Asymmetric triplex metallohelices with high and selective activity against cancer cells

Small cationic amphiphilic α-helical peptides are emerging as agents for the treatment of cancer and infection, but they are costly and display unfavourable pharmacokinetics. Helical coordination complexes may offer a three-dimensional scaffold for the synthesis of mimetic architectures. However, the high symmetry and modest functionality of current systems offer little scope to tailor the structure to interact with specific biomolecular targets, or to create libraries for phenotypic screens. Here, we report the highly stereoselective asymmetric self-assembly of very stable, functionalized metallohelices. Their anti-parallel head-to-head-to-tail ‘triplex’ strand arrangement creates an amphipathic functional topology akin to that of the active sub-units of, for example, host-defence peptides and ​p53. The metallohelices display high, structure-dependent toxicity to the human colon carcinoma cell-line HCT116 ​p53++, causing dramatic changes in the cell cycle without DNA damage. They have lower toxicity to human breast adenocarcinoma cells (MDA-MB-468) and, most remarkably, they show no significant toxicity to the bacteria methicillin-resistant Staphylococcus aureus and Escherichia coli. At a glanc

SDSS J211852.96−073227.5: The first non-local, interacting, late-type intermediate Seyfert galaxy with relativistic jets

It has been often suggested that a tangible relation exists between relativistic jets in active galactic nuclei (AGN) and the morphology of their host galaxies. In particular, relativistic jets may commonly be related to merging events. Here we present for the first time a detailed spectroscopic and morphological analysis of a Seyfert galaxy, SDSS J211852.96−073227.5, at z = 0.26. This source has previously been classified as a gamma-ray emitting narrow-line Seyfert 1 galaxy. We re-observed it with the 6.5 m Clay Telescope and these new, high-quality spectroscopic data have revealed that it is actually an intermediate-type Seyfert galaxy. Furthermore, the results of modelling the Ks-band near-infrared images obtained with the 6.5 m Baade Telescope indicate that the AGN is hosted by a late-type galaxy in an interacting system, strengthening the suggested connection between galaxy interactions and relativistic jets

Dynamic control of chirality and self-assembly of double-stranded helicates with light

Helicity switching in biological and artificial systems is a fundamental process that allows for the dynamic control of structures and their functions. In contrast to chemical approaches to responsive behaviour in helicates, the use of light as an external stimulus offers unique opportunities to invert the chirality of helical structures in a non-invasive manner with high spatiotemporal precision. Here, we report that unidirectional rotary motors with connecting oligobipyridyl ligands, which can dynamically change their chirality upon irradiation, assemble into metal helicates that are responsive to light. The motor function controls the self-assembly process as well as the helical chirality, allowing switching between oligomers and double-stranded helicates with distinct handedness. The unidirectionality of the light-induced motion governs the sequence of programmable steps, enabling the highly regulated self-assembly of fully responsive helical structures. This discovery paves the way for the future development of new chirality-dependent photoresponsive systems including smart materials, enantioselective catalysts and light-driven molecular machines