Phenotypic Consequences of Copy Number Variation: Insights from Smith-Magenis and Potocki-Lupski Syndrome Mouse Models

The characterization of mice with different number of copies of the same genomic segment shows that structural changes influence the phenotypic outcome independently of gene dosage

Appareil pour l\u27\ue9tude du point de cong\ue9lation de tr\ue8s petites quantit\ue9s de liquides biologiques

Volume: 33Start Page: 128End Page: 13

An indirect examination of the function of problem behaviour associated with Fragile X Syndrome and Smith-Magenis Syndrome

Fragile X syndrome (FXS) and Smith-Magenis syndrome (SMS) are associated with a number of specific topographies of problem behavior. Very few studies have examined the function served by problem behavior in these groups. Using the Questions About Behavioral Function scale Matson and Vollmer (User’s guide: questions about behavioral function (QABF). Scientific Publishers Inc., Baton Rouge, LA, 1995) the current study examined group differences in the function of problem behavior displayed by children with FXS and SMS, in comparison to a control group of children with non-specific intellectual and developmental disabilities. Between-group analyses showed children with SMS were more likely to display problem behavior related to physical discomfort. Both within- and between-group analyses showed children with FXS were less likely to display attention-maintained problem behavior. These findings hold implications for the assessment, treatment and prevention of problem behavior associated with both FXS and SMS

Emotional Acculturation

Do emotions acculturate when people move from one culture to the next? We conceive of “emotional acculturation” as the process by which immigrants come to share the host culture’s most prevalent patterns of emotional experiences. In this chapter we will discuss the first evidence that emotional acculturation takes place, and provide details on the dynamics of this process. We will also highlight how the finding of emotional acculturation speaks to mechanisms of emotional change generally