gem-Dibromocyclopropanes and enzymatically derived cis-1,2-dihydrocatechols as building blocks in alkaloid synthesis

The application of the title building blocks, the 6,6-dibromobicyclo[3.1.0]hexanes and the cis-1,2-dihydrocatechols, to the total synthesis of crinine and lycorinine alkaloids is described.We thank the Australian Research Council and the Institute of Advanced Studies for generous financial support

Discovery of a Radio-loud/Radio-quiet Binary Quasar

We report the discovery of a small separation quasar pair (z=0.586, O=18.4, 19.2, sep. = 2.3 arcsec) associated with the radio source FIRST J164311.3+315618 (S_1400 = 120 mJy). The spectrum of the brighter quasar (A) has a much stronger narrow emission-line spectrum than the other (B), and also stronger Balmer lines relative to the continuum. The continuum ratio of the spectra is flat in the blue at about 2.1, but falls to 1.5 at longer wavelengths. A K' image shows two unresolved sources with a flux ratio of 1.3. The different colors appear to result from the contribution of the host galaxy of B, which is evident from Ca II and high-order Balmer absorption lines indicative of a substantial young stellar population. New 3.6 cm VLA observations show that the compact radio source is coincident with quasar A (B is only marginally detected). We rule out the lensing hypothesis because the optical flux ratio is A/B = 1.2 to 2, while the radio flux ratio is A/B > 40, and conclude that this system is a binary. Moreover, the radio-loud quasar is a compact steep spectrum source. FIRST J164311.3+315618A, B is the lowest redshift and smallest separation binary quasar yet identified.Comment: 8 pages, 3 figures, to appear in Astrophysical Journal Letter

Experimental evidence of spontaneous symmetry breaking in intracavity type-II second harmonic generation with triple resonance

We describe an experiment showing a spontaneous symmetry breaking phenomenon between the intensities of the ordinary and extraordinary components of the fundamental field in intracavity type-II harmonic generation. It is based on a triply resonant dual cavity containing a type II phase matched $\chi^{(2)}$ crystal pumped at the fundamental frequency $\omega_0$. The pump beam generates in the cavity a second harmonic mode at frequency $2\omega_0$ which acts as a pump for frequency degenerate type II parametric down conversion. Under operating conditions which are precisely symmetric with respect to the ordinary and extraordinary components of the fundamental wave, we have observed a breaking of the symmetry on the intensities of these two waves in agreement with the theoretical predictions.Comment: submitte

The X-ray spectral evolution of Cyg X-2 in the framework of bulk Comptonization

We used the newly developed thermal plus bulk Comptonization model comptb to investigate the spectral evolution of the neutron star LMXB Cyg X-2 along its Z-track. We selected a single source in order to trace in a quantitative way the evolution of the physical parameters of the model. We analyzed archival broad-band BeppoSAX spectra of Cyg X-2. Five broad-band spectra have been newly extracted according to the source position in the Z-track described in the colour-colour and colour-intensity diagrams. We have fitted the spectra of the source with two comptb components. The first one, with bulk parameter delta=0, dominates the overall source broad-band spectrum and its origin is related to thermal upscattering (Comptonization) of cold seed photons off warm electrons in high-opacity enviroment. We attribute the origin of these seed photons to the part of the disk which illuminates the outer coronal region (transition layer) located between the accretion disk itself and the neutron star surface. This thermal component is roughly constant with time and with inferred mass accretion rate. The second comptb model describes the overall Comptonization (thermal plus bulk, delta > 0) of hotter seed photons which come from both the inner transition layer and from the neutron star surface. The appearance of this component in the colour-colour or hardness-intensity diagram is more pronounced in the horizontal branch and is progressively disappearing towards the normal branch, where a pure blackbody spectrum is observed. The spectral evolution of Cyg X-2 is studied and interpreted in terms of changes in the innermost environmental conditions of the system, leading to a variable thermal-bulk Comptonization efficiency.Comment: 10 pages, 7 figures, accepted for publication in A&

Supersymmetric renormalization prescription in N = 4 super-Yang--Mills theory

Using the shadow dependent decoupled Slavnov-Taylor identities associated to gauge invariance and supersymmetry, we discuss the renormalization of the N=4 super-Yang-Mills theory and of its coupling to gauge-invariant operators. We specify the method for the determination of non-supersymmetric counterterms that are needed to maintain supersymmetry

Fine-Scale Dissection of Functional Protein Network Organization by Statistical Network Analysis

