Gene duplication in bovine brain myelin proteolipid and homology with related proteins

AbstractAnalysis of the amino acid sequence of bovine brain myelin proteolipid reveals not only extensive internal homology, but also homology with portions of the myelin basic protein, the peripheral nerve myelin protein, Po, and with the small proteolipid subunit of mitochondrial ATP synthase. These results suggest that the myelin proteolipid gene has been constructed from a small number of genetic elements, and that these elements are also found in non-myelin proteins. Furthermore, the proteolipid appears to have evolved by acquisition of elements from a ‘gene pool’ over a period of time, rather than by a simple duplication mechanism

Band offsets in Si/Si1–x–yGexCy heterojunctions measured by admittance spectroscopy

We have used admittance spectroscopy to measure conduction-band and valence-band offsets in Si/Si1–xGex and Si/Si1–x–yGexCy heterostructures grown by solid-source molecular-beam epitaxy. Valence-band offsets measured for Si/Si1–xGex heterojunctions were in excellent agreement with previously reported values. Incorporation of C into Si1–x–yGexCy lowers the valence- and conduction-band-edge energies compared to those in Si1–xGex with the same Ge concentration. Comparison of our measured band offsets with previously reported measurements of energy band gaps in Si1–x–yGexCy and Si1–yCy alloy layers indicate that the band alignment is Type I for the compositions we have studied and that our measured band offsets are in quantitative agreement with these previously reported results

Electronic properties of Si/Si1–x–yGexCy heterojunctions

We have used admittance spectroscopy and deep-level transient spectroscopy to characterize electronic properties of Si/Si1–x–yGexCy heterostructures. Band offsets measured by admittance spectroscopy for compressively strained Si/Si1–x–yGexCy heterojunctions indicate that incorporation of C into Si1–x–yGexCy lowers both the valence- and conduction-band edges compared to those in Si1–xGex by an average of 107 ± 6 meV/% C and 75 ± 6 meV/% C, respectively. Combining these measurements indicates that the band alignment is type I for the compositions we have studied, and that these results are consistent with previously reported results on the energy band gap of Si1–x–yGexCy and with measurements of conduction band offsets in Si/Si1–yCy heterojunctions. Several electron traps were observed using deep-level transient spectroscopy on two n-type heterostructures. Despite the presence of a significant amount of nonsubstitutional C (0.29–1.6 at. %), none of the peaks appear attributable to previously reported interstitial C levels. Possible sources for these levels are discussed

Measurement of band offsets in Si/Si1–xGex and Si/Si1–x–yGexCy heterojunctions

Realization of group IV heterostructure devices requires the accurate measurement of the energy band offsets in Si/Si1–xGex and Si/Si1–x–yGexCy heterojunctions. Using admittance spectroscopy, we have measured valence-band offsets in Si/Si1–xGex heterostructures and conduction-band and valence-band offsets in Si/Si1–x–yGexCy heterostructures grown by solid-source molecular-beam epitaxy. Measured Si/Si1–xGex valence-band offsets were in excellent agreement with previously reported values. For Si/Si1–x–yGexCy our measurements yielded a conduction-band offset of 100 ± 11 meV for a n-type Si/Si0.82Ge0.169C0.011 heterojunction and valence-band offsets of 118 ± 12 meV for a p-type Si/Si0.79Ge0.206C0.004 heterojunction and 223 ± 20 meV for a p-type Si/Si0.595Ge0.394C0.011 heterojunction. Comparison of our measured band offsets with previously reported measurements of energy band gaps in Si1–x–yGexCy and Si1–yCy alloy layers indicates that the band alignment is type I for the compositions we have studied and that our measured band offsets are in quantitative agreement with these previously reported results

Deep-level transient spectroscopy of Si/Si1–x–yGexCy heterostructures

Deep-level transient spectroscopy was used to measure the activation energies of deep levels in n-type Si/Si1–x–yGexCy heterostructures grown by solid-source molecular-beam epitaxy. Four deep levels have been observed at various activation energies ranging from 231 to 405 meV below the conduction band. The largest deep-level concentration observed was in the deepest level and was found to be approximately 2 × 10^15 cm^–3. Although a large amount of nonsubstitutional C was present in the alloy layers (1–2 at. %), no deep levels were observed at any energy levels that, to the best of our knowledge, have been previously attributed to interstitial C

