8 research outputs found
Efficacy and safety of faecal microbiota transplantation in patients with psoriatic arthritis:protocol for a 6-month, double-blind, randomised, placebo-controlled trial
A Study Life under Pressure - The Performance Culture amongst Danish University Students
Small Intestinal Permeability and Metabolomic Profiles in Feces and Plasma Associate With Clinical Response in Patients With Active Psoriatic Arthritis Participating in a Fecal Microbiota Transplantation Trial: Exploratory Findings From the FLORA Trial
Objective We investigated intestinal permeability and fecal, plasma, and urine metabolomic profiles in methotrexateâtreated active psoriatic arthritis (PsA) and how this related to clinical response following one sham or fecal microbiota transplantation (FMT). Methods This exploratory study is based on the FLORA trial cohort, in which 31 patients with moderateâtoâhigh peripheral PsA disease activity, despite at least 3 months of methotrexateâtreatment, were included in a 26âweek, doubleâblind, 1:1 randomized, shamâcontrolled trial. Participants were randomly allocated to receive either one healthy donor FMT (n = 15) or sham (n = 16) via gastroscopy. The primary trial end point was the proportion of treatment failures through 26âweeks. We performed a lactuloseâtoâmannitol ratio (LMR) test at baseline (n = 31) and at week 26 (n = 26) to assess small intestinal permeability. Metabolomic profiles in fecal, plasma, and urine samples collected at baseline, weeks 4, 12, and 26 were measured using 1H Nuclear Magnetic Resonance. Results Trial failures (n = 7) had significantly higher LMR compared with responders (n = 19) at week 26 (0.027 [0.017â0.33]) vs. 0.012 [0â0.064], P =â0.013), indicating increased intestinal permeability. Multivariate analysis revealed a significant model for responders (n = 19) versus failures (n = 12) at all time points based on their fecal (P <â0.0001) and plasma (P =â0.005) metabolomic profiles, whereas urine metabolomic profiles did not differ between groups (P =â1). Fecal Nâacetyl glycoprotein GlycA correlated with Health Assessment Questionnaire Disability Index (coefficient = 0.50; P =â0.03) and fecal propionate correlated with American College of Rheumatology 20 response at week 26 (coefficient = 27, P =â0.02). Conclusion Intestinal permeability and fecal and plasma metabolomic profiles of patients with PsA were associated with the primary clinical trial end point, failure versus responder