Azimuthal correlations of forward di-hadrons in d+Au collisions at RHIC in the Color Glass Condensate

We present a good description of recent experimental data on forward di-hadron azimuthal correlations measured in deuteron-gold collisions at RHIC, where monojet production has been observed. Our approach is based on the Color Glass Condensate effective theory for the small-x degrees of freedom of the nuclear wave function, including the use of non-linear evolution equations with running QCD coupling. Our analysis provides further evidence for the presence of saturation effects in RHIC data.Comment: 4 pages, 2 figures, version to appear in PR

Scattering and radiation of water waves by permeable barriers

The two-dimensional problems of scattering and radiation of small-amplitude water waves by thin vertical porous plates in finite water depth are considered using the linear water wave theory. Applying the method of eigenfunction expansion, these boundary value problems are converted to certain dual series relations. Solutions to these relations are then obtained by a suitable application of the least squares method. For the scattering problem, four different basic configurations of the barriers are investigated, namely, ~I! a surface-piercing barrier, ~II! a bottom-standing barrier, ~III! a totally submerged barrier, and ~IV! a barrier with a gap. The performance of these types of barriers as a breakwater are examined by studying the variation of their reflection and transmission coefficients, hydrodynamic forces and moments for different values of the porous effect parameter defined by Chwang @J. Fluid Mech. 132, 395–406 ~1983!#, or the Chwang parameter. For the radiation problem, three types of wavemakers, which resemble types ~I!, ~II!, and ~III! of the above-mentioned configuration, are analyzed. The dependence of the amplitude to stroke ratio on other parameters is also investigated to study the features of these wavemakers. © 2000 American Institute of Physics.published_or_final_versio

VIDA: a virus database system for the organization of animal virus genome open reading frames

VIDA is a new virus database that organizes open reading frames (ORFs) from partial and complete genomic sequences from animal viruses. Currently VIDA includes all sequences from GenBank for Herpesviridae, Coronaviridae and Arteriviridae. The ORFs are organized into homologous protein families, which are identified on the basis of sequence similarity relationships, Conserved sequence regions of potential functional importance are identified and can be retrieved as sequence alignments. We use a controlled taxonomical and functional classification for all the proteins and protein families in the database. When available, protein structures that are related to the families have also been included. The database is available for online search and sequence information retrieval at http://www.biochem.ucl.ac.uk/bsm/virus-database/ VIDA.html

Smart Content Recognition from Images Using a Mixture of Convolutional Neural Networks

With rapid development of the Internet, web contents become huge. Most of the websites are publicly available, and anyone can access the contents from anywhere such as workplace, home and even schools. Nevertheless, not all the web contents are appropriate for all users, especially children. An example of these contents is pornography images which should be restricted to certain age group. Besides, these images are not safe for work (NSFW) in which employees should not be seen accessing such contents during work. Recently, convolutional neural networks have been successfully applied to many computer vision problems. Inspired by these successes, we propose a mixture of convolutional neural networks for adult content recognition. Unlike other works, our method is formulated on a weighted sum of multiple deep neural network models. The weights of each CNN models are expressed as a linear regression problem learned using Ordinary Least Squares (OLS). Experimental results demonstrate that the proposed model outperforms both single CNN model and the average sum of CNN models in adult content recognition.Comment: To be published in LNEE, Code: github.com/mundher/NSF

Factors influencing adolescent girls' decision in initiation for human papillomavirus vaccination: A cross-sectional study in Hong Kong

Background: Cervical cancer is one of the common cancers among women worldwide. Despite HPV vaccination being one of the effective preventive measures, it is not included in government vaccination programme in Hong Kong. This study aimed to assess the knowledge of and attitude towards cervical cancer prevention among Chinese adolescent girls in Hong Kong, and to identify factors influencing the initiation of HPV vaccination. Methods: This was a cross-sectional study conducted in Hong Kong during the period of October 2010 to November 2010. A self-administered questionnaire was used, with 1,416 girls from 8 secondary schools completing the questionnaire. Knowledge scores were composited and initiation of HPV vaccination was staged based on stage of change. Analyses were conducted to identify the association of initiation of HPV vaccination with participant's personal and family factors as well as their knowledge and attitude towards cervical cancer prevention. Results: The uptake rate of HPV vaccination was low (7%) with 58% respondents in pre-contemplation and contemplation stage. The survey identified a significant gap in knowledge on cervical cancer prevention. The main channels of information were from media and very few from schools or parents. However, 70% expressed their wishes to have more information on cancer prevention, and 78% stated that they were willing to change their lifestyles if they knew the ways of prevention. Multivariate analysis identified three independent significant factors for initiation of vaccination (action and intention): perceived cancer as terrifying disease, school should provide more information on cancer prevention, and comments from relatives and friends having received the vaccine. The cost of vaccination and socio-economic background were not found to be significant. Conclusions: Public education on cervical cancer needs to be well penetrated into the community for more sharing among friends and relatives. School as setting to provide source of information would facilitate uptake rate of HPV vaccine as students have expressed their wishes that school should provide more information on prevention of cancer. School and community education on cancer prevention would help adolescents to have better understanding of the seriousness of cancer. © 2014 Lee et al.; licensee BioMed Central Ltd.link_to_subscribed_fulltex

Engineered cementitious composites (ECC) encased concrete-steel composite stub columns under concentric compression

