15,239 research outputs found

    Duration and breaks in sedentary behaviour: Accelerometer data from 1566 community-dwelling older men (British Regional Heart Study)

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    Background: Sedentary behaviours are increasingly recognised as raising risk of CVD events, diabetes and mortality, independently of physical activity (PA) levels. However, little is known about patterns of sedentary behaviour in older adults. Methods: Cross sectional study of 1566/3137 (50% response) men aged 71-91 years from a UK population-based cohort study. Men wore a GT3x accelerometer over the hip for one week in 2010-11. Mean daily minutes of SB, % of day in sedentary behaviours, sedentary bouts and breaks were calculated and summarized by health and demographic characteristics. Results: 1403 ambulatory men aged 78.4 years (SD 4.6 years) with ā‰„600 minutes of accelerometer wear on ā‰„3 days had complete data on covariables. Men spent on average 618 minutes (SD=83), or 72% of their day in sedentary behaviours (<100 counts/minute). On average men accumulated 72 spells of sedentary behaviours per day, with 7 breaks in each sedentary hour. Men had on average 5.1 sedentary bouts of ā‰„30 minutes, which accounted for 43% of sedentary time, and 1.4 bouts of ā‰„60 minutes, which accounted for 19% of daily sedentary time. Men who were over 80 years old, obese, depressed and had multiple chronic conditions accumulated more sedentary time and spent more time in longer sedentary bouts. Conclusions: Older men spend nearly three quarters of their day in sedentary behaviours, mostly accumulated in short bouts, although bouts lasting ā‰„30 minutes accounted for nearly half of the sedentary time each day. Men with medical risk factors were more likely to also display sedentary behaviour

    Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine.

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    In rats, FK significantly prolonged heterotopic heart graft survival over a wide dose range when given for 2 weeks starting on the day of the operation. Brief courses of FK for one to four days preoperatively, and especially beginning four days postoperatively, allowed long subsequent survival of heart grafts in otherwise untreated recipients. The seeming acceptance of the grafts with postoperative FK treatment was largely but not exclusively donor specific when tested eight days after the last FK dose by second grafts from the same donor v third-party donor grafts. FK in minimally therapeutic doses was synergistic with suboptimal doses of CyA

    The Role of Innovation in Inventory Turnover Performance

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    How a firm utilizes technological innovation to improve operations management is an important research question in today's knowledge economy but lacks empirical evidence in the literature. We use a dataset of all non-service U.S. public firms from 1976 to 2005 to examine how a firm's innovation performance is associated with its inventory turnover performance. In particular, we measure a firm's innovation performance by the ratio of its patents (either citations or counts) to its research and development (R&D) expenditure. Our fixed-effect panel regression results indicate a positive relation between innovation performance and inventory turnover ratio, and such a relation varies across industries. By differentiating process and product innovation according to patent usages, we find that process innovation has a consistent and long-lasting effect, whereas product innovation has an immediate but short-lasting effect. We also find supporting evidence for industry spillovers by showing that firms in a more innovative industry are likely to better manage their inventory performance. Our results confirm the benefit of using innovation in logistics and operations management and point to the strategic importance of integrating technology and operations management.postprin
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