Cystic fibrosis and acne:Does isotretinoin have a beneficial or bad effect on the lung function?

Management of cystic fibrosis (CF) has improved. This leads to adolescents asking for treatment of benign disorders like acne. Anti-inflammatory therapy is not recommend due to possible induction of resistance to antibiotics. A 23-year old male CF patient with extensive acne and scarring was effectively treated with isotretinoin, leading to longterm remission. No severe side effects or setback of pulmonary symptoms were observed. Interestingly, a positive effect of isotretinoin on pulmonary function in CF patients has been described

Cystic fibrosis and acne:Does isotretinoin have a beneficial or bad effect on the lung function?

Management of cystic fibrosis (CF) has improved. This leads to adolescents asking for treatment of benign disorders like acne. Anti-inflammatory therapy is not recommend due to possible induction of resistance to antibiotics. A 23-year old male CF patient with extensive acne and scarring was effectively treated with isotretinoin, leading to longterm remission. No severe side effects or setback of pulmonary symptoms were observed. Interestingly, a positive effect of isotretinoin on pulmonary function in CF patients has been described

Lease accounting trouble looms for corporate real estate management

Purpose – The purpose of this paper is to investigate what impact International Financial Reporting Standards (IFRS) lease accounting changes might have on corporate real estate (CRE) strategies, and what the consequences for future corporate real estate portfolio decisions might be. Design/methodology/approach – A macro-analysis based on the constructive capitalization method of Imhoff et al. (1991) is used to determine the potential impact of IFRS lease accounting changes on Amsterdam Exchange Index (AEX) listed corporations. In addition, a series of interviews were held with CRE executives to discuss this impact and with CRE and IFRS experts for general insight. Findings – The impact of IFRS lease accounting seems less severe than expected. Notwithstanding, it could form a serious bottleneck for CRE departments that do not operate on a strategic level. Therefore, IFRS lease accounting changes might act as a catalyst for the professionalization of corporate real estate management departments. Practical implications – The paper provides CRE managers with a manageable insight to alter CRE decision-making processes in relation to IFRS lease accounting. The sample size was too small to make a distinction between different industries. Originality/value – Past research showed that accounting is a potential variable in CRE decision-making, but did not yet clarify the possible impact of IFRS lease accounting on CRE strategies and the relating CRE operating decisions. Besides that, this paper also provides insight for options to cope with the (possibly severe) implication

Proposal for a Framework to Enable Elicitation of Preferences for Clients in Need of Long-Term Care

Purpose: Collaborative deliberation comprises personal engagement, recognition of alternative actions, comparative learning, preference elicitation, and preference integration. Collaborative deliberation may be improved by assisting preference elicitation during shared decision-making. This study proposes a framework for preference elicitation to facilitate collaborative deliberation in long-term care consultations. Methods: First, a literature overview was conducted comprising current models for the elicitation of preferences in health and social care settings. The models were reviewed and compared. Second, qualitative research was applied to explore those issues that matter most to clients in long-term care. Data were collected from clients in long-term care, comprising 16 interviews, 3 focus groups, 79 client records, and 200 online client reports. The qualitative analysis followed a deductive approach. The results of the literature overview and qualitative research were combined. Results: Based on the literature overview, five overarching domains of preferences were described: “Health”, “Daily life”, “Family and friends”, ”Living conditions”, and “Finances”. The credibility of these domains was confirmed by qualitative data analysis. During interviews, clients addressed issues that matter in their lives, including a “click” with their care professional, safety, contact with loved ones, and assistance with daily structure and activities. These data were used to determine the content of the domains. Conclusion: A framework for preference elicitation in long-term care is proposed. This framework could be useful for clients and professionals in preference elicitation during collaborative deliberation