Evaluation of matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) for the Identification of Group B Streptococcus.

Objective Group B Streptococcus (GBS) is a leading cause of neonatal meningitis and sepsis worldwide. Intrapartum antibiotics given to women carrying GBS are an effective means of reducing disease in the first week of life. Rapid and reliable tests are needed to accurately identify GBS from these women for timely intrapartum antibiotic administration to prevent neonatal disease. Many laboratories now use matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) by direct plating or cell lysis for the identification of GBS isolates. The cell lysis step increases time to results for clinical samples and is more complex to perform. Therefore, we seek to evaluate the sensitivity and specificity of the quicker and more rapid direct plating method in identifying GBS. Results We directly compared swab isolates analysed by both direct plating and cell lysis method and demonstrated that direct plating has a sensitivity and specificity of 0.97 and 1, respectively, compared to an additional cell lysis step. We demonstrated that MALDI-TOF MS can be successfully used for batch processing by the direct plating method which saves time. These results are reassuring for laboratories worldwide who seek to identify GBS from swabs samples as quickly as possible

Improved Noisy Student Training for Automatic Speech Recognition

Recently, a semi-supervised learning method known as "noisy student training" has been shown to improve image classification performance of deep networks significantly. Noisy student training is an iterative self-training method that leverages augmentation to improve network performance. In this work, we adapt and improve noisy student training for automatic speech recognition, employing (adaptive) SpecAugment as the augmentation method. We find effective methods to filter, balance and augment the data generated in between self-training iterations. By doing so, we are able to obtain word error rates (WERs) 4.2%/8.6% on the clean/noisy LibriSpeech test sets by only using the clean 100h subset of LibriSpeech as the supervised set and the rest (860h) as the unlabeled set. Furthermore, we are able to achieve WERs 1.7%/3.4% on the clean/noisy LibriSpeech test sets by using the unlab-60k subset of LibriLight as the unlabeled set for LibriSpeech 960h. We are thus able to improve upon the previous state-of-the-art clean/noisy test WERs achieved on LibriSpeech 100h (4.74%/12.20%) and LibriSpeech (1.9%/4.1%).Comment: 5 pages, 5 figures, 4 tables; v2: minor revisions, reference adde

Solving Linux Upgradeability Problems Using Boolean Optimization

Managing the software complexity of package-based systems can be regarded as one of the main challenges in software architectures. Upgrades are required on a short time basis and systems are expected to be reliable and consistent after that. For each package in the system, a set of dependencies and a set of conflicts have to be taken into account. Although this problem is computationally hard to solve, efficient tools are required. In the best scenario, the solutions provided should also be optimal in order to better fulfill users requirements and expectations. This paper describes two different tools, both based on Boolean satisfiability (SAT), for solving Linux upgradeability problems. The problem instances used in the evaluation of these tools were mainly obtained from real environments, and are subject to two different lexicographic optimization criteria. The developed tools can provide optimal solutions for many of the instances, but a few challenges remain. Moreover, it is our understanding that this problem has many similarities with other configuration problems, and therefore the same techniques can be used in other domains.Comment: In Proceedings LoCoCo 2010, arXiv:1007.083

Towards micro-arcsecond spatial resolution with Air Cherenkov Telescope arrays as optical intensity interferometers

In this poster contribution we highlight the equivalence between an Imaging Air Cherenkov Telescope (IACT) array and an Intensity Interferometer for a range of technical requirements. We touch on the differences between a Michelson and an Intensity Interferometer and give a brief overview of the current IACT arrays, their upgrades and next generation concepts (CTA, AGIS, completion 2015). The latter are foreseen to include 30-90 telescopes that will provide 400-4000 different baselines that range in length between 50m and a kilometre. Intensity interferometry with such arrays of telescopes attains 50 micro-arcseconds resolution for a limiting V magnitude of ~8.5. This technique opens the possibility of a wide range of studies, amongst others, probing the stellar surface activity and the dynamic AU scale circumstellar environment of stars in various crucial evolutionary stages. Here we discuss possibilities for using IACT arrays as optical Intensity Interferometers.Comment: Appeared in the proceedings of "The Universe under the Microscope - Astrophysics at High Angular Resolution", Journal of Physics:Conference Series (IOP; http://www.iop.org/EJ/toc/1742-6596/131/1

The Effects of Information Literacy Instruction on Business Students’ Job Readiness

The purpose of this study is to examine college student perceptions of information literacy instruction and to what extent library instruction influences students’ attitudes in their business research during their job-readiness training through the Panthers Advanced Career Experience (PACE). The findings suggest that library instruction intervention positively influenced and increased confidence in completing the information research for their client-based consultation project

Bolla Bollana boulder beds:A Neoproterozoic trough mouth fan in South Australia?

