Un château et des chevaux : sauvegarde et valorisation du patrimoine écrit du haras de Pompadour

There is an exceptional literary heritage at the national stud farm of Pompadour and Nicole de Blomac, who is a historian and specialist in horses, was well aware of it. So she stepped up initiatives among the directors of stud farms as well as the directorate of national and regional Archives in order to save this heritage from dispersal or deterioration. The authors give here an account of the itinerary of the old archives collection of the estate of Pompadour, from the checking step taken by a young paleographer in 2000 to the pioneering process of handing this collection over to the Archives and sorting it out, and eventually, its promotion through the publication of a digital directory and academic pieces of work

Subcutaneous ivermectin as a safe salvage therapy in Strongyloides stercoralis hyperinfection syndrome : A case report

International audienceStrongyloides stercoralis hyperinfection syndrome due to the acceleration of the autoinfective cycle of the nematode is a life-threatening form of the infection occurring in immunocompromised hosts. Intestinal ileus, which is commonly encountered in this form, may reduce the bioavailability and thus the efficacy of oral anthelminthic drugs used in the treatment of the S. stercoralis hyperinfection syndrome. We report the efficacy and safety of subcutaneous administration of ivermectin in a patient infected with human T cell lymphotropic virus type I with S. stercoralis hyperinfection syndrome who was unresponsive to an oral combination of ivermectin and albendazole

In vitro susceptibility testing of Candida and Aspergillus spp. to voriconazole and other antifungal agents using Etest ® : results of a French multicentre study

International audienceMinimum inhibitory concentrations (MICs) of the antifungal agent voriconazole were determined using the Etest(R) and compared with those of amphotericin B. itraconazole and fluconazole using 1986 clinical isolates of Candida spp. Voriconazole MICs were also compared with those of amphotericin B and itraconazole using 391 clinical isolates of Aspergillus spp. Voriconazole was found to have more potent activity and lower MIC values than amphotericin B, itraconazole and fluconazole against C. albicans, C. tropicalis, C. parapsilosis and C. kefyr. Against C. glabrata and C. krusei, voriconazole was more active than either of the other two azole antifungals but had similar activity to amphotericin B. For species of Aspergillus, MIC values of voriconazole were lower than those of amphotericin B and itraconazole against A. fumigatus and A. flavus, and were similar to those of amphotericin B against A. niger. Against A. terreus, MIC values for voriconazole and itraconazole were similar. A. terreus is known to be resistant to amphotericin B, and this was reflected in higher MIC values compared with those of voriconazole and itraconazole. Voriconazole therefore compares very favourably with other antifungal agents against a large number of clinical isolates of Candida and Aspergillus spp