16 research outputs found
Resolving the cadherin-F-actin connection
No full textCadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals
Apical surface supracellular mechanical properties in polarized epithelium using noninvasive acoustic force spectroscopy
No full textDesmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
No full textHistamine causes endothelial barrier disruption via Ca2+-mediated RhoA activation and tension at adherens junctions
No full textInduced cortical tension restores functional junctions in adhesion-defective carcinoma cells
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Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions
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Contact inhibition of locomotion and mechanical cross-talk between cell–cell and cell–substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates
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