Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe hepatic encephalopathy

There is increasing evidence that terlipressin is useful in patients with cirrhosis and hepatorenal syndrome, but there are no data of its use in patients with acute liver failure (ALF) in whom hepatorenal syndrome is common. Although terlipressin produces systemic vasoconstriction, it produces cerebral vasodilatation and may increase cerebral blood flow (CBF). Increased CBF contributes to intracranial hypertension in patients with ALF. The aim of this study was to evaluate the safety of terlipressin in patients with ALF with respect to cerebral haemodynamics. Six successive patients with ALF were electively ventilated for grade IV hepatic encephalopathy. Patients were monitored invasively and CBF was measured (Kety- Schmidt technique). Measurements were made before, at 1, 3 hour and 5 hours after intravenous (single bolus) administration of terlipressin (0.005 mg/kg) )intravenously (single bolus), median 0.25mg (range 0.2-0.3). There was no significant change in heart rate, mean arterial pressure or cardiac output. CBF and jugular venous oxygen saturation both increased significantly at 1 hour (p<0.0=0.016) respectively. Intracranial pressure increased significantly at 21 hours (p<0=.0.031), returning back to baseline values at 42 hours. This study shows that administration of terlipressin, at a dose that did not alter systemic haemodynamicshemodynamics, resulted in worsening of cerebral hyperemia and intracranial hypertension in patients with ALF and severe hepatic encephalopathy. These data suggest the need to exercise extreme caution in the use of terlipressin in these patients in view of its potentially deleterious consequences on cerebral haemodynamics

Coulomb corrections and multiple e+e- pair production in ultra-relativistic nuclear collisions

We consider the problem of Coulomb corrections to the inclusive cross section. We show that these corrections in the limiting case of small charge number of one of the nuclei coincide with those to the exclusive cross section. Within our approach we also obtain the Coulomb corrections for the case of large charge numbers of both nuclei.Comment: 7 pages, REVTeX

Quasiclassical Green function in an external field and small-angle scattering

The quasiclassical Green functions of the Dirac and Klein-Gordon equations in the external electric field are obtained with the first correction taken into account. The relevant potential is assumed to be localized, while its spherical symmetry is not required. Using these Green functions, the corresponding wave functions are found in the approximation similar to the Furry-Sommerfeld-Maue approximation. It is shown that the quasiclassical Green function does not coincide with the Green function obtained in the eikonal approximation and has a wider region of applicability. It is illustrated by the calculation of the small-angle scattering amplitude for a charged particle and the forward photon scattering amplitude. For charged particles, the first correction to the scattering amplitude in the non-spherically symmetric potential is found. This correction is proportional to the scattering angle. The real part of the amplitude of forward photon scattering in a screened Coulomb potential is obtained.Comment: 20 pages, latex, 1 figur

Causality Problem in a Holographic Dark Energy Model

In the model of holographic dark energy, there is a notorious problem of circular reasoning between the introduction of future event horizon and the accelerating expansion of the universe. We examine the problem after dividing into two parts, the causality problem of the equation of motion and the circular logic on the use of the future event horizon. We specify and isolate the root of the problem from causal equation of motion as a boundary condition, which can be determined from the initial data of the universe. We show that there is no violation of causality if it is defined appropriately and the circular logic problem can be reduced to an initial value problem.Comment: 5 page

The mass of the b-quark from lattice NRQCD and lattice perturbation theory

We present a determination of the b-quark mass accurate through O(\alpha_s^2) in perturbation theory and including partial contributions at O(\alpha_s^3). Nonperturbative input comes from the calculation of the Upsilon and B_s energies in lattice QCD including the effect of u, d and s sea quarks. We use an improved NRQCD action for the b-quark. This is combined with the heavy quark energy shift in NRQCD determined using a mixed approach of high-beta simulation and automated lattice perturbation theory. Comparison with experiment enables the quark mass to be extracted: in the MS bar scheme we find m_b(m_b) = 4.166(43) GeV.Comment: v2 - corrected some typos and an error in the summary plo

A Survey for Planetary Nebulae in M31 Globular Clusters

We report the results of an [O III] 5007 spectroscopic survey for planetary nebulae (PNe) located within the star clusters of M31. By examining R ~ 5000 spectra taken with the WIYN+Hydra spectrograph, we identify 3 PN candidates in a sample of 274 likely globular clusters, 2 candidates in objects which may be globular clusters, and 5 candidates in a set of 85 younger systems. The possible PNe are all faint, between ~2.5 and ~6.8 mag down the PN luminosity function, and, partly as a consequence of our selection criteria, have high excitation, with [O III] 5007 to H-beta ratios ranging from 2 to ~12. We discuss the individual candidates, their likelihood of cluster membership, and the possibility that they were formed via binary interactions within the clusters. Our data are consistent with the suggestion that PN formation within globular clusters correlates with binary encounter frequency, though, due to the small numbers and large uncertainties in the candidate list, this study does not provide sufficient evidence to confirm the hypothesis.Comment: Accepted for publication in the Astrophysical Journal. 54 pages, including 9 figures and 4 table

High-energy expansion of Coulomb corrections to the e+e- photoproduction cross section

First correction to the high-energy asymptotics of the total $e^+e^-$ photoproduction cross section in the electric field of a heavy atom is derived with the exact account of this field. The consideration is based on the use of the quasiclassical electron Green function in an external electric field. The next-to-leading correction to the cross section is discussed. The influence of screening on the Coulomb corrections is examined in the leading approximation. It turns out that the high-energy asymptotics of the corresponding correction is independent of the photon energy. In the region where both produced particles are relativistic, the corrections to the high-energy asymptotics of the electron (positron) spectrum are derived. Our results for the total cross section are in good agreement with experimental data for photon energies down to a few $MeV$. In addition, the corrections to the bremsstrahlung spectrum are obtained from the corresponding results for pair production.Comment: 22 pages, 7 figures, RevTeX.Typos are corrected. The numerical results, figures and conclusions remain unchanged as they were obtained using correct formula

On the nature of Coulomb corrections to the e^+e^- pair production in ultrarelativistic heavy-ion collisions

We manifest the origin of the wrong conclusion made by several groups of authors on the absence of Coulomb corrections to the cross section of the e^+e^- pair production in ultrarelativistic heavy-ion collisions. The source of the mistake is connected with an incorrect passage to the limit in the expression for the cross section. When this error is eliminated, the Coulomb corrections do not vanish and agree with the results obtained within the Weizs\"acker-Williams approximation.Comment: 7 pages, LaTe

Strong suppression of Coulomb corrections to the cross section of e+e- pair production in ultrarelativistic nuclear collisions

The Coulomb corrections to the cross section of $e^+e^-$ pair production in ultrarelativistic nuclear collisions are calculated in the next-to-leading approximation with respect to the parameter $L=\ln \gamma_A\gamma_B$ ($\gamma_{A,B}$ are the Lorentz factors of colliding nuclei). We found considerable reduction of the Coulomb corrections even for large $\gamma_A\gamma_B$ due to the suppression of the production of $e^+e^-$ pair with the total energy of the order of a few electron masses in the rest frame of one of the nuclei. Our result explains why the deviation from the Born result were not observed in the experiment at SPS.Comment: 4 pages, RevTe