Pulsar Magnetosphere : A General Relativistic Treatment

A fully general relativistic description of the pulsar magnetosphere is provided. To be more concrete, a study of the pulsar magnetosphere is performed in the context of general relativistic magnetohydrodynamics (MHD) employing the so-called Grad-Shafranov approach. Not surprisingly, the resulting Grad-Shafranov equations and all the other related general relativistic MHD equations turn out to take essentially the same structures as those for the (rotating) black hole magnetosphere. Other different natures between the two cases including the structure of singular surfaces of MHD flows in each magnetosphere are essentially encoded in the different spacetime (metric) contents. In this way, the pulsar and the black hole magnetospheres can be described in an unified fashion. Particularly, the direction of poloidal currents circulating in the neutron star magnetosphere turns out to be the same as that of currents circulating in the black hole magnetosphere which, in turn, leads to the pulsar and the black hole spin-downs via the ``magnetic braking''.Comment: 42 pages, 3 figures, Mon. Not. R. Astron. Soc.(MNRAS), in pres

The extra-embryonic area opaca plays a role in positioning the primitive streak of the early chick embryo

Classical studies have established that the marginal zone, a ring of extra-embryonic epiblast immediately surrounding the embryonic epiblast (area pellucida) of the chick embryo, is important in setting embryonic polarity by positioning the primitive streak, the site of gastrulation. The more external extra-embryonic region (area opaca) was thought to have only nutritive and support functions. Using experimental embryology approaches, this study reveals three separable functions for this outer region. First, juxtaposition of the area opaca directly onto the area pellucida induces a new marginal zone from the latter; this induced domain is entirely posterior in character. Second, ablation and grafting experiments using an isolated anterior half of the blastoderm and pieces of area opaca suggest that the area opaca can influence the polarity of the adjacent marginal zone. Finally, we show that the loss of the ability of such isolated anterior half-embryos to regulate (re-establish polarity spontaneously) at the early primitive streak stage can be rescued by replacing the area opaca by one from a younger stage. These results uncover new roles of chick extra-embryonic tissues in early development

How dsDNA breathing enhances its flexibility and instability on short length scales

We study the unexpected high flexibility of short dsDNA which recently has been reported by a number of experiments. Via the Langevin dynamics simulation of our Breathing DNA model, first we observe the formation of bubbles within the duplex and also forks at the ends, with the size distributions independent of the contour length. We find that these local denaturations at a physiological temperature, despite their rare and transient presence, can lower the persistence length drastically for a short DNA segment in agreement with experiment

Exploring the roles of FGF/MAPK and cVG1/GDF signalling on mesendoderm induction and convergent extension during chick primitive streak formation

During primitive streak formation in the chick embryo, cells undergo mesendoderm specification and convergent extension at the same time and in the same cells. Previous work has implicated cVG1 (GDF3) as a key factor for induction of primitive streak identity and positioning the primitive streak, whereas FGF signalling was implicated in regulating cell intercalation via regulation of components of the WNT-planar cell polarity (PCP) pathway. FGF has also been reported to be able to induce a primitive streak (but lacking the most axial derivatives such as notochord/prechordal mesendoderm). These signals emanate from different cell populations in the embryo, so how do they interact to ensure that the same cells undergo both cell intercalation and acquire primitive streak identity? Here we begin to address this question by examining in more detail the ability of the two classes of signals in regulating the two developmental events. Using misexpression of inducers and/or exposure to inhibitors and in situ hybridisation, we study how these two signals regulate expression of Brachyury (TBXT) and PRICKLE1 as markers for the primitive streak and the PCP, respectively. We find that both signals can induce both properties, but while FGF seems to be required for induction of the streak by cVG1, it is not necessary for induction of PRICKLE1. The results are consistent with cVG1 being a common regulator for both primitive streak identity and the initiation of convergent extension that leads to streak elongation

Open datasets in perioperative medicine: a narrative review

With the growing interest of researchers in machine learning and artificial intelligence (AI) based on large data, their roles in medical research have become increasingly prominent. Despite the proliferation of predictive models in perioperative medicine, external validation is lacking. Open datasets, defined as publicly available datasets for research, play a crucial role by providing high-quality data, facilitating collaboration, and allowing an objective evaluation of the developed models. Among the available datasets for surgical patients, VitalDB has been the most widely used, with the Medical Informatics Operating Room Vitals and Events Repository recently launched and the Informative Surgical Patient dataset for Innovative Research Environment expected to be released soon. For critically ill patients, the available resources include the Medical Information Mart for Intensive Care, the eICU Collaborative Research Database, the Amsterdam University Medical Centers Database, and the High time Resolution ICU Dataset, with the anticipated release of the Intensive Care Network with Million Patients' information for the AI Clinical decision support system Technology dataset. This review presents a detailed comparison of each to enrich our understanding of these open datasets for data science and AI research in perioperative medicine

Germline modification and engineering in avian species

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.Production of genome-edited animals using germline-competent cells and genetic modification tools has provided opportunities for investigation of biological mechanisms in various organisms. The recently reported programmed genome editing technology that can induce gene modification at a target locus in an efficient and precise manner facilitates establishment of animal models. In this regard, the demand for genome-edited avian species, which are some of the most suitable model animals due to their unique embryonic development, has also increased. Furthermore, germline chimera production through long-term culture of chicken primordial germ cells (PGCs) has facilitated research on production of genome-edited chickens. Thus, use of avian germline modification is promising for development of novel avian models for research of disease control and various biological mechanisms. Here, we discuss recent progress in genome modification technology in avian species and its applications and future strategies

Can Tax Incentives for Electronic Payments Curtail the Shadow Economy? Koreas Attempt to Reduce Underreporting in Retail Businesses

Increasing tax revenues by curtailing the shadow economy has been a central goal of tax policy and administration in the Republic of Korea since the National Tax Service was established as an independent agency in 1966. This paper examines the Tax Incentives for Electronically Traceable Payments (TIETP) introduced by the Korean tax authorities in 1999 to promote payments made using credit cards, debit cards, and electronic cash receipts in business-to-consumer transactions. TIETP allows wage and salary earners to claim tax deductions for eligible purchases made using electronically traceable payments when they file their year-end income tax return. This tax incentive scheme has greatly contributed to transforming the Korean economy into a cashless economy over the last decade and a half. Card payments as a ratio of Koreas GDP have ranked highest in the world since 2005, reaching 49% in 2014. TIETP has increased the percentage of business income earners who pay taxes from stagnant at around 30% up to the late 1990s to approximately 80% at present. The effective personal income tax rate for business income followed a continuous upward trend from 3.4% in 1998 to 6.3% in 2013. The total revenue increase driven by TIETP has been estimated as ₩3.4 trillion, with TIETP costs reaching ₩1.9 trillion. The net gain is an estimated ₩1.4 trillion (approximately US$1.3 billion), an increase of personal income tax revenue by 4.2%. TIETP also had a positive impact on income redistribution, decreasing Gini coefficients by 0.11 percentage points