modality is appealing to both patients and their clinicians as an adjunct to conventional pharmacological treatments. What are urgently required are rigorous evaluations of psychological therapies in asthma, on a par to the quality of pharmaceutical trials. From this evidence base, we can then determine which interventions are beneficial for our patients with asthma management and more specifically which psychological therapy is best suited for each patient
On the Core of Dynamic Cooperative Games
We consider dynamic cooperative games, where the worth of coalitions varies
over time according to the history of allocations. When defining the core of a
dynamic game, we allow the possibility for coalitions to deviate at any time
and thereby to give rise to a new environment. A coalition that considers a
deviation needs to take the consequences into account because from the
deviation point on, the game is no longer played with the original set of
players. The deviating coalition becomes the new grand coalition which, in
turn, induces a new dynamic game. The stage games of the new dynamical game
depend on all previous allocation including those that have materialized from
the deviating time on.
We define three types of core solutions: fair core, stable core and credible
core. We characterize the first two in case where the instantaneous game
depends on the last allocation (rather than on the whole history of
allocations) and the third in the general case. The analysis and the results
resembles to a great extent the theory of non-cooperative dynamic games.Comment: 25 page
Vortex wandering in a forest of splayed columnar defects
We investigate the scaling properties of single flux lines in a random
pinning landscape consisting of splayed columnar defects. Such correlated
defects can be injected into Type II superconductors by inducing nuclear
fission or via direct heavy ion irradiation. The result is often very efficient
pinning of the vortices which gives, e.g., a strongly enhanced critical
current. The wandering exponent \zeta and the free energy exponent \omega of a
single flux line in such a disordered environment are obtained analytically
from scaling arguments combined with extreme-value statistics. In contrast to
the case of point disorder, where these exponents are universal, we find a
dependence of the exponents on details in the probability distribution of the
low lying energies of the columnar defects. The analytical results show
excellent agreement with numerical transfer matrix calculations in two and
three dimensions.Comment: 11 pages, 9 figure
Bridging Alone: Religious Conservatism, Marital Homogamy, and Voluntary Association Membership
This study characterizes social insularity of religiously conservative American married couples by examining patterns of voluntary associationmembership. Constructing a dataset of 3938 marital dyads from the second wave of the National Survey of Families and Households, the author investigates whether conservative religious homogamy encourages membership in religious voluntary groups and discourages membership in secular voluntary groups. Results indicate that couples’ shared affiliation with conservative denominations, paired with beliefs in biblical authority and inerrancy, increases the likelihood of religious group membership for husbands and wives and reduces the likelihood of secular group membership for wives, but not for husbands. The social insularity of conservative religious groups appears to be reinforced by homogamy—particularly by wives who share faith with husbands
Variational theory of flux-line liquids
We formulate a variational (Hartree like) description of flux line liquids
which improves on the theory we developed in an earlier paper [A.M. Ettouhami,
Phys. Rev. B 65, 134504 (2002)]. We derive, in particular, how the massive term
confining the fluctuations of flux lines varies with temperature and show that
this term vanishes at high enough temperatures where the vortices behave as
freely fluctuating elastic lines.Comment: 10 pages, 1 postscript figur
Vortex Pinning and the Non-Hermitian Mott Transition
The boson Hubbard model has been extensively studied as a model of the zero
temperature superfluid/insulator transition in Helium-4 on periodic substrates.
It can also serve as a model for vortex lines in superconductors with a
magnetic field parallel to a periodic array of columnar pins, due to a formal
analogy between the vortex lines and the statistical mechanics of quantum
bosons. When the magnetic field has a component perpendicular to the pins, this
analogy yields a non-Hermitian boson Hubbard model. At integer filling, we find
that for small transverse fields, the insulating phase is preserved, and the
transverse field is exponentially screened away from the boundaries of the
superconductor. At larger transverse fields, a ``superfluid'' phase of tilted,
entangled vortices appears. The universality class of the transition is found
to be that of vortex lines entering the Meissner phase at H_{c1}, with the
additional feature that the direction of the tilted vortices at the transition
bears a non-trivial relationship to the direction of the applied magnetic
field. The properties of the Mott Insulator and flux liquid phases with tilt
are also discussed.Comment: 20 pages, 12 figures included in text; to appear in Physical Review
Breakdown of the Mott insulator: Exact solution of an asymmetric Hubbard model
The breakdown of the Mott insulator is studied when the dissipative tunneling
into the environment is introduced to the system. By exactly solving the
one-dimensional asymmetric Hubbard model, we show how such a breakdown of the
Mott insulator occurs. As the effect of the tunneling is increased, the Hubbard
gap is monotonically decreased and finally disappears, resulting in the
insulator-metal transition. We discuss the origin of this quantum phase
transition in comparison with other non-Hermitian systems recently studied.Comment: 7 pages, revte
Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin
Background:
Griffithsin, a 121-residue protein isolated from a red algal Griffithsia sp., binds high mannose N-linked glycans of virus surface glycoproteins with extremely high affinity, a property that allows it to prevent the entry of primary isolates and laboratory strains of T- and M-tropic HIV-1. We used the sequence of a portion of griffithsin's sequence as a design template to create smaller peptides with antiviral and carbohydrate-binding properties.
Methodology/Results:
The new peptides derived from a trio of homologous β-sheet repeats that comprise the motifs responsible for its biological activity. Our most active antiviral peptide, grifonin-1 (GRFN-1), had an EC50 of 190.8±11.0 nM in in vitro TZM-bl assays and an EC50 of 546.6±66.1 nM in p24gag antigen release assays. GRFN-1 showed considerable structural plasticity, assuming different conformations in solvents that differed in polarity and hydrophobicity. Higher concentrations of GRFN-1 formed oligomers, based on intermolecular β-sheet interactions. Like its parent protein, GRFN-1 bound viral glycoproteins gp41 and gp120 via the N-linked glycans on their surface.
Conclusion:
Its substantial antiviral activity and low toxicity in vitro suggest that GRFN-1 and/or its derivatives may have therapeutic potential as topical and/or systemic agents directed against HIV-1
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