Islamophobia: An American Conundrum Spurred By Donald Trump’s Executive Order and Political Rhetoric

The negative rhetoric directed toward Muslims in the United States has largely been focused on Muslim refugees because it allows for a connotation that a radical group is entering the United States.https://ecommons.udayton.edu/roesch_symposium_content/1032/thumbnail.jp

Quantifying the latitudinal representivity of in situ solar wind observations

Advanced space-weather forecasting relies on the ability to accurately predict near-Earth solar wind conditions. For this purpose, physics-based, global numerical models of the solar wind are initialized with photospheric magnetic field and coronagraph observations, but no further observation constraints are imposed between the upper corona and Earth orbit. Data assimilation (DA) of the available in situ solar wind observations into the models could potentially provide additional constraints, improving solar wind reconstructions, and forecasts. However, in order to effectively combine the model and observations, it is necessary to quantify the error introduced by assuming point measurements are representative of the model state. In particular, the range of heliographic latitudes over which in situ solar wind speed measurements are representative is of primary importance, but particularly difficult to assess from observations alone. In this study we use 40+ years of observation-driven solar wind model results to assess two related properties: the latitudinal representivity error introduced by assuming the solar wind speed measured at a given latitude is the same as that at the heliographic equator, and the range of latitudes over which a solar wind measurement should influence the model state, referred to as the observational localisation. These values are quantified for future use in solar wind DA schemes as a function of solar cycle phase, measurement latitude, and error tolerance. In general, we find that in situ solar wind speed measurements near the ecliptic plane at solar minimum are extremely localised, being similar over only 1° or 2° of latitude. In the uniform polar fast wind above approximately 40° latitude at solar minimum, the latitudinal representivity error drops. At solar maximum, the increased variability of the solar wind speed at high latitudes means that the latitudinal representivity error increases at the poles, though becomes greater in the ecliptic, as long as moderate speed errors can be tolerated. The heliospheric magnetic field and solar wind density and temperature show very similar behaviour

MicroRNA regulation of bovine monocyte inflammatory and metabolic networks in an in vivo infection model.

peer-reviewedBovine mastitis is an inflammation-driven disease of the bovine mammary gland that costs the global dairy industry several billion dollars per annum. Because disease susceptibility is a multi-factorial complex phenotype, an integrative biology approach is required to dissect the molecular networks involved. Here, we report such an approach, using next generation sequencing combined with advanced network and pathway biology methods to simultaneously profile mRNA and miRNA expression at multiple time-points (0, 12, 24, 36 and 48h) in both milk and blood FACS-isolated CD14+ monocytes from animals infected in vivo with Streptococcus uberis. More than 3,700 differentially expressed (DE) genes were identified in milk-isolated monocytes (MIMs), a key immune cell recruited to the site of infection during mastitis. Up-regulated genes were significantly enriched for inflammatory pathways, while down-regulated genes were enriched for non-glycolytic metabolic pathways. Monocyte transcriptional changes in the blood, however, were more subtle but highlighted the impact of this infection systemically. Genes up-regulated in blood-isolated-monocytes (BIMs) showed a significant association with interferon and chemokine signalling. Furthermore, twenty-six miRNAs were differentially expressed in MIMs and three in BIMs. Pathway analysis revealed that predicted targets of down-regulated miRNAs were highly enriched for roles in innate immunity (FDR < 3.4E-8) in particular TLR signalling, while up-regulated miRNAs preferentially targeted genes involved in metabolism. We conclude that during S. uberis infection miRNAs are key amplifiers of monocyte inflammatory response networks and repressors of several metabolic pathways.This study was funded in part by Teagasc RMIS 6018 and United States Department of Agriculture ARS funding 3625-32000-102-00. NL is supported by a Teagasc Walsh Fellowship

Frontal and Sagittal Plane Lower Extremity Mechanics during Single-Limb Squatting in Chronic Ankle Instability

Background/Purpose: Chronic ankle instability is a common sequelae to the lateral ankle sprain. Individuals with CAI have a higher risk of developing osteoarthritis and reporting lower quality of life scores. Biomechanical variations have been observed in individuals with CAI during ambulation and landing. To the authors’ knowledge there are no studies investigating the biomechanical profile of the SLS in individuals with CAI. The purpose of this study was to compare the biomechanics of the SLS in individuals with unilateral CAI. We hypothesized that inter-limb biomechanical differences would be observed in individuals with unilateral CAI. Methods: Participants were recruited from a university setting and provided informed consent. Individuals were included if they reported a history of at least 1 ankle sprain \u3e3 months prior to participation and scored \u3e10/37 on the Identification of Functional Ankle Instability scale. Participants were excluded if they had an ankle sprain within the last 3 months, had a history of LE surgery, or had any current LE or spinal injury. Weight-bearing dorsiflexion ROM was assessed bilaterally using established methods. Participants performed the SLS with their stance limb on the force plate, arms crossed, and their non-stance limb knee flexed to 90 degrees with their thigh vertical. A trial was 3 continuous repetitions to maximum depth at a speed of 60 bpm to a metronome. Five SLS trials were collected bilaterally. Variables of interest included peak hip, knee, and ankle sagittal and frontal plane joint angles and internal moments, as well as peak vertical ground reaction force. Results: There was approximately 3 degrees less in WB DF ROM (p=0.050) and peak DF angle on the involved limb (p=0.010). The peak plantarflexion moment was approximately 13% less (p=0.008). Conclusion: Individuals with CAI demonstrated reduced ankle DF during both clinical ROM assessment and motion analysis of SLS. Frontal plane mechanics did not differ between limbs. Clinical Relevance: The clinical assessment of WB DF coincided with reduced DF mechanics during the SLS. These data suggest that interventions to increase DF ROM may improve SLS symmetry. Clinicians can use WB DF as an assessment to assist in identifying ROM deficits that may be related to motion analysis abnormalities.https://ecommons.udayton.edu/dpt_symposium/1008/thumbnail.jp

Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome : An ICON-1 sub-study

Background: Cardiovascular disease is the leading cause of mortality for females globally, yet females are underrepresented in studies of acute coronary syndrome (ACS). Studies investigating sex-related differences in clinical outcomes of patients with non-ST elevation ACS (NSTEACS) have reported divergent results, and it is unknown whether long-term outcomes for older people with NSTEACS differ between males and females. Methods: The multi-centre prospective cohort study, ICON-1, consisted of patients aged ≥75 years undergoing coronary angiography following NSTEACS. The primary composite endpoint was all-cause mortality, myocardial infarction, unplanned revascularisation, stroke, and bleeding. We report outcomes at five-years by sex. Results: Of 264 patients, 102 (38.6%) females and 162 (61.4%) males completed the five-year follow-up and were included in the analytic cohort. At admission, females were older than males (82 ± 4.3 years vs 80.0 ± 4.1 years p = 0.018). Co-morbidity profile and GRACE score were similar between the groups. There were no differences in the provision of invasive or pharmacological treatments between sexes. At five-years, there were no association between sex and the primary outcome. Conclusion: In older adults with invasive treatment of NSTEACS, provision of guideline-indicated care and long-term clinical outcomes were similar between males and females