On Dirac sheet configurations of SU(2) lattice fields

Finite temperature Euclidean SU(2) lattice gauge fields close to the deconfinement phase transition are subjected to cooling. We find relatively stable or absolutely stable configurations with an action below the one-instanton action $S_{inst}=2\pi^2$ both in the deconfinement and the confinement phases. In this paper we attempt an interpretation of these lowest action configurations. Their action is purely magnetic and amounts to $S/S_{inst} \approx N_t/N_s$, where $N_t$ ($N_s$) is the timelike (spacelike) lattice size, while the topological charge vanishes. In the confined phase part of the corresponding lattice configurations turns out to be absolutely stable with respect to the cooling process in which case Abelian projection reveals a homogeneous, purely Abelian magnetic field closed over the "boundary" in one of the spatial directions. Referring to the dyonic structure established for the confinement phase near $T_c$ and based on the observation made for this phase that such events below the instanton action $S_{inst}$ emerge from dyon-antidyon annihilation, the question of stability (metastability) is discussed for both phases. The hypothetically different dyonic structure of the deconfinement phase, inaccessible by cooling, could explain the metastability.Comment: 14 pages, 7 figure

Probing Patchy Reionization with the Void Probability Function of Lyman-α\alpha Emitters

We probe what constraints for the global ionized hydrogen fraction the Void Probability Function (VPF) clustering can give for the Lyman-Alpha Galaxies in the Epoch of Reionization (LAGER) narrowband survey as a function of area. Neutral hydrogen acts like a fog for Lyman-alpha emission, and measuring the drop in the luminosity function of Lyman-$\alpha$ emitters (LAEs) has been used to constrain the ionization fraction in narrowband surveys. However, the clustering of LAEs is independent from the luminosity function's inherent evolution, and can offer additional constraints for reionization under different models. The VPF measures how likely a given circle is to be empty. It is a volume-averaged clustering statistic that traces the behavior of higher order correlations, and its simplicity offers helpful frameworks for planning surveys. Using the \citet{Jensen2014} simulations of LAEs within various amount of ionized intergalactic medium, we predict the behavior of the VPF in one (301x150.5x30 Mpc$^3$), four (5.44$\times 10^6$ Mpc$^3$), or eight (1.1$\times 10^7$ Mpc$^3$) fields of LAGER imaging. We examine the VPF at 5 and 13 arcminutes, corresponding to the minimum scale implied by the LAE density and the separation of the 2D VPF from random, and the maximum scale from the 8-field 15.5 deg$^2$ LAGER area. We find that even a single DECam field of LAGER (2-3 deg$^2$) could discriminate between mostly neutral vs. ionized. Additionally, we find four fields allows the distinction between 30, 50, and 95 percent ionized; and that eight fields could even distinguish between 30, 50, 73, and 95 percent ionized.Comment: 14 pages, 5 figure

Point-of-care ultrasound induced changes in management of unselected patients in the emergency department - a prospective single-blinded observational trial

Background Point-of-Care ultrasound (POCUS) changes the management in specific groups of patients in the Emergency Department (ED). It seems intuitive that POCUS holds an unexploited potential on a wide variety of patients. However, little is known about the effect of ultrasound on the broad spectrum of unselected patients in the ED. This study aimed to identify the effect on the clinical management if POCUS was applied on unselected patients. Secondarily the study aimed to identify predictors of ultrasound changing management. Methods This study was a blinded observational single center trial. A basic whole body POCUS protocol was performed in extension to the physical examination. The blinded treating physicians were interviewed about the presumptive diagnosis and plan for the patient. Subsequently the physicians were unblinded to the POCUS results and asked to choose between five options regarding the benefit from POCUS results. Results A total of 403 patients were enrolled in this study. The treating physicians regarded POCUS examinations influence on the diagnostic workup or treatment as following: 1) No new information: 249 (61.8%), 2) No further action: 45 (11.2%), 3) Further diagnostic workup needed: 52 (12.9%), 4) Presumptive diagnosis confirmed 38 (9.4%), and 5) Immediate treatment needed: 19 (4.7%). Predictors of beneficial ultrasound were: (a) triage > 1, (b) patient comorbidities (cardiac disease, hypertension or lung disease), or (c) patients presenting with abdominal pain, dyspnea, or syncope. Conclusion POCUS was found to be potentially beneficial in 27.0% of all patients. High triage score, known cardiac disease, hypertension, pulmonary diseases, a clinical presentation with abdominal pain, dyspnea, or syncope are predictors of this. Future research should focus on patient-important outcomes when applying POCUS on these patients. Trial registration The trail was registered prior to patient inclusion with the Danish Data Protection Agency (https://www.datatilsynet.dk/ Case no: 1–16–02-603-14) and Clinical Trials (www.clinicaltrials.gov/ Protocol ID: DNVK1305018)

Systematic trends in beta-delayed particle emitting nuclei: The case of beta-p-alpha emission from 21Mg

We have observed beta+-delayed alpha and p-alpha emission from the proton-rich nucleus 21Mg produced at the ISOLDE facility at CERN. The assignments were cross-checked with a time distribution analysis. This is the third identified case of beta-p-alpha emission. We discuss the systematic of beta-delayed particle emission decays, show that our observed decays fit naturally into the existing pattern, and argue that the patterns are to a large extent caused by odd-even effects.Comment: 6 pages, 5 figure