Revealing organizational principles of biological networks is an important goal of systems biology. In this study, we sought to analyze the dynamic organizational principles within the protein interaction network by studying the characteristics of individual neighborhoods of proteins within the network based on their gene expression as well as protein-protein interaction patterns. By clustering proteins into distinct groups based on their neighborhood gene expression characteristics, we identify several significant trends in the dynamic organization of the protein interaction network. We show that proteins with distinct neighborhood gene expression characteristics are positioned in specific localities in the protein interaction network thereby playing specific roles in the dynamic network connectivity. Remarkably, our analysis reveals a neighborhood characteristic that corresponds to the most centrally located group of proteins within the network. Further, we show that the connectivity pattern displayed by this group is consistent with the notion of “rich club connectivity” in complex networks. Importantly, our findings are largely reproducible in networks constructed using independent and different datasets

Discovery of a Classic FR-II Broad Absorption Line Quasar from the FIRST Survey

We have discovered a remarkable quasar, FIRST J101614.3+520916, whose optical spectrum shows unambiguous broad absorption features while its double-lobed radio morphology and luminosity clearly indicate a classic Fanaroff-Riley Type II radio source. Its radio luminosity places it at the extreme of the recently established class of radio-loud broad absorption line quasars (Becker et al. 1997, 2000; Brotherton et al. 1998). Because of its hybrid nature, we speculate that FIRST J101614.3+520916 is a typical FR-II quasar which has been rejuvenated as a broad absorption line (BAL) quasar with a Compact Steep Spectrum core. The direction of the jet axis of FIRST J101614.3+520916 can be estimated from its radio structure and optical brightness, indicating that we are viewing the system at a viewing angle of > 40 degrees. The position angles of the radio jet and optical polarization are not well-aligned, differing by 20 to 30 degrees. When combined with the evidence presented by Becker et al. (2000) for a sample of 29 BAL quasars showing that at least some BAL quasars are viewed along the jet axis, the implication is that no preferred viewing orientation is necessary to observe BAL systems in a quasar's spectrum. This, and the probable young nature of compact steep spectrum sources, leads naturally to the alternate hypothesis that BALs are an early stage in the lives of quasars.Comment: 14 pages, 6 postscript figures; accepted for publication in the Astrophysical Journa

What Determines the Depth of BALs? Keck HIRES Observations of BALQSO 1603+300

We find that the depth and shape of the broad absorption lines (BALs) in BALQSO 1603+3002 are determined largely by the fraction of the emitting source which is covered by the BAL flow. In addition, the observed depth of the BALs is poorly correlated with their real optical depth. The implication of this result is that abundance studies based on direct extraction of column densities from the depth of the absorption troughs are unreliable. Our conclusion is based on analysis of unblended absorption features of two lines from the same ion (in this case the Si IV doublet), which allows unambiguous separation of covering factor and optical depth effects. The complex morphology of the covering factor as a function of velocity suggests that the BALs are produced by several physically separated outflows. The covering factor is ion dependent in both depth and velocity width. We also find evidence that in BALQSO 1603+3002 the flow does not cover the broad emission line region.Comment: 13 pages, 2 figures, accepted for publication in Ap

Flux density measurements of a complete sample of faint blazars

We performed observations with the Effelsberg 100-m radio telescope to measure flux densities and polarised emission of sources selected from the "Deep X-ray Radio Blazar Survey" (DXRBS) to better define their spectral index behaviour in the radio band, with the aim to construct a homogeneous sample of blazars. Sources were observed at four different frequencies with the Effelsberg 100-m telescope. We complemented these measurements with flux density data at 1.4GHz derived from the NRAO VLA Sky Survey.The spectral indices of a sample of faint blazars were computed making use of almost simultaneous measurements. Sixty-six percent of the sources can be classified as "bona fide" blazars. Seven objects show a clearly inverted spectral index. Seventeen sources previously classified as flat spectrum radio quasars (FSRQs) are actually steep spectrum radio quasars (SSRQs). The flux densities obtained with the Effelsberg 100-m telescope at 5GHz are compared with the flux densities listed in the Green Bank GB6 survey and in the Parkes-MIT-NRAO PMN catalogue. About 43% of the sources in our sample exhibit flux density variations on temporal scales of 19 or 22 years. We confirm that 75 out of 103 sources of the DXRBS are indeed FSRQs. Twenty-seven sources show a spectral index steeper than -0.5 and should be classified as SSRQs. Polarised emission was detected for 36 sources at 4.85GHz. The median value of the percentage of polarised emission is (5.8+-0.9$)%. Five sources show rotation measure (RM) values >200 rad m^-2.Comment: Accepted for publication in Astronomy and Astrophysic