430 research outputs found
Preserving Both Privacy and Utility in Network Trace Anonymization
As network security monitoring grows more sophisticated, there is an
increasing need for outsourcing such tasks to third-party analysts. However,
organizations are usually reluctant to share their network traces due to
privacy concerns over sensitive information, e.g., network and system
configuration, which may potentially be exploited for attacks. In cases where
data owners are convinced to share their network traces, the data are typically
subjected to certain anonymization techniques, e.g., CryptoPAn, which replaces
real IP addresses with prefix-preserving pseudonyms. However, most such
techniques either are vulnerable to adversaries with prior knowledge about some
network flows in the traces, or require heavy data sanitization or
perturbation, both of which may result in a significant loss of data utility.
In this paper, we aim to preserve both privacy and utility through shifting the
trade-off from between privacy and utility to between privacy and computational
cost. The key idea is for the analysts to generate and analyze multiple
anonymized views of the original network traces; those views are designed to be
sufficiently indistinguishable even to adversaries armed with prior knowledge,
which preserves the privacy, whereas one of the views will yield true analysis
results privately retrieved by the data owner, which preserves the utility. We
present the general approach and instantiate it based on CryptoPAn. We formally
analyze the privacy of our solution and experimentally evaluate it using real
network traces provided by a major ISP. The results show that our approach can
significantly reduce the level of information leakage (e.g., less than 1\% of
the information leaked by CryptoPAn) with comparable utility
Feedback Control of the National Airspace System
This paper proposes a general modeling framework adapted to the feedback control of traffic flows in Eulerian
models of the National Airspace System. It is shown that the problems of scheduling and routing aircraft flows in the
National Airspace System can be posed as the control of a network of queues with load-dependent service rates. Focus
can then shift to developing techniques to ensure that the aircraft queues in each airspace sector, which are an
indicator of the air traffic controller workloads, are kept small. This paper uses the proposed framework to develop
control laws that help prepare the National Airspace System for fast recovery from a weather event, given a
probabilistic forecast of capacities. In particular, the model includes the management of airport arrivals and
departures subject to runway capacity constraints, which are highly sensitive to weather disruptions.National Science Foundation (U.S.) (Contract ECCS-0745237)United States. National Aeronautics and Space Administration (Contract NNA06CN24A
Microfluidic systems for the analysis of the viscoelastic fluid flow phenomena in porous media
In this study, two microfluidic devices are proposed as simplified 1-D microfluidic analogues of a porous medium. The objectives are twofold: firstly to assess the usefulness of the microchannels to mimic the porous medium in a controlled and simplified manner, and secondly to obtain a better insight about the flow characteristics of viscoelastic fluids flowing through a packed bed. For these purposes, flow visualizations and pressure drop measurements are conducted with Newtonian and viscoelastic fluids. The 1-D microfluidic analogues of porous medium consisted of microchannels with a sequence of contractions/ expansions disposed in symmetric and asymmetric arrangements. The real porous medium is in reality, a complex combination of the two arrangements of particles simulated with the microchannels, which can be considered as limiting ideal configurations. The results show that both configurations are able to mimic well the pressure drop variation with flow rate for Newtonian fluids. However, due to the intrinsic differences in the deformation rate profiles associated with each microgeometry, the symmetric configuration is more suitable for studying the flow of viscoelastic fluids at low De values, while the asymmetric configuration provides better results at high De values. In this way, both microgeometries seem to be complementary and could be interesting tools to obtain a better insight about the flow of viscoelastic fluids through a porous medium. Such model systems could be very interesting to use in polymer-flood processes for enhanced oil recovery, for instance, as a tool for selecting the most suitable viscoelastic fluid to be used in a specific formation. The selection of the fluid properties of a detergent for cleaning oil contaminated soil, sand, and in general, any porous material, is another possible application
Robotic Wireless Sensor Networks
In this chapter, we present a literature survey of an emerging, cutting-edge,
and multi-disciplinary field of research at the intersection of Robotics and
Wireless Sensor Networks (WSN) which we refer to as Robotic Wireless Sensor
Networks (RWSN). We define a RWSN as an autonomous networked multi-robot system
that aims to achieve certain sensing goals while meeting and maintaining
certain communication performance requirements, through cooperative control,
learning and adaptation. While both of the component areas, i.e., Robotics and
WSN, are very well-known and well-explored, there exist a whole set of new
opportunities and research directions at the intersection of these two fields
which are relatively or even completely unexplored. One such example would be
the use of a set of robotic routers to set up a temporary communication path
between a sender and a receiver that uses the controlled mobility to the
advantage of packet routing. We find that there exist only a limited number of
articles to be directly categorized as RWSN related works whereas there exist a
range of articles in the robotics and the WSN literature that are also relevant
to this new field of research. To connect the dots, we first identify the core
problems and research trends related to RWSN such as connectivity,
localization, routing, and robust flow of information. Next, we classify the
existing research on RWSN as well as the relevant state-of-the-arts from
robotics and WSN community according to the problems and trends identified in
the first step. Lastly, we analyze what is missing in the existing literature,
and identify topics that require more research attention in the future
The Lyman Alpha Forest in the Spectra of QSOs
Observations of redshifted Lyman alpha forest absorption in the spectra of
quasistellar objects (QSOs) provide a highly sensitive probe of the
distribution of gaseous matter in the universe. Over the past two decades
optical spectroscopy with large ground-based telescopes, and more recently
ultraviolet spectroscopy from space have yielded a wealth of information on
what appears to be a gaseous, photoionized intergalactic medium, partly
enriched by the products of stellar nucleosynthesis, residing in coherent
structures over many hundreds of kiloparsecs. Recent progress with cosmological
hydro-simulations based on hierarchical structure formation models has led to
important insights into the physical structures giving rise to the forest. If
these ideas are correct, a truely inter- and proto-galactic medium [at high
redshift (z ~ 3), the main repository of baryons] collapses under the influence
of dark matter gravity into flattened or filamentary structures, which are seen
in absorption against background QSOs. With decreasing redshift, galaxies
forming in the denser regions, may contribute an increasing part of the Lyman
alpha absorption cross-section. Comparisons between large data samples from the
new generation of telescopes and artificial Lyman alpha forest spectra from
cosmological simulations promise to become a useful cosmological tool.Comment: latex plus three postscript figures, uses psfig,sty; Annual Review of
Astronomy and Astrophysics 1998, vol. 36 (in press
Privileged Structures and Polypharmacology within and between Protein Families.
