3D cell-printing of spatially graded patch for rotator cuff repair

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Development of Bioresorbable Vascular Scaffold by 3D Printing Technology for Peripheral Artery Diseas

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방사선식도염 치료를 위한 3D 프린팅 기반 바이오잉크 탑재형 식도 스텐트 개발

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Circulating Serum miRNA-205 as a Diagnostic Biomarker for Ototoxicity in Mice Treated with Aminoglycoside Antibiotics

Background: To confirm levels and detection timing of circulating microRNAs (miRNAs) in the serum of a mouse model for diagnosis of ototoxicity, circulating miR-205 in the serum was evaluated to reflect damages in the cochlear microstructure and compared to a kidney injury model. Method: A microarray for miRNAs in the serum was performed to assess the ototoxic effects of kanamycin-furosemide. Changes in the levels for the selected miRNAs (miR-205, miR-183, and miR-103) were compared in the serum and microstructures of the cochlea (stria vascularis, organ of Corti, and modiolus) between the ototoxicity and normal mouse groups. An acute kidney injury (AKI) mouse model was used to assess changes in miR-205 levels in the kidney by ototoxic drugs. Results: In the mouse model for ototoxicity, the serum levels of circulating miR-205 peaked on day 3 and were sustained from days 7–14. Furthermore, miR-205 expression was highly expressed in the organ of Corti at day 5, continued to be expressed in the modiolus at high levels until day 14, and was finally also in the stria vascularis. The serum miR-205 in the AKI mice did not change significantly compared to the normal group. Conclusions Circulating miR-205 from the cochlea, after ototoxic damage, migrates through the blood vessels to organs, which is then finally found in blood. In conditions of hearing impairment with ototoxic medications, detection of circulating miR-205 in the blood can be used to determine the extent of hearing loss. In the future, inner ear damage can be identified by simply performing a blood test before the hearing impairment due to ototoxic drugs

Development of the 3D Liver-on-a-chip using Cell-printing and its Application as a Liver Fibrosis Model

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하동헌, 이한철, 김병수, 채수훈, 심진형, 윤원수, 안근선, 조동우

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Ultrahigh strength and modulus of polyimide-carbon nanotube based carbon and graphitic fibers with superior electrical and thermal conductivities for advanced composite applications

Development of carbon fibers (CFs) with high strength and high modulus for structural applications in CF-reinforced polymer (CFRP) industry has been a challenge. Herein, we propose a method for manufacturing highly oriented polymer???carbon nanotube (CNT) composite fibers having high strength (4.8 ?? 0.2 GPa), modulus (390 ?? 48 GPa), and electrical conductivity (5.75 ?? 0.84 MS m-1) by a liquid crystalline wet-spinning process. The use of chlorosulfonic acid (CSA) as a solvent for CNTs and polyimide (PI) promotes dispersion and enables the production of high-performance composite fibers. In addition, the functional groups of PI in composite fibers improve the interfacial shear strength with epoxy resin without sizing additives by 72% compared to that of CNT fibers. Carbonization and graphitization of the composite fibers with an optimal ratio of PI (30%) and CNT cause significant improvement in their mechanical (tensile strength; 6.21 ?? 0.3 GPa and modulus; 701 ?? 47 GPa) and thermal properties (496 ?? 38 W m???1 K???1) by reducing voids and improving orientation. We believe that the polymer???CNT composites and their CFs with high strength and high modulus would be the next-generation CFs for aerospace and defense industry

Decellularized Extracellular Matrix-based Bioinks for Engineering Functional Human Tissues

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