The Bolla Bollana Formation is an exceptionally thick (ca 1500 m), rift-related sedimentary succession cropping out in the northern Flinders Ranges, South Australia, which was deposited during the Sturtian (mid Cryogenian) glaciation. Lithofacies analysis reveals three distinct facies associations which chart changing depositional styles on an ice-sourced subaqueous fan system. The diamictite facies association is dominant, and comprises both massive and stratified varieties with a range of clast compositions and textures, arranged into thick beds (1 to 20 m), representing stacked, ice-proximal glaciogenic debris-flow deposits. A channel belt facies association, most commonly consisting of normally graded conglomerates and sandstones, displays scour and fill structure of ca 10 m width and 1 to 3 m depth: these strata are interpreted as channelized turbidites. Rare mud-filled channels in this facies association bear glacially striated lonestones. Finally, a sheet heterolithics facies association contains a range of conglomerates through sandstones to silty shales arranged into clear, normally graded cycles from the lamina to bed scale. These record a variety of non-channelized turbidites, probably occupying distal and/or inter-channel locations on the subaqueous fan. Coarsening and thickening-up cycles, capped by dolomicrites or mudstones, are indicative of lobe build out and abandonment, potentially as a result of ice lobe advance and stagnation. Dropstones, recognized by downwarped and punctured laminae beneath pebbles to boulders in shale, or in delicate climbing ripple cross-laminated siltstones, are clearly indicative of ice rafting. The co-occurrence of ice-rafted debris and striated lonestones strongly supports a glaciogenic sediment source for the diamictites. Comparison to Pleistocene analogues enables an interpretation as a trough mouth fan, most probably deposited leeward of a palaeo-ice stream. Beyond emphasizing the highly dynamic nature of Sturtian ice sheets, these interpretations testify to the oldest trough mouth fan recorded to date.Daniel P. Le Heron, Marie E. Busfield, and Alan S. Collin

CO J=2-1 line emission in cluster galaxies at z~1: fueling star formation in dense environments

We present observations of CO J=2-1 line emission in infrared-luminous cluster galaxies at z~1 using the IRAM Plateau de Bure Interferometer. Our two primary targets are optically faint, dust-obscured galaxies (DOGs) found to lie within 2 Mpc of the centers of two massive (>10^14 Msun) galaxy clusters. CO line emission is not detected in either DOG. We calculate 3-sigma upper limits to the CO J=2-1 line luminosities, L'_CO < 6.08x10^9 and < 6.63x10^9 K km/s pc^2. Assuming a CO-to-H_2 conversion factor derived for ultraluminous infrared galaxies in the local Universe, this translates to limits on the cold molecular gas mass of M_H_2 < 4.86x10^9 Msun and M_H_2 < 5.30x10^9 Msun. Both DOGs exhibit mid-infrared continuum emission that follows a power-law, suggesting that an AGN contributes to the dust heating. As such, estimates of the star formation efficiencies in these DOGs are uncertain. A third cluster member with an infrared luminosity, L_IR < 7.4x10^11 Lsun, is serendipitously detected in CO J=2-1 line emission in the field of one of the DOGs located roughly two virial radii away from the cluster center. The optical spectrum of this object suggests that it is likely an obscured AGN, and the measured CO line luminosity is L'_CO = (1.94 +/- 0.35)x10^10 K km/s pc^2, which leads to an estimated cold molecular gas mass M_H_2 = (1.55+/-0.28)x10^10 Msun. A significant reservoir of molecular gas in a z~1 galaxy located away from the cluster center demonstrates that the fuel can exist to drive an increase in star-formation and AGN activity at the outskirts of high-redshift clusters.Comment: 22 pages, 4 figures; accepted for publication in Ap