The protective role of carotenoids and polyphenols in patients with head and neck cancer

AbstractHead and neck cancer is a critical global health problem and approximately 650,000 patients per year are diagnosed with this type of cancer. In addition, head and neck cancer exhibits a high recurrence rate, readily causing second primary cancers in other locations, often yielding a poor prognosis. Current medical and surgical treatment options result in considerable impairment of speaking and swallowing functions, with side effects such as nausea, vomiting, bone marrow suppression, and renal damage, thereby impairing patients' quality of life. Thus, developing a prevention and therapeutic intervention strategy for head and neck cancer is vital. Phytochemicals have been shown to have a unique ability to protect cells from damage and modulation of cell repair. The chemopreventive activities of phytochemicals have also been demonstrated to be associated with their antioxidant properties and the induction and stimulation of intercellular communication via gap junctions, which play a role in the regulation of cancer cell cycle, differentiation, apoptosis, and stagnate cancer cell growth. Phytochemicals can also regulate cancer cell signaling pathways, reduce the invasion and metastasis of cancer cells, and protect normal cells during treatment, thus reducing the damage caused by chemotherapy and radiotherapy. The most studied of the chemopreventive effects of phytochemicals are the carotenoids and phenolics. In this review, we investigated the multiple mechanisms of carotenoids and polyphenols (PPs) for use in preventing head and neck cancer, reducing the side effects of chemotherapy and radiotherapy, improving patient survival rates, and reducing the occurrence rate of second primary cancers

Cloning and characterization of MADS-box gene in oil palm

Oil palm has emerged as one of the most important source of oils and fats. The mechanism of floral organs development in this plant is still at its infancy. We describe here the cloning and characterization of a MADS-box gene in oil palm (Elaeis guineensis Jacq.) named EMADS1. It belongs to the AGAMOUS-like2 family of MADS-box gene which plays critical role in flower development as defined by the ABCDE model. EMADS1 was ubiquitously expressed in the immature male and female flower buds and its expression pattern was similar to EgAGL2 and EgMADS8 of oil palm. The EMADS1 transcript also accumulated in embryos of developing seeds. These results suggested that EMADS1 is likely to function at the initial stages of flowering in determination of the inflorescence and the identity of the flower whorls and also embryo development in seeds

The role of financial inclusion in achieving financerelated sustainable development goals (SDGs): a cross-country analysis

Financial inclusion is critical for the achievement of the Sustainable Development Goals (SDGs). Therefore, as there is a lack of extant studies linking financial inclusion to the SDGs, this present study used a panel regression model to examine the individual and combined effects of financial inclusion on the SDGs in selected countries between 2017 to 2020. As most extant studies have only examined specific SDGs individually, this present study is the first to examine the correlation between financial inclusion and finance-related Sustainable Development Goals (SDGs). The findings indicate that financial inclusion positively correlates to the 2nd, 5th, and 8th SDGs but not significantly enough to the 1st, 3rd, 9th, and 10th SDGs. A significant and positive correlation was also identified between financial inclusion and sustainable development in its entirety (finance-related SDG index). As financial inclusion may not directly affect all the SDGs, the uniqueness of this present study is that it examines seven finance-related aspects of SDGs, as outlined by the World Bank. The findings could encourage policymakers to increase efforts to raise the extent of financial inclusion to enhance the finance-related SDGs

Did the S.A.R.S. epidemic weaken the integration of Asian stock markets? Evidence from smooth time-varying cointegration analysis

The purpose of this study is to examine the effect of the Severe Acute Respiratory Syndrome (S.A.R.S.) epidemic on the long-run relationship between China and four Asian stock markets. To this end, we first employ the advanced smooth time-varying cointegration model to investigate the existence of a time-varying cointegration relation among these markets and then employ the difference-indifferences approach to analyse whether or not the S.A.R.S. epidemic impacted the long-run relation between China and these four markets during the period 1998–2008, covering 5 years before and after the S.A.R.S. outbreak. Our results support the existence of a time-varying cointegration relation in the aggregate stock price indices, and that the S.A.R.S. epidemic did weaken the long-run relationship between China and the four markets. Therefore, stockholders and policy makers should be concerned about the influence of catastrophic epidemic diseases on the financial integration of stock market in Asia

Logic-based Temporal Inferences in Natural Language

This paper concerns temporal inferences in natural language. The concept of time is crucially important because of its highly frequent use in utterances. However, time can appear in numerous forms, for example, tense or time adverbials. It also may be implicitly specified by other events associating with some temporal conjunctions, such as when, before, after, etc. A logic-based approach is adopted to represent temporal information. Situations and time adverbials can be formally represented. Lexical knowledge about time and implications of situations also expressed in terms of logical clauses. Then we propose a temporal reasoning model. Various basic types of questions such as "When did event X happen?", "How long did event X last for?", "Did event X happen at time expression T?", etc. can be interpreted into temporal queries. Finally, we also use the same framework of logic to evaluate temporal queries, carry out computation and do the further deduction

Theorizing the Role of Sport in State-Politics

If ever there was a perfect marriage, one would be hard pressed to find a more compatible couple than sport and politics. State intervention in sport has been evidenced in many countries throughout history. Today, sport and politics are still inextricabl

Mixed Reality Human Media for Social and Physical Interaction

Abstract: This paper outlines new facilities within ubiquitous human media spaces supporting embodied interaction between humans and computation both socially and physically. We believe that the current approach to developing electronic based design environments is lacking with regard to support for multi-person multi-modal design interactions. In this paper, we present an alternative ubiquitous computing environment based on an integrated design of real and virtual worlds. We implement three different research prototype systems: the Virtual Kyoto Garden, Touchy Internet, and the Human Pacman. The functional capabilities implemented in these systems include spatially-aware 3D navigation, tangible interaction, and ubiquitous human media spaces. Some of its details, benefits, and issues regarding design support are discussed

Second-trimester Maternal Serum Quadruple Test for Down Syndrome Screening: A Taiwanese Population-based Study

SummaryObjectiveTo assess the usefulness of quadruple test screening for Down syndrome in Taiwan.Materials and MethodsMaternal serum concentrations of a-fetoprotein, human chorionic gonadotropin, unconjugated estriol, and inhibin A were measured in 21,481 pregnant women from 15 to 20 weeks of gestation.ResultsOf the 21,481 women, 977 returned values greater than the high-risk cut-off value (1 in 270). Most of these women (86.2%) decided to have an invasive procedure for genetic diagnosis. Nine cases of Down syndrome and 19 cases of other chromosomal anomalies were detected prenatally. Two children with Down syndrome were diagnosed after delivery even though a low estimated risk was determined following the quadruple test. The detection rate was 81.8% (nine out of 11 cases), with a 4.4% false-positive rate. The median multiple of the median value for a-fetoprotein, human chorionic gonadotropin, unconjugated estriol and inhibin A were 0.87, 2.34, 0.77 and 2.16, respectively, in affected cases.ConclusionThis is the first study of the quadruple test for Down syndrome in a Chinese population. Our findings suggested that the second-trimester quadruple test provides an effective screening tool for Down syndrome in Taiwan