Characterising activity and diet compositions for dementia prevention: protocol for the ACTIVate prospective longitudinal cohort study

Introduction Approximately 40% of late-life dementia may be prevented by addressing modifiable risk factors, including physical activity and diet. Yet, it is currently unknown how multiple lifestyle factors interact to influence cognition. The ACTIVate Study aims to (1) explore associations between 24-hour time-use and diet compositions with changes in cognition and brain function; and (2) identify duration of time-use behaviours and the dietary compositions to optimise cognition and brain function.Methods and analysis This 3-year prospective longitudinal cohort study will recruit 448 adults aged 60-70 years across Adelaide and Newcastle, Australia. Time-use data will be collected through wrist-worn activity monitors and the Multimedia Activity Recall for Children and Adults. Dietary intake will be assessed using the Australian Eating Survey food frequency questionnaire. The primary outcome will be cognitive function, assessed using the Addenbrooke's Cognitive Examination-III. Secondary outcomes include structural and functional brain measures using MRI, cerebral arterial pulse measured with diffuse optical tomography, neuroplasticity using simultaneous transcranial magnetic stimulation and electroencephalography, and electrophysiological markers of cognitive control using event-related potential and time frequency analyses. Compositional data analysis, testing for interactions between time point and compositions, will assess longitudinal associations between dependent (cognition, brain function) and independent (time-use and diet compositions) variables. Conclusions The ACTIVate Study will be the first to examine associations between time-use and diet compositions, cognition and brain function. Our findings will inform new avenues for multidomain interventions that may more effectively account for the co-dependence between activity and diet behaviours for dementia prevention. Ethics and dissemination Ethics approval has been obtained from the University of South Australia's Human Research Ethics committee (202639). Findings will be disseminated through peer-reviewed manuscripts, conference presentations, targeted media releases and community engagement events. Trial registration number >Australia New Zealand Clinical Trials Registry (ACTRN12619001659190).Ashleigh E Smith, Alexandra T Wade, Timothy Olds, Dorothea Dumuid, Michael J Breakspear, Kate Laver ... et al

Policy competition in the 2002 French legislative and presidential elections

The French two-round system of presidential elections forces candidates to choose strategies designed to maximize their votes in two different, potentially conflicting strategic contexts: a first round contest between many candidates, and a second round between (typically) a left- and a right-oriented candidate. Following a constitutional change in 2000, furthermore, presidential elections are synchronized with legislative elections, more tightly linking presidential candidates to the policy platforms of the parties they represent. This article examines the consequences of policy positioning by presidential candidates, measuring, comparing and assessing positioning in the legislative elections and in the first and second presidential election rounds. The measures come from an expert survey taken in 2002, from content analysis of party manifestos and presidential speeches, and from the 2002 French National Election Survey. The findings provide hard empirical confirmation of two commonly perceived propositions: first, that Jospin's first-round loss resulted from strategic error in moving too close to the policy centre, and second, that Chirac's won an overwhelming second-round victory because he collected all of the voters from candidates eliminated in the first round

Dimensions and alignments in European Union politics: cognitive constraints and partisan responses

As the European Union (EU) has evolved, the study agenda has shifted from 'European integration' to 'EU politics'. Missing from this new agenda, however, is an understanding of the 'cognitive constraints' on actors and how actors respond, i.e. the shape of the EU 'political space' and the location of social groups and competition between actors within this space. The article develops a theoretical framework for understanding the shape of the EU political space (the interaction between an Integration–Independence and Left–Right dimension and the location of class and sectoral groups within this map), and tests this framework on the policy positions of the Socialist, Christian Democrat and Liberal party leaders between 1976 and 1994 (using the techniques of the ECPR Party Manifestos Group Project). The research finds that the two dimensions were salient across the whole period, explains why the party families converged on pro–European positions by the 1990s and discovers the emergence of a triangular 'core' of EU politics