Polypharmacology is often a key contributor to the efficacy of a drug, but is also a potential risk. We investigated two hits discovered via a cell-based phenotypic screen, the CDK9 inhibitor CCT250006 (1) and the pirin ligand CCT245232 (2), to establish methodology to elucidate their secondary protein targets. Using computational pocket-based analysis, we discovered intrafamily polypharmacology for our kinase inhibitor, despite little overall sequence identity. The interfamily polypharmacology of 2 with B-Raf was used to discover a novel pirin ligand from a very small but privileged compound library despite no apparent ligand or binding site similarity. Our data demonstrates that in areas of drug discovery where intrafamily polypharmacology is often an issue, ligand dissimilarity cannot necessarily be used to assume different off-target profiles and that understanding interfamily polypharmacology will be important in the future to reduce the risk of idiopathic toxicity and in the design of screening libraries
Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes
Non-healing chronic ulcers are a serious complication of diabetes and are a major healthcare problem. While a host of treatments have been explored to heal or prevent these ulcers from forming, these treatments have not been found to be consistently effective in clinical trials. An understanding of the changes in gene expression in the skin of diabetic patients may provide insight into the processes and mechanisms that precede the formation of non-healing ulcers. In this study, we investigated genome wide changes in gene expression in skin between patients with type 2 diabetes and non-diabetic patients using next generation sequencing. We compared the gene expression in skin samples taken from 27 patients (13 with type 2 diabetes and 14 non-diabetic). This information may be useful in identifying the causal factors and potential therapeutic targets for the prevention and treatment of diabetic related diseases
Acute phase response in two consecutive experimentally induced E. coli intramammary infections in dairy cows
<p>Abstract</p> <p>Background</p> <p>Acute phase proteins haptoglobin (Hp), serum amyloid A (SAA) and lipopolysaccharide binding protein (LBP) have suggested to be suitable inflammatory markers for bovine mastitis. The aim of the study was to investigate acute phase markers along with clinical parameters in two consecutive intramammary challenges with <it>Escherichia coli </it>and to evaluate the possible carry-over effect when same animals are used in an experimental model.</p> <p>Methods</p> <p>Mastitis was induced with a dose of 1500 cfu of <it>E. coli </it>in one quarter of six cows and inoculation repeated in another quarter after an interval of 14 days. Concentrations of acute phase proteins haptoglobin (Hp), serum amyloid A (SAA) and lipopolysaccharide binding protein (LBP) were determined in serum and milk.</p> <p>Results</p> <p>In both challenges all cows became infected and developed clinical mastitis within 12 hours of inoculation. Clinical disease and acute phase response was generally milder in the second challenge. Concentrations of SAA in milk started to increase 12 hours after inoculation and peaked at 60 hours after the first challenge and at 44 hours after the second challenge. Concentrations of SAA in serum increased more slowly and peaked at the same times as in milk; concentrations in serum were about one third of those in milk. Hp started to increase in milk similarly and peaked at 36–44 hours. In serum, the concentration of Hp peaked at 60–68 hours and was twice as high as in milk. LBP concentrations in milk and serum started to increase after 12 hours and peaked at 36 hours, being higher in milk. The concentrations of acute phase proteins in serum and milk in the <it>E. coli </it>infection model were much higher than those recorded in experiments using Gram-positive pathogens, indicating the severe inflammation induced by <it>E. coli</it>.</p> <p>Conclusion</p> <p>Acute phase proteins would be useful parameters as mastitis indicators and to assess the severity of mastitis. If repeated experimental intramammary induction of the same animals with <it>E. coli </it>is used in cross-over studies, the interval between challenges should be longer than 2 weeks, due to the carry-over effect from the first infection.</p
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