This paper presents an experimental investigation on the behaviour of a new form of engineered cementitious composites (ECC) encased concrete-steel composite stub columns. The proposed column section uses ECC encasement as a potential confinement layer to control the premature concrete spalling and explosive brittle failure of concrete encased steel composite columns. In this study, twelve stub columns including two bare steel and ten composite sections are tested under concentric compression. The effects of some key parameters such as material strengths, steel section type and column section configuration on the performance of proposed column sections were investigated in terms of failure behaviour, load deformation response, toughness and ductility. It was found that ECC encasement improved the compressive failure behaviour of encased composite columns and enhanced their ductility and toughness. Strain analysis was performed to trace the strain development and damage patterns of different materials. Finally, a simple equation to estimate ultimate strength of proposed columns was proposed which gave good predictions agreed well with test results

Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems

PURPOSE: In vivo, the circadian clock drives 24-h rhythms in human physiology. Isolated cells in vitro retain a functional clockwork but lack necessary timing cues resulting in the rapid loss of tissue-level circadian rhythms. This study tests the hypothesis that repeated daily mechanical stimulation acts as a timing cue for the circadian clockwork. The delineation and integration of circadian timing cues into predictive in vitro model systems, including organ-on-a-chip (OOAC) devices, represent a novel concept that introduces a key component of in vivo physiology into predictive in vitro model systems. METHODS: Quiescent bovine chondrocytes were entrained for 3 days by daily 12-h bouts of cyclic biaxial tensile strain (10%, 0.33 Hz, Flexcell) before sampling during free-running conditions. The core clock protein, BMAL-1, was quantified from normalised Western Blot signal intensity and the temporal oscillations characterised by Cosinor linear fit with 24-h period. RESULTS: Following entrainment, the cell-autonomous oscillations of the molecular clock protein, BMAL-1, exhibited circadian (24 h) periodicity (p < 0.001) which aligned to the diurnal mechanical stimuli. A 6-h phase shift in the mechanical entrainment protocol resulted in an equivalent shift of the circadian clockwork. Thus, repeated daily mechanical stimuli synchronised circadian rhythmicity of chondrocytes in vitro. CONCLUSION: This work demonstrates that daily mechanical stimulation can act as a timing cue that is sufficient to entrain the peripheral circadian clock in vitro. This discovery may be exploited to induce and sustain circadian physiology within into predictive in vitro model systems, including OOAC systems. Integration of the circadian clock within these systems will enhance their potential to accurately recapitulate human diurnal physiology and hence augment their predictive value as drug testing platforms and as realistic models of human (patho)physiology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s44164-022-00032-x

Compressive behaviour of engineered cementitious composites and concrete encased steel composite columns

This paper presents the results of an experimental study on the compressive behaviour of engineered cementitious composites and concrete encased steel (ECC-CES) composite columns. Two configurations of ECC-CES composite columns based on fully and partially concrete encasement were considered. A total of eleven short columns with different ECC and concrete encasing configurations were tested under pure compression. The effects of ECC strength, concrete strength and column configuration on the column compressive behaviour were investigated and reported in terms of failure modes, load-deformation curves, ductility and toughness. In addition, in order to study the confinement effect of different thickness ECC covers on high strength concrete (HSC), three ECC encased HSC short columns without encased steel section were also tested. The experimental results were compared with the ultimate strength predictions from different design codes for the tested columns. It was found that current design guidelines were generally conservative. Therefore, new equations with modified factors to predict the ultimate strength of ECC-CES columns were proposed. Finally, a comparison of performance of ECC-CES with conventional CES columns suggested that the ECC encasement could provide an alternative way to confine concrete core in columns applications

Compressive performance of ECC-concrete encased high strength steel composite columns

The use of high strength steel (HSS) in the construction of concrete encased steel (CES) composite columns is often limited by the strain incompatibility issue between HSS and concrete at peak-load. This study proposes an alternative approach to confine the high strength concrete with Engineered Cementitious Composite (ECC) to improve its compatibility with high strength steel. The main purpose of this study is to experimentally evaluate the axial compressive performance of the proposed composite column cross-section configuration. Behaviours of fifteen short columns including twelve ECC-CES columns are investigated in terms of failure modes, load-deformation curves, ductility and energy absorption capacity. The test parameters included ECC and concrete strengths, ECC cover thickness, steel section shape and column section's aspect ratio. It was found that ECC generally improved the failure behaviour of high strength steel CES columns and increased the deformation and energy absorption capacity. On average ECC-CES columns showed around 12% and 8% higher ductility and toughness than control concrete column, respectively. A detailed 3D nonlinear finite element model was developed and validated against experimental results. Applicability of current design codes to predict the ultimate strength of ECC-CES columns was also evaluated. Finally, a method to calculate the ECC-CES column's capacity considering effective material stresses at peak-load was proposed

Exploring the roles of FGF/MAPK and cVG1/GDF signalling on mesendoderm induction and convergent extension during chick primitive streak formation

During primitive streak formation in the chick embryo, cells undergo mesendoderm specification and convergent extension at the same time and in the same cells. Previous work has implicated cVG1 (GDF3) as a key factor for induction of primitive streak identity and positioning the primitive streak, whereas FGF signalling was implicated in regulating cell intercalation via regulation of components of the WNT-planar cell polarity (PCP) pathway. FGF has also been reported to be able to induce a primitive streak (but lacking the most axial derivatives such as notochord/prechordal mesendoderm). These signals emanate from different cell populations in the embryo, so how do they interact to ensure that the same cells undergo both cell intercalation and acquire primitive streak identity? Here we begin to address this question by examining in more detail the ability of the two classes of signals in regulating the two developmental events. Using misexpression of inducers and/or exposure to inhibitors and in situ hybridisation, we study how these two signals regulate expression of Brachyury (TBXT) and PRICKLE1 as markers for the primitive streak and the PCP, respectively. We find that both signals can induce both properties, but while FGF seems to be required for induction of the streak by cVG1, it is not necessary for induction of PRICKLE1. The results are consistent with cVG1 being a common regulator for both primitive streak identity and the initiation of convergent extension that leads to streak elongation