Gauged U(1)U(1) Clockwork Theory

We consider the gauged $U(1)$ clockwork theory with a product of multiple gauge groups and discuss the continuum limit of the theory to a massless gauged $U(1)$ with linear dilaton background in five dimensions. The localization of the lightest state of gauge fields on a site in the theory space naturally leads to exponentially small effective couplings of external matter fields localized away from the site. We discuss the implications of our general discussion with some examples, such as mediators of dark matter interactions, flavor-changing $B$-meson decays as well as D-term SUSY breaking.Comment: 22 pages, 2 figures, Expanded discussion on dark matter mediator, To be published in Physics Letters

Softness of Supersymmetry Breaking on the Orbifold T2/Z2T^2/Z_2

We consider supersymmetry breaking due to a Scherk-Schwarz twist or localized mass terms in 6d ${\cal N}=1$ supersymmetric gauge theory compactified on the orbifold $T^2/Z_2$. We show that the Scherk-Schwarz breaking in 6d is equivalent to the localized breaking with mass terms along the lines in extra dimensions. In the presence of the considered supersymmetry breaking, we find that there arises a finite one-loop mass correction to a brane scalar due to the KK modes of bulk gauge fields.Comment: JHEP style file of 16 pages, no figures, published versio

The novel E3 ligase of PPAR?? TRIM25 regulates adipocyte differentiation

Department of Biological SciencesPeroxisome proliferator-activated receptor ?? (PPAR??) is a ligand-dependent transcription factor which regulates glucose homeostasis and adipocyte differentiation. Its transcriptional activity is regulated by not only ligands but also post-translational modifications (PTMs). In this study, we demonstrate a novel E3 ligase of PPAR??, TRIM25 directly induces ubiquitination of PPAR?? followed by proteasome-dependent degradation. During the adipocyte differentiation, both mRNA and protein expression of TRIM25 significantly decreased and negatively correlated with the expression of PPAR??. Stable expression of TRIM25 reduces PPAR?? protein levels, but not mRNA expression, and suppressed adipocyte differentiation in 3T3-L1 cells. In contrast, specific knock-down of TRIM25 increases PPAR?? protein levels and stimulates adipocyte differentiation. Furthermore, TRIM25 knock-out mouse embryonic fibroblast (MEFs) shows an increased ability for adipocyte differentiation compared with wild-type MEFs. Taken together, these data indicate that TRIM25 is a novel E3 ubiquitin ligase of PPAR??, and depict TRIM25 as a novel target for PPAR??-involved metabolic diseases.ope

Gauge Coupling Unification in a 6D SO(10) Orbifold GUT

We consider the gauge coupling running in a six-dimensional SO(10) orbifold GUT model. The bulk gauge symmetry is broken down to the standard model gauge group with an extra U(1)_X by orbifold boundary conditions and the extra U(1)_X is further broken through the U(1)_{B-L} breaking with bulk hyper multiplets. We obtain the corrections of Kaluza-Klein massive modes to the running of the gauge couplings and discuss their implication to the successful gauge coupling unification.Comment: 10 pages, 2 figures, version to appear in Physics Letters