Chemical Evolution in VeLLOs

A new type of object called "Very Low Luminosity Objects (VeLLOs)" has been discovered by the Spitzer Space Telescope. VeLLOs might be substellar objects forming by accretion. However, some VeLLOs are associated with strong outflows, indicating the previous existence of massive accretion. The thermal history, which significantly affects the chemistry, between substellar objects with a continuous low accretion rate and objects in a quiescent phase after massive accretion (outburst) must be greatly different. In this study, the chemical evolution has been calculated in an episodic accretion model to show that CO and N2H+ have a relation different from starless cores or Class 0/I objects. Furthermore, the CO2 ice feature at 15.2 micron will be a good tracer of the thermal process in VeLLOs.Comment: corrected e-mail addres

Integrated genomic and transcriptomic analyses of radiation-induced malignancies

Cancer is a genetic disease caused by an unregulated expansion of a clone of cells (Sompayrac, 2004). The genetic abnormalities in cancer are the consequences of defective DNA replication, repair, maintenance, and modification, genetic background, and exposure to mutagens (Alexandrov et al., 2013). Ionizing radiation (IR), a mutagen exposed to cancer patients during clinical radiotherapy (RT), can cause DNA damage, genomic instability, and mutagenesis (Sherborne et al., 2015). While RT has been effective in treating cancer, it increases the risk of second malignant neoplasm (SMN), a severe delayed complication associated with mainly pediatric cancer survivors many decades after the treatment of their first cancer (Robison & Hudson, 2014). As the mortality of patients with childhood cancer has been decreasing, cases of radiation-induced cancers has been increasing (Robison & Hudson, 2014). The considerable contribution by RT to SMN risk illustrate the need to characterize the genetic mechanism directly responsible for radiation-induced malignancies. To better our understanding of the mutational landscape of SMNs, our specific aims are to identify potential driver mutations implicated in radiation-induced malignancies through genome and transcriptome analysis and to assess whether genetic background, specifically germline polymorphisms and mutations in tumor suppressor gene TP53, has an impact on the formation of secondary malignancies

An endomorphism of the Khovanov invariant

We construct an endomorphism of the Khovanov invariant to prove H-thinness and pairing phenomena of the invariants for alternating links. As a consequence, it follows that the Khovanov invariant of an oriented nonsplit alternating link is determined by its Jones polynomial, signature, and the linking numbers of its components.Comment: To appear in Adv. Math.; Brief summary of Khovanov invariant (math.QA/9908171) and previous result of the author (math.GT/0201105) adde

Radio Imaging of the NGC 1333 IRAS 4B Region

The NGC 1333 IRAS 4B region was observed in the 6.9 mm and 1.3 cm continuum with an angular resolution of about 0.4 arcseconds. IRAS 4BI was detected in both bands, and BII was detected in the 6.9 mm continuum only. The 1.3 cm source of BI seems to be a disk-like flattened structure with a size of about 50 AU. IRAS 4BI does not show any sign of multiplicity. Examinations of archival infrared images show that the dominating emission feature in this region is a bright peak in the southern outflow driven by BI, corresponding to the molecular hydrogen emission source HL 9a. Both BI and BII are undetectable in the mid-IR bands. The upper limit on the far-IR flux of IRAS 4BII suggests that it may be a very low luminosity young stellar object.Comment: To appear in the JKA