Anatomic brain asymmetry in vervet monkeys.

Asymmetry is a prominent feature of human brains with important functional consequences. Many asymmetric traits show population bias, but little is known about the genetic and environmental sources contributing to inter-individual variance. Anatomic asymmetry has been observed in Old World monkeys, but the evidence for the direction and extent of asymmetry is equivocal and only one study has estimated the genetic contributions to inter-individual variance. In this study we characterize a range of qualitative and quantitative asymmetry measures in structural brain MRIs acquired from an extended pedigree of Old World vervet monkeys (n = 357), and implement variance component methods to estimate the proportion of trait variance attributable to genetic and environmental sources. Four of six asymmetry measures show pedigree-level bias and one of the traits has a significant heritability estimate of about 30%. We also found that environmental variables more significantly influence the width of the right compared to the left prefrontal lobe

Possible chiral phase transition in two-dimensional solid 3^3He

We study a spin system with two- and four-spin exchange interactions on the triangular lattice, which is a possible model for the nuclear magnetism of solid $^3$He layers. It is found that a novel spin structure with scalar chiral order appears if the four-spin interaction is dominant. Ground-state properties are studied using the spin-wave approximation. A phase transition concerning the scalar chirality occurs at a finite temperature, even though the dimensionality of the system is two and the interaction has isotropic spin symmetry. Critical properties of this transition are studied with Monte Carlo simulations in the classical limit.Comment: 4 pages, Revtex, 4 figures, to appear in Phys.Rev.Let

Dominant Three-Body Decays of a Heavy Higgs and Top Quark

We calculate the dominant three body Higgs decays, $H \to W^+W^-(Z^0, \gamma)$ and $H \to t\overline{t}(Z^0,\gamma ,g)$, in the Standard Model. We find that the branching ratios of these decays are of the order of few percent for large Higgs masses. We comment on the behaviour of the partial decay width $\Gamma (H \to t\overline{b}W^-)$ below the $t\overline{t}$ threshold. Numerical results of the following three body top decays, $t \to W^+b(\gamma ,g,Z^0)$ and $t \to W^+bH$, are also given. We discuss the feasibility of observing these Higgs and top decays at future high energy colliders.Comment: 19 pages (13 Figs can be sent by request), TeX, MZ-TH/92-2

Densin-180 controls the trafficking and signaling of L-type voltage-gated Ca_v 1.2 Ca^(2+) channels at excitatory synapses

Voltage-gated Ca_v1.2 and Ca_v1.3 (L-type) Ca^(2+) channels regulate neuronal excitability, synaptic plasticity, and learning and memory. Densin-180 (densin) is an excitatory synaptic protein that promotes Ca^(2+)-dependent facilitation of voltage-gated Ca_v1.3 Ca^(2+) channels in transfected cells. Mice lacking densin (densin KO) exhibit defects in synaptic plasticity, spatial memory, and increased anxiety-related behaviors --phenotypes that more closely match those in mice lacking Ca_v1.2 than Ca_v1.3. Thus, we investigated the functional impact of densin on Ca_v1.2. We report that densin is an essential regulator of Ca_v1.2 in neurons, but has distinct modulatory effects compared to its regulation of Ca_v1.3. Densin binds to the N-terminal domain of Ca_v1.2 but not Ca_v1.3, and increases Ca_v1.2 currents in transfected cells and in neurons. In transfected cells, densin accelerates the forward trafficking of Ca_v1.2 channels without affecting their endocytosis. Consistent with a role for densin in increasing the number of postsynaptic Ca_v1.2 channels, overexpression of densin increases the clustering of Ca_v1.2 in dendrites of hippocampal neurons in culture. Compared to wild-type mice, the cell-surface levels of Ca_v1.2 in the brain as well as Ca_v1.2 current density and signaling to the nucleus are reduced in neurons from densin KO mice. We conclude that densin is an essential regulator of neuronal Ca_v1 channels and ensures efficient Ca_v1.2 Ca^(2+) signaling at excitatory synapses

Near-Surface Vortex Structure in a Tornado and in a Sub-Tornado-Strength Convective-Storm Vortex Observed by a Mobile, W-Band Radar during VORTEX2

Abstract As part of the Second Verification of the Origins of Rotation in Tornadoes Experiment (VORTEX2) field campaign, a very high-resolution, mobile, W-band Doppler radar collected near-surface (≤200 m AGL) observations in an EF-0 tornado near Tribune, Kansas, on 25 May 2010 and in sub-tornado-strength vortices near Prospect Valley, Colorado, on 26 May 2010. In the Tribune case, the tornado's condensation funnel dissipated and then reformed after a 3-min gap. In the Prospect Valley case, no condensation funnel was observed, but evidence from the highest-resolution radars in the VORTEX2 fleet indicates multiple, sub-tornado-strength vortices near the surface, some with weak-echo holes accompanying Doppler velocity couplets. Using high-resolution Doppler radar data, the authors document the full life cycle of sub-tornado-strength vortex beneath a convective storm that previously produced tornadoes. The kinematic evolution of these vortices, from genesis to decay, is investigated via ground-based velocity track display (GBVTD) analysis of the W-band velocity data. It is found that the azimuthal velocities in the Tribune tornado fluctuated in concert with the (dis)appearance of the condensation funnel. However, the dynamic pressure drop associated with the retrieved azimuthal winds was not sufficient to account for the condensation funnel. In the Prospect Valley case, the strongest and longest-lived sub-tornado-strength vortex exhibited similar azimuthal velocity structure to the Tribune tornado, but had weaker azimuthal winds. In both cases, the radius of maximum azimuthal wind was inversely related to the wind speed, and changes in the axisymmetric azimuthal component of velocity were consistent with independent indicators of vortex intensification and decay

A computational model for sex-specific genetic architecture of complex traits in humans: Implications for mapping pain sensitivity

Understanding differences in the genetic architecture of complex traits between the two sexes has significant implications for evolutionary studies and clinical diagnosis. However, our knowledge about sex-specific genetic architecture is limited largely because of a lack of analytical models that can detect and quantify the effects of sex on the complexity of quantitative genetic variation. Here, we derived a statistical model for mapping DNA sequence variants that contribute to sex-specific differences in allele frequencies, linkage disequilibria, and additive and dominance genetic effects due to haplotype diversity. This model allows a genome-wide search for functional haplotypes and the estimation and test of haplotype by sex interactions and sex-specific heritability. The model, validated by simulation studies, was used to detect sex-specific functional haplotypes that encode a pain sensitivity trait in humans. The model could have important implications for mapping complex trait genes and studying the detailed genetic architecture of sex-specific differences

Perturbative Expansion around the Gaussian Effective Potential of the Fermion Field Theory

We have extended the perturbative expansion method around the Gaussian effective action to the fermionic field theory, by taking the 2-dimensional Gross-Neveu model as an example. We have computed both the zero temperature and the finite temperature effective potentials of the Gross-Neveu model up to the first perturbative correction terms, and have found that the critical temperature, at which dynamically broken symmetry is restored, is significantly improved for small value of the flavour number.Comment: 14pages, no figures, other comments Typographical errors are corrected and new references are adde