Correlation Between Eosinophilia and Nasal Features in Allergic Rhinosinusitis: A Pilot Study

A characteristic feature of nasal allergy is local accumulation of inflammatory cells, particularly mast cells and eosinophils, and their mediators, which have been implicated to be responsible for symptoms and signs of allergies. This prospective study tested the hypothesis that severity of nasal symptoms at presentation was related to the presence of nasal eosinophilia, using consecutive patients with allergic rhinitis attending the outpatient Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria, between March and December 2008. Excluded were those who had commenced antihistamine and similar antiallergy drugs. Nasal eosinophilia, skin sensitivity, sinus radiograph, and clinical features were graded using standard classification. The study was composed of 49 subjects (28 males and 21 females). The subjects’ age ranged from 7 to 53 years (mean ± SD: 28 ± 4 years). Nasal eosinophilia and abnormal skin sensitivity response were seen in 41 (83.8%) and 37 (75.5%) subjects, respectively. Rhinorrhoea, sneezing, and nasal obstruction constituted 42 (85.7%), 31 (63.3%), and 21 (42.9%), respectively, while inferior turbinate enlargement and radiological involvement were seen in 29 (59.2%) and 36 (73.5%) patients. The Spearman correlation test revealed a significant association between nasal smear eosinophilia and rhinorrhoea (P = .008) and sneezing (P = .04), although there was no significant association with other variables. The authors conclude that the degree of nasal eosinophilia may be useful in predicting the severity of rhinorrhoea and sneezing among the clinical features of nasal allergy

High-velocity projectile impact induced 9R phase in ultrafine-grained aluminium

Aluminium typically deforms via full dislocations due to its high stacking fault energy. Twinning in aluminium, although difficult, may occur at low temperature and high strain rate. However, the 9R phase rarely occurs in aluminium simply because of its giant stacking fault energy. Here, by using a laser-induced projectile impact testing technique, we discover a deformation-induced 9R phase with tens of nm in width in ultrafine-grained aluminium with an average grain size of 140 nm, as confirmed by extensive post-impact microscopy analyses. The stability of the 9R phase is related to the existence of sessile Frank loops. Molecular dynamics simulations reveal the formation mechanisms of the 9R phase in aluminium. This study sheds lights on a deformation mechanism in metals with high stacking fault energies

Attenuation of hyperglycemia-associated dyslipidemic, oxidative, cognitive, and inflammatory crises via modulation of neuronal ChEs/NF-κB/COX-2/NOx, and hepatorenal functional deficits by the Tridax procumbens extract

Tridax procumbens (cotton buttons) is a flowering plant with a medicinal reputation for treating infections, wounds, diabetes, and liver and kidney diseases. The present research was conducted to evaluate the possible protective effects of the T. procumbens methanolic extract (TPME) on an experimentally induced type 2 diabetes rat model. Wistar rats with streptozotocin (STZ)-induced diabetes were randomly allocated into five groups of five animals each, viz., a normal glycemic group (I), diabetic rats receiving distilled water group (II), diabetic rats with 150 (III) and 300 mg/kg of TPME (IV) groups, and diabetic rats with 100 mg/kg metformin group (V). All treatments were administered for 21 consecutive days through oral gavage. Results: Administration of the T. procumbens extract to diabetic rats significantly restored alterations in levels of fasting blood glucose (FBG), body weight loss, serum and pancreatic insulin levels, and pancreatic histology. Furthermore, T. procumbens significantly attenuated the dyslipidemia (increased cholesterol, low-density lipoprotein-cholesterol (LDL-C), triglycerides, and high-density lipoprotein (HDL) in diabetic rats), serum biochemical alterations (alanine transaminase (ALT), aspartate transaminase (AST), alanine phosphatase (ALP), blood urea nitrogen (BUN), creatinine, uric acid, and urea) and full blood count distortion in rats with STZ-induced diabetes. The TPME also improved the antioxidant status as evidenced by increased superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and decreased malondialdehyde (MDA); and decreased levels of cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)), and proinflammatory mediators including nuclear factor (NF)-κB, cyclooxygenase (COX)− 2, and nitrogen oxide (NOx) in the brain of rats with STZ-induced diabetes compared to rats with STZ-induced diabetes that received distilled water. However, TPME treatment failed to attenuate the elevated monoamine oxidases and decreased dopamine levels in the brain of rats with STZ-induced diabetes. Extract characterization by liquid chromatography mass spectrometry (LC-MS) identified isorhamnetin (retention time (RT)= 3.69 min, 8.8%), bixin (RT: 25.06 min, 4.72%), and lupeol (RT: 25.25 min, 2.88%) as the three most abundant bioactive compounds that could be responsible for the bioactivity of the plant. In conclusion, the TPME can be considered a promising alternative therapeutic option for managing diabetic complications owing to its antidiabetic, antihyperlipidemic, antioxidant, and anti-inflammatory effects in rats with STZ-prompted diabetes