Gating of memory encoding of time-delayed cross-frequency MEG networks revealed by graph filtration based on persistent homology

To explain gating of memory encoding, magnetoencephalography (MEG) was analyzed over multi-regional network of negative correlations between alpha band power during cue (cue-alpha) and gamma band power during item presentation (item-gamma) in Remember (R) and No-remember (NR) condition. Persistent homology with graph filtration on alpha-gamma correlation disclosed topological invariants to explain memory gating. Instruction compliance (R-hits minus NR-hits) was significantly related to negative coupling between the left superior occipital (cue-alpha) and the left dorsolateral superior frontal gyri (item-gamma) on permutation test, where the coupling was stronger in R than NR. In good memory performers (R-hits minus false alarm), the coupling was stronger in R than NR between the right posterior cingulate (cue-alpha) and the left fusiform gyri (item-gamma). Gating of memory encoding was dictated by inter-regional negative alpha-gamma coupling. Our graph filtration over MEG network revealed these inter-regional time-delayed cross-frequency connectivity serve gating of memory encoding

Large-scale filamentary structures around the Virgo cluster revisited

We revisit the filamentary structures of galaxies around the Virgo cluster, exploiting a larger dataset based on the HyperLeda database than previous studies. In particular, this includes a large number of low-luminosity galaxies, resulting in better sampled individual structures. We confirm seven known structures in the distance range 4~$h^{-1}$~Mpc~$<$ SGY~$<$ 16~$h^{-1}$ Mpc, now identified as filaments, where SGY is the axis of the supergalactic coordinate system roughly along the line of sight. The Hubble diagram of the filament galaxies suggests they are infalling toward the main-body of the Virgo cluster. We propose that the collinear distribution of giant elliptical galaxies along the fundamental axis of the Virgo cluster is smoothly connected to two of these filaments (Leo~II~A and B). Behind the Virgo cluster (16~$h^{-1}$~Mpc~$<$ SGY~$<$ 27~$h^{-1}$~Mpc), we also identify a new filament elongated toward the NGC 5353/4 group ("NGC 5353/4 filament") and confirm a sheet that includes galaxies from the W and M clouds of the Virgo cluster ("W-M sheet"). In the Hubble diagram, the NGC 5353/4 filament galaxies show infall toward the NGC 5353/4 group, whereas the W-M sheet galaxies do not show hints of gravitational influence from the Virgo cluster. The filamentary structures identified can now be used to better understand the generic role of filaments in the build-up of galaxy clusters at z~$\approx$~0.Comment: 8 pages, 4 figures, accepted for publication in Ap

The discovery of blue-cored dwarf early-type galaxies in isolated environments

The presence of blue-cored dwarf early-type galaxies (dE(bc)s) in high-density environments supports the scenario of the transformation of infalling late-type galaxies into quiescent dwarf early-type galaxies by environmental effects. While low-density environments lacking environmental processes could not be relevant to the formation of dE(bc)s, we discovered a large sample of rare dE(bc)s in isolated environments at z < 0.01 using the NASA-Sloan Atlas catalog. Thirty-two isolated dE(bc)s were identified by visual inspection of the Sloan Digital Sky Survey images and g - r color profiles. We found that (1) isolated dE(bc)s exhibit similar structural parameters to dE(bc)s in the Virgo cluster; (2) based on the ultraviolet-r color-magnitude relation, color gradients, and optical emission lines of dE(bc)s, isolated dE(bc)s show more vigorous, centrally concentrated SF compared to their counterparts in the Virgo cluster; (3) at a given stellar mass, isolated dE(bc)s tend to have a larger fraction of gas mass than their Virgo counterparts. We discuss a scenario of episodic SF sustained by gas accretion, suggested by Sanchez Almeida et al., in which the star-bursting blue compact dwarf galaxy (BCD)-quiescent BCD (QBCD) cycle can be repeated during the Hubble time. We suggest that, in this cadence, isolated dE(bc)s might be QBCDs at pre- or post-BCD stages. Our results imply that dE(bc)s comprise a mixture of objects with two types of origins, nature or nurture, depending on their environment.Comment: 8 pages, 5 figures, accepted for publication in Astrophysical Journa

Nutrigenomic Functions of PPARs in Obesogenic Environments

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that mediate the effects of several nutrients or drugs through transcriptional regulation of their target genes in obesogenic environments.This review consists of three parts. First, we summarize current knowledge regarding the role of PPARs in governing the development of white and brown/beige adipocytes from uncommitted progenitor cells. Next, we discuss the interactions of dietary bioactive molecules, such as fatty acids and phytochemicals, with PPARs for the modulation of PPAR-dependent transcriptional activities and metabolic consequences. Lastly, the effects of PPAR polymorphism on obesity and metabolic outcomes are discussed. In this review, we aim to highlight the critical role of PPARs in the modulation of adiposity and subsequent metabolic adaptation in response to dietary challenges and genetic modifications. Understanding the changes in obesogenic environments as a consequence of PPARs/nutrient interactions may help expand the field of individualized nutrition to prevent obesity and obesity-associated metabolic